Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM
Crawford FW, Khayal IS, McGue C, Saraswathy S, Pirzkall A, Cha S, Lamborn KR, Chang SM, Berger MS, Nelson SJ. Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM. Journal Of Neuro-Oncology 2008, 91: 337. PMID: 19009235, PMCID: PMC3022444, DOI: 10.1007/s11060-008-9719-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAspartic AcidBrain MappingBrain NeoplasmsCholineCreatineDiagnosis, DifferentialDiffusion Magnetic Resonance ImagingFemaleGlioblastomaHumansImage EnhancementImage Processing, Computer-AssistedKaplan-Meier EstimateLactic AcidLipidsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedProtonsRadionuclide ImagingRetrospective StudiesConceptsGlioblastoma multiformeApparent diffusion coefficientPoor survivalConventional anatomical MR imagingAnatomical MR imagingUntreated glioblastoma multiformeT2 hyperintense lesionsMedian survival timeLow-risk groupBlood-brain barrierStratification of patientsContrast-enhancing lesionsPerfusion-weighted imagingDiffusion-weighted imagingPhysiological MRProton MR spectroscopicFavorable survivalSurgical resectionT2 lesionsHyperintense lesionsPrognostic valueBrain barrierElevated cholineClinical trialsLesion volumeEvaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy
Saraswathy S, Crawford FW, Lamborn KR, Pirzkall A, Chang S, Cha S, Nelson SJ. Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy. Journal Of Neuro-Oncology 2008, 91: 69-81. PMID: 18810326, PMCID: PMC3022437, DOI: 10.1007/s11060-008-9685-3.Peer-Reviewed Original ResearchConceptsGlioblastoma multiformeRadiation therapyExternal beam radiation therapyLethal primary brain tumorProportional hazards analysisSurvival of patientsPrimary brain tumorsSpecific treatment protocolsBeam radiation therapyAdjuvant radiationAdjuvant therapySurgical resectionLesion burdenMR parametersPoor outcomeAnatomic lesionsPoor survivalScanner field strengthTreatment protocolStudy populationFocal therapyHigh riskBrain tumorsPatientsPredictive value