2023
Mediation analysis in the presence of continuous exposure measurement error
Cheng C, Spiegelman D, Li F. Mediation analysis in the presence of continuous exposure measurement error. Statistics In Medicine 2023, 42: 1669-1686. PMID: 36869626, PMCID: PMC11320713, DOI: 10.1002/sim.9693.Peer-Reviewed Original ResearchConceptsBody mass indexExposure measurement errorPhysical activityMediation proportionHealth Professionals FollowCardiovascular disease incidenceProfessionals FollowMediation analysisMass indexCardiovascular diseaseLower riskStudy designEffect estimatesValidation study designContinuous exposureBiased effect estimatesTrue exposureMediatorsExposureValidation studyBinary outcomesHealth science studiesOutcomesRiskDisease incidence
2022
Long-Term Survival and Causes of Death After Diagnoses of Common Cancers in 3 Cohorts of U.S. Health Professionals
Cheng E, Lee DH, Tamimi RM, Hankinson SE, Willett WC, Giovannucci EL, Eliassen AH, Stampfer MJ, Mucci LA, Fuchs CS, Spiegelman D. Long-Term Survival and Causes of Death After Diagnoses of Common Cancers in 3 Cohorts of U.S. Health Professionals. JNCI Cancer Spectrum 2022, 6: pkac021-. PMID: 35603853, PMCID: PMC8973409, DOI: 10.1093/jncics/pkac021.Peer-Reviewed Original ResearchConceptsCancer-specific mortalityHealth Study IIUterine corpusCause of deathCommon cancerThyroid cancerPrimary cancerCancer survivorsLung cancerCumulative mortalityHealth StudyColorectal cancer-specific mortalityLong-term overall survivalNurses' Health Study IICancer-specific mortality ratesU.S. health professionalsHealth Professionals FollowNurses' Health StudyMale cancer survivorsFemale cancer survivorsProfessionals FollowMost patientsOverall survivalExcess riskUrinary bladder
2020
Long-term cancer survival in cohorts of U.S. health professionals.
Cheng E, Lee D, Tamimi R, Hankinson S, Willett W, Giovannucci E, Eliassen H, Tworoger S, Meir S, Mucci L, Fuchs C, Spiegelman D. Long-term cancer survival in cohorts of U.S. health professionals. Journal Of Clinical Oncology 2020, 38: 12075-12075. DOI: 10.1200/jco.2020.38.15_suppl.12075.Peer-Reviewed Original ResearchCancer-specific mortality ratesMortality rateCancer patientsOvarian cancerMajor cancersLong-term cancer survivalCorpus cancer patientsU.S. health professionalsHealth Professionals FollowUterine corpus cancerKaplan-Meier curvesMortality 10 yearsCause-specific mortality ratesCause of deathCumulative mortality rateLong-term survivalNHS IICorpus cancerIndex cancerProfessionals FollowUterine corpusColorectal cancerCancer survivalBreast cancerHealth Study
2018
The effect of risk factor misclassification on the partial population attributable risk
Wong BHW, Peskoe SB, Spiegelman D. The effect of risk factor misclassification on the partial population attributable risk. Statistics In Medicine 2018, 37: 1259-1275. PMID: 29333614, PMCID: PMC6003717, DOI: 10.1002/sim.7559.Peer-Reviewed Original ResearchConceptsPartial population attributable riskPopulation attributable riskRisk factorsAttributable riskRelative riskMultivariate-adjusted relative riskRed meatHealth Professionals FollowModifiable risk factorsLow folate intakeExposure of interestBackground risk factorsProfessionals FollowAlcohol intakeColorectal cancerFolate intakePublic health researchMultifactorial diseasePreventive interventionsPopulation-level impactJoint prevalenceHealth researchRiskIntakeExposure
2004
Changes in Body Weight and Body Fat Distribution as Risk Factors for Clinical Diabetes in US Men
Koh-Banerjee P, Wang Y, Hu FB, Spiegelman D, Willett WC, Rimm EB. Changes in Body Weight and Body Fat Distribution as Risk Factors for Clinical Diabetes in US Men. American Journal Of Epidemiology 2004, 159: 1150-1159. PMID: 15191932, DOI: 10.1093/aje/kwh167.Peer-Reviewed Original ResearchConceptsRisk of diabetesBody fat distributionFat distributionWeight gainBody weightHealth Professionals FollowCases of diabetesWaist gainClinical diabetesProfessionals FollowWaist circumferenceHip circumferenceRisk factorsSubsequent riskUS menDiabetesAbdominal fatWeight changeHip girthMenRiskCircumferenceWaistPercentPrevious studies
2002
Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin
