2018
Genome-wide association analysis identifies a meningioma risk locus at 11p15.5
Claus EB, Cornish AJ, Broderick P, Schildkraut JM, Dobbins SE, Holroyd A, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Swerdlow A, Larsen SB, Johansen C, Simon M, Bondy M, Wrensch M, Houlston RS, Wiemels JL. Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. Neuro-Oncology 2018, 20: 1485-1493. PMID: 29762745, PMCID: PMC6176799, DOI: 10.1093/neuonc/noy077.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCase-Control StudiesChromosomes, Human, Pair 11FemaleFollow-Up StudiesGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMaleMeningeal NeoplasmsMeningiomaMiddle AgedPolymorphism, Single NucleotidePrognosisRisk FactorsYoung AdultConceptsGenome-wide association studiesRisk lociGenome-wide association analysisSusceptibility lociNeural crest-derived structuresSignificant heritable basisNumber of genesIndependent sample seriesNew susceptibility lociHeritable basisGenetic basisGenome ProjectAssociation studiesAssociation analysisLinkage disequilibriumLociMeningioma developmentReference panelPolygenic modelCentral roleUK10K dataAdult brain tumorsRIC8AMeningeal coveringsGenes
2017
Quality of life after surgery for intracranial meningioma
Benz LS, Wrensch MR, Schildkraut JM, Bondy ML, Warren JL, Wiemels JL, Claus EB. Quality of life after surgery for intracranial meningioma. Cancer 2017, 124: 161-166. PMID: 28902404, PMCID: PMC6415762, DOI: 10.1002/cncr.30975.Peer-Reviewed Original ResearchConceptsMedical Outcomes Study Short Form-36 Health SurveyShort Form-36 Health SurveyGeneral healthy populationCase-control studyLong-term qualityCase/control statusResidents of ConnecticutDomains of PhysicalRole PhysicalRole EmotionalInitial diagnosisQOL outcomesHealthy controlsClinical significanceHealth SurveyMeningioma casesIntracranial meningiomasCurrent studyHealthy populationControl statusTelephone interviewsPatientsMental healthMeningiomasSignificant decrease
2015
The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium
Amirian ES, Armstrong GN, Zhou R, Lau CC, Claus EB, Barnholtz-Sloan JS, Il'yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, Johansen C, Houlston RS, Jenkins RB, Lachance D, Olson SH, Bernstein JL, Merrell RT, Wrensch MR, Davis FG, Lai R, Shete S, Amos CI, Scheurer ME, Aldape K, Alafuzoff I, Brännström T, Broholm H, Collins P, Giannini C, Rosenblum M, Tihan T, Melin BS, Bondy ML. The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium. American Journal Of Epidemiology 2015, 183: 85-91. PMID: 26656478, PMCID: PMC4706682, DOI: 10.1093/aje/kwv235.Peer-Reviewed Original ResearchConceptsInternational case-control studyCase-control studyGlioma studiesGlioma International Case-Control StudyFatal brain cancerGenetic epidemiologyEtiological factorsBlood samplesGene-environment interactionsRetrospective exposure assessmentTumor subtypesBrain cancerMultiple data collection sitesSmall sample sizeBiospecimen collectionExposure assessmentInternational ConsortiumEpidemiologyCommon protocolSample sizeData collection sitesClinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma
Ramkissoon SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S, Knoff D, Dubuc A, Brown L, Burns M, Cryan JB, Abedalthagafi M, Kang YJ, Schultz N, Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L, Ruland S, Doherty LM, LaFrankie DC, Horvath M, Aizer AA, Russo A, Arvold ND, Claus EB, Al-Mefty O, Johnson MD, Golby AJ, Dunn IF, Chiocca EA, Trippa L, Santagata S, Folkerth RD, Kantoff P, Rollins BJ, Lindeman NI, Wen PY, Ligon AH, Beroukhim R, Alexander BM, Ligon KL. Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro-Oncology 2015, 17: 1344-1355. PMID: 25754088, PMCID: PMC4578577, DOI: 10.1093/neuonc/nov015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBrain NeoplasmsChildChild, PreschoolComparative Genomic HybridizationDNA Copy Number VariationsFemaleGene Expression ProfilingGenome-Wide Association StudyGenotypeGlioblastomaHumansInfantIsocitrate DehydrogenaseMaleMiddle AgedMutationProspective StudiesPTEN PhosphohydrolaseTumor Suppressor Protein p53Young AdultConceptsClinical trialsBrain tumorsGlioblastoma patientsClinical settingClinical Laboratory Improvement AmendmentsParaffin-embedded samplesWhole-genome array comparative genomic hybridizationWhole gene sequencingTherapeutic trialsWhole-genome copy numberClinical testing resultsPatientsClinical diagnosisMutation profilingIntegral biomarkerArray comparative genomic hybridizationGlioblastomaClinical implementationTrialsComparative genomic hybridizationTumor suppressor inactivationCopy numberTumorsFFPE samplesDiagnostic laboratoriesSurvival and low-grade glioma: the emergence of genetic information.
