2014
Methylmercury-Induced Inhibition of Paraoxonase-1 (PON1)—Implications for Cardiovascular Risk
Ginsberg G, Sonawane B, Nath R, Lewandowski P. Methylmercury-Induced Inhibition of Paraoxonase-1 (PON1)—Implications for Cardiovascular Risk. Journal Of Toxicology And Environmental Health Part A 2014, 77: 1004-1023. PMID: 25072822, DOI: 10.1080/15287394.2014.919837.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsAryldialkylphosphataseCarboxylic Ester HydrolasesCardiovascular DiseasesDisease Models, AnimalDose-Response Relationship, DrugFatty Acids, Omega-3FishesFood ContaminationHumansLipid MetabolismMeatMethylmercury CompoundsMiceReactive Oxygen SpeciesRisk AssessmentRisk FactorsConceptsCardiovascular riskParaoxonase 1PON1 activityDoses of MeHgAcute cardiovascular eventsSerum PON1 activityHigh-density lipoproteinCardiovascular eventsBlood lipidsMeHg doseCardiovascular healthFish-eating populationsCardiovascular diseaseCardioprotective factorPON1 levelsVascular endotheliumDisease processEpidemiology studiesClinical biomarkersPopulation riskBiochemical effectsAntioxidant defenseRiskFish consumptionDisease biomarkers
2011
Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans
Chiu WA, Ginsberg GL. Development and evaluation of a harmonized physiologically based pharmacokinetic (PBPK) model for perchloroethylene toxicokinetics in mice, rats, and humans. Toxicology And Applied Pharmacology 2011, 253: 203-234. PMID: 21466818, DOI: 10.1016/j.taap.2011.03.020.Peer-Reviewed Original Research