Fung TT, Spiegelman D, Egan KM, Giovannucci E, Hunter DJ, Willett WC. Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin. International Journal Of Cancer 2002, 103: 110-115. PMID: 12455062, DOI: 10.1002/ijc.10798.Peer-Reviewed Original ResearchConceptsCases of SCCHEALTHY studyProspective cohort study designMale health professionalsHealth Professionals FollowCohort study designIntake of vitaminsSquamous cell carcinomaSignificant inverse associationDevelopment of SCCImportant protective roleIncidence of SCCBiennial questionnairesProfessionals FollowMultivariate adjustmentCell carcinomaSCC incidenceDietary factorsInverse associationMedical recordsRisk factorsRelative riskLarge cohortCarotenoid intakeSun exposure
2001
Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria
Willett W, Stampfer M, Chu NF, Spiegelman D, Holmes M, Rimm E. Assessment of Questionnaire Validity for Measuring Total Fat Intake using Plasma Lipid Levels as Criteria. American Journal Of Epidemiology 2001, 154: 1107-1112. PMID: 11744515, DOI: 10.1093/aje/154.12.1107.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkersBody Mass IndexBody WeightCholesterol, HDLCohort StudiesCross-Sectional StudiesDiet SurveysDietary FatsDietary FiberDietary ProteinsEnergy IntakeExerciseFastingFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesRegression AnalysisReproducibility of ResultsSmokingSurveys and QuestionnairesTriglyceridesConceptsTotal fat intakeFood frequency questionnaireFat intakeTriglyceride levelsFrequency questionnaireDietary fatSemiquantitative food frequency questionnaireHealth Professionals FollowBody mass indexHigh fat intakePlasma lipid levelsMetabolic studiesIntake of proteinCross-sectional analysisProfessionals FollowOverweight menMass indexInverse associationLipid levelsPhysical activityBlood specimensAlcohol consumptionSpecific biomarkersIntakeMultiple regression analysisPlasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men
Chu N, Spiegelman D, Hotamisligil G, Rifai N, Stampfer M, Rimm E. Plasma insulin, leptin, and soluble TNF receptors levels in relation to obesity-related atherogenic and thrombogenic cardiovascular disease risk factors among men. Atherosclerosis 2001, 157: 495-503. PMID: 11472752, DOI: 10.1016/s0021-9150(00)00755-3.Peer-Reviewed Original ResearchConceptsCVD risk factorsRisk factorsPlasma insulinCVD riskHDL cholesterolInsulin levelsPlasma leptinAntigen levelsSoluble TNF receptor levelsCardiovascular disease risk factorsTissue plasminogen activator antigen levelsT-PA antigen levelsMetabolic cardiovascular syndromeHealth Professionals FollowIndependent risk factorDisease risk factorsEffect of obesitySoluble TNF receptorsTNF receptor levelsCardiovascular disease morbidityBody mass indexLevels of insulinProfessionals FollowLeptin levelsMass indexProspective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3
Cho E, Hung S, Willett W, Spiegelman D, Rimm E, Seddon J, Colditz G, Hankinson S. Prospective study of dietary fat and the risk of age-related macular degeneration 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 73: 209-218. PMID: 11157315, DOI: 10.1093/ajcn/73.2.209.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationRisk of AMDTotal fat intakeFat intakeRelative riskHealth StudyPooled multivariate relative risksDiagnosis of AMDFish/wkModest inverse relationServings/moHealth Professionals FollowMultivariate relative riskNurses' Health StudyFood frequency questionnaireProfessionals FollowStudy of participantsProspective followVisual lossProspective studyLowest quintileDietary fatMacular degenerationHigh intakeLinolenic acidAssociation between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk 1 , 2 , 3
Fung T, Rimm E, Spiegelman D, Rifai N, Tofler G, Willett W, Hu F. Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 73: 61-67. PMID: 11124751, DOI: 10.1093/ajcn/73.1.61.Peer-Reviewed Original ResearchConceptsMajor dietary patternsFood frequency questionnaireBiomarkers of obesityDietary patternsHomocysteine concentrationsHigh intakePattern scoresHigh-fat dairy productsHealth Professionals FollowOverall dietary patternsCardiovascular disease riskBody mass indexPlasma folate concentrationsPrudent patternProfessionals FollowCVD riskDevelopment of diseaseSmoking statusAlcohol intakeMass indexPotential confoundersObesity riskPlasma biomarkersPlasma folateRisk factors
2000
Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men
