Rapid Direct Excitation and Long-Lasting Enhancement of NMDA Response by Group I Metabotropic Glutamate Receptor Activation of Hypothalamic Melanin-Concentrating Hormone Neurons
Huang H, van den Pol AN. Rapid Direct Excitation and Long-Lasting Enhancement of NMDA Response by Group I Metabotropic Glutamate Receptor Activation of Hypothalamic Melanin-Concentrating Hormone Neurons. Journal Of Neuroscience 2007, 27: 11560-11572. PMID: 17959799, PMCID: PMC6673210, DOI: 10.1523/jneurosci.2147-07.2007.Peer-Reviewed Original ResearchConceptsGroup I metabotropic glutamate receptor activationMetabotropic glutamate receptor activationDHPG-induced depolarizationGlutamate receptor activationGroup IHormone neuronsMGluR5 antagonistGreen fluorescent protein-expressing transgenic miceNMDA receptor-mediated postsynaptic currentsReceptor activationExchanger blocker KB-R7943Melanin-concentrating hormone (MCH) neuronsMelanin-Concentrating Hormone NeuronsReceptor-mediated postsynaptic currentsBlockade of mGluR1Selective group IGroup I mGluRsPatch-clamp recordingsMCH neuron activityI mGluRsMCH neuronsHypocretin neuronsSpontaneous EPSCsPostsynaptic mechanismsHypothalamic slices