Randomized controlled trials of biomarker targets
Erlendsdottir M, Crawford F. Randomized controlled trials of biomarker targets. Clinical Trials 2022, 20: 47-58. PMID: 36373783, PMCID: PMC9974557, DOI: 10.1177/17407745221131820.Peer-Reviewed Original ResearchConceptsBlood pressure targetsManagement of hypertensionPressure targetsTreatment strategiesBiomarker targetsControlled TrialsRandomized trialsPatient populationLower blood pressure targetsIntensive blood pressure controlAcute respiratory distress syndromePhysicians attemptNew randomized trialsBlood pressure controlRespiratory distress syndromeLack of blindingTrial patient populationValidity of trialsAdaptive treatment strategiesAntihypertensive medicationsAvailable medicationsDistress syndromeTreat analysisTime-varying confoundingTreatment algorithm