Chu N, Spiegelman D, Rifai N, Hotamisligil G, Rimm E. Glycemic status and soluble tumor necrosis factor receptor levels in relation to plasma leptin concentrations among normal weight and overweight US men. International Journal Of Obesity 2000, 24: 1085-1092. PMID: 11033975, DOI: 10.1038/sj.ijo.0801361.Peer-Reviewed Original ResearchConceptsPlasma leptinSTNF-R1C-peptideOverweight menGlycemic statusLeptin concentrationsGlucose homeostasisSoluble tumor necrosis factor receptor levelsSoluble tumour necrosis factor receptor concentrationsTumor necrosis factor receptor levelsDetailed lifestyle questionnaireSTNF-R2 concentrationsHealth Professionals FollowBody mass indexPlasma leptin levelsObesity-related disordersAdipose-derived cytokineCross-sectional studyConsiderable inter-individual variationProfessionals FollowDiabetes mellitusLeptin levelsMass indexNormal weightHighest quintileProportion of colon cancer risk that might be preventable in a cohort of middle-aged US men
Platz E, Willett W, Colditz G, Rimm E, Spiegelman D, Giovannucci E. Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men. Cancer Causes & Control 2000, 11: 579-588. PMID: 10977102, DOI: 10.1023/a:1008999232442.Peer-Reviewed Original ResearchConceptsColon cancer riskMiddle-aged US menRisk factorsCancer riskRisk scoreUS menPopulation attributable risk percentColon cancer risk factorsHealth Professionals FollowModifiable risk factorsAttributable risk percentCancer risk factorsColon cancer incidenceLow-risk scoresRed meat consumptionColon cancer casesLogistic regression modelsProfessionals FollowCigarette smokingColorectal neoplasiaColorectal cancerPhysical inactivityCancer incidenceCancer casesFamily history
1999
Risk Factors for Basal Cell Carcinoma of the Skin in Men: Results from the Health Professionals Follow-up Study
van Dam R, Huang Z, Rimm E, Weinstock M, Spiegelman D, Colditz G, Wiflett W, Giovannucci E. Risk Factors for Basal Cell Carcinoma of the Skin in Men: Results from the Health Professionals Follow-up Study. American Journal Of Epidemiology 1999, 150: 459-468. PMID: 10472945, DOI: 10.1093/oxfordjournals.aje.a010034.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaBCC riskCell carcinomaSun exposureElevated riskUS male health professionalsMale health professionalsHealth Professionals FollowConstitutional factorsRisk of BCCYears of ageRegion of residenceBlistering sunburnsProfessionals FollowProspective cohortRisk factorsNorth European ancestryHealth professionalsLifetime numberCarcinomaRiskMenRed hairEuropean ancestrySkinA Prospective Study of Egg Consumption and Risk of Cardiovascular Disease in Men and Women
Hu FB, Stampfer MJ, Rimm EB, Manson JE, Ascherio A, Colditz GA, Rosner BA, Spiegelman D, Speizer FE, Sacks FM, Hennekens CH, Willett WC. A Prospective Study of Egg Consumption and Risk of Cardiovascular Disease in Men and Women. JAMA 1999, 281: 1387-1394. PMID: 10217054, DOI: 10.1001/jama.281.15.1387.Peer-Reviewed Original ResearchConceptsRisk of CHDCoronary heart diseaseHigher egg consumptionIncident casesEgg consumptionRelative riskCardiovascular diseaseHealth StudyFatal coronary heart diseaseStudy outsetIncident nonfatal myocardial infarctionCHD risk factorsHealth Professionals FollowNonfatal myocardial infarctionNurses' Health StudyProspective cohort studyFood frequency questionnaireCategories of intakeBlood cholesterol levelsDaily egg consumptionOverall significant associationProfessionals FollowCohort studyDiabetic subjectsProspective studyFruit and Vegetable Intake and Incidence of Bladder Cancer in a Male Prospective Cohort
Michaud D, Spiegelman D, Clinton S, Rimm E, Willett W, Giovannucci E. Fruit and Vegetable Intake and Incidence of Bladder Cancer in a Male Prospective Cohort. Journal Of The National Cancer Institute 1999, 91: 605-613. PMID: 10203279, DOI: 10.1093/jnci/91.7.605.Peer-Reviewed Original ResearchConceptsBladder cancer riskVegetable intakeCancer riskBladder cancerCruciferous vegetablesIndividual cruciferous vegetablesHealth Professionals FollowTotal fruitProspective cohort studyCruciferous vegetable consumptionFood frequency questionnaireCurrent smoking statusIncident bladder cancerPrevious epidemiologic studiesTotal fluid intakeLogistic regression analysisCarotenoid-rich vegetablesProfessionals FollowCohort studyProspective cohortSmoking statusCigarette smokingGreen leafy vegetablesInverse associationFluid intake
1998
A prospective study of physical activity and prostate cancer in male health professionals.