Claus EB, Walsh KM, Wiencke JK, Molinaro AM, Wiemels JL, Schildkraut JM, Bondy ML, Berger M, Jenkins R, Wrensch M. Survival and low-grade glioma: the emergence of genetic information. Neurosurgical FOCUS 2015, 38: e6. PMID: 25552286, PMCID: PMC4361022, DOI: 10.3171/2014.10.focus12367.Peer-Reviewed Original ResearchConceptsLow-grade gliomasHigh-grade gliomasLGG patientsRefining risk stratificationEnd Results ProgramUniformly fatal diseaseRole of tumorNational Cancer InstituteOverall survivalYounger patientsRisk stratificationClinical variablesResults ProgramClinical managementClinical trialsSuch tumorsCurrent treatmentSurvival trendsTumor markersBetter survivalCancer InstitutePatientsFatal diseaseGliomasTumor expression profiles
2012
Dental x‐rays and risk of meningioma
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Dental x‐rays and risk of meningioma. Cancer 2012, 118: 4530-4537. PMID: 22492363, PMCID: PMC3396782, DOI: 10.1002/cncr.26625.Peer-Reviewed Original ResearchConceptsRisk of meningiomaDental X-raysModifiable risk factorsIntracranial meningiomasRisk factorsAge 20Population-based case-control studyMain outcome measuresPrimary brain tumorsCase-control studyGreater frequencyPanorex filmsTumor locationBitewing examinationOutcome measuresElevated riskBrain tumorsControl groupMeningiomasYounger ageRadiation exposureAge 10AgePatientsRisk
2011
Genome-Wide High-Density SNP Linkage Search for Glioma Susceptibility Loci: Results from the Gliogene Consortium
Shete S, Lau CC, Houlston RS, Claus EB, Barnholtz-Sloan J, Lai R, Il'yasova D, Schildkraut J, Sadetzki S, Johansen C, Bernstein JL, Olson SH, Jenkins RB, Yang P, Vick NA, Wrensch M, Davis FG, McCarthy BJ, Leung EH, Davis C, Cheng R, Hosking FJ, Armstrong GN, Liu Y, Yu RK, Henriksson R, Consortium T, Melin BS, Bondy ML. Genome-Wide High-Density SNP Linkage Search for Glioma Susceptibility Loci: Results from the Gliogene Consortium. Cancer Research 2011, 71: 7568-7575. PMID: 22037877, PMCID: PMC3242820, DOI: 10.1158/0008-5472.can-11-0013.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedBrain NeoplasmsChildChromosome MappingFamily HealthFemaleGenetic HeterogeneityGenetic Predisposition to DiseaseGenome, HumanGenome-Wide Association StudyGenotypeGliomaHumansLinkage DisequilibriumLod ScoreMaleMiddle AgedPedigreePolymorphism, Single NucleotideUnited StatesYoung AdultFamily and personal medical history and risk of meningioma.
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Family and personal medical history and risk of meningioma. Journal Of Neurosurgery 2011, 115: 1072-7. PMID: 21780859, PMCID: PMC3241000, DOI: 10.3171/2011.6.jns11129.Peer-Reviewed Original ResearchConceptsFirst-degree family historyPersonal medical historyMedical historyFamily historyMeningioma riskEpidemiology of meningiomaPrimary brain tumorsCase-control studyRisk of meningiomaUterine fibroid tumorsImmune conditionsThyroid cancerYoungest caseBreast cancerRole of hormonesBrain tumorsFibroid tumorsImmune systemControl individualsPatientsMeningiomasInfluence of geneticsStrong associationFurther studiesTumors