Giovannucci E, Leitzmann M, Spiegelman D, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. A prospective study of physical activity and prostate cancer in male health professionals. Cancer Research 1998, 58: 5117-22. PMID: 9823321.Peer-Reviewed Original ResearchConceptsMale health professionalsTotal prostate cancerMetastatic prostate cancerProstate cancerPhysical activityMetabolic equivalentsVigorous activityLower riskHealth professionalsLeisure-time physical activityMore metabolic equivalentsNonvigorous physical activityReported average timeHealth Professionals FollowHistory of diabetesProspective cohort studyAdvanced prostate cancerRole of exerciseTime physical activityYears of ageWarrants further studyNonvigorous activitiesMen 40Professionals FollowCohort studyRetrospective Analysis of Birth Weight and Prostate Cancer in the Health Professionals Follow-up Study
Platz E, Giovannucci E, Rimm E, Curhan G, Spiegelman D, Colditz G, Willett W. Retrospective Analysis of Birth Weight and Prostate Cancer in the Health Professionals Follow-up Study. American Journal Of Epidemiology 1998, 147: 1140-1144. PMID: 9645792, DOI: 10.1093/oxfordjournals.aje.a009412.Peer-Reviewed Original ResearchConceptsHealth Professionals FollowBirth weightProstate cancerProfessionals FollowProstate cancer incidenceMultivariate logistic modelModest positive associationGrade tumorsProstatic cancerCancer incidenceRelative riskRetrospective analysisOverall associationCancerPositive associationFollowAssociationLogistic modelWeightTumorsIncidenceThe epidemic of prostate cancer and the medical literature: a causal association?
Giovannucci E, Kantoff P, Spiegelman D, Loughlin K, Wishnow K, Corless C, McDermott A, Willet W, Talcott J. The epidemic of prostate cancer and the medical literature: a causal association? Prostate Cancer And Prostatic Diseases 1998, 1: 148-153. PMID: 12496908, DOI: 10.1038/sj.pcan.4500227.Peer-Reviewed Original ResearchProstate-specific antigenProstate cancerAdvanced tumorsNationwide prospective cohort studyValue of PSANew prostate cancer diagnosesHealth Professionals FollowProspective cohort studyEarly-stage diseaseAge-adjusted incidenceOrgan-confined tumorsOrgan-confined cancerRate of diagnosisProstate cancer diagnosisPoisson regression modelsProfessionals FollowAsymptomatic menCohort studyMetastatic tumorsDisease awarenessNew England JournalSpecific antigenUnprecedented recent increasesCausal associationCancer
1997
Calcium Intake and the Incidence of Forearm and Hip Fractures among Men 1 , 2
Owusu W, Willett W, Feskanich D, Ascherio A, Spiegelman D, Colditz G. Calcium Intake and the Incidence of Forearm and Hip Fractures among Men 1 , 2. Journal Of Nutrition 1997, 127: 1782-1787. PMID: 9278560, DOI: 10.1093/jn/127.9.1782.Peer-Reviewed Original ResearchConceptsIncidence of forearmCalcium intakeBody mass indexHip fractureRelative riskForearm fracturesComparable relative riskHealth Professionals FollowHigh calcium intakeTotal energy intakeRisk of fractureGlass of milkMen 40Professionals FollowModerate traumaMass indexSmoking statusLifestyle factorsHighest quintileLowest quintileEpidemiologic studiesPhysical activityLower riskAlcohol consumptionEnergy intake
1996
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.
Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, Spiegelman D, Willett WC, Hunter DJ. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Research 1996, 56: 4862-4. PMID: 8895734.Peer-Reviewed Original ResearchConceptsVal/Val individualsVal/Val genotypeColorectal cancerOdds ratioVal genotypeHealth Professionals FollowColorectal cancer riskStrong risk factorHigh dietary intakeCase-control studyMore alcoholic drinksMethylenetetrahydrofolate reductase (MTHFR) polymorphismsVariant homozygous genotypeMethylenetetrahydrofolate reductase (MTHFR) geneProfessionals FollowAlcohol intakeInverse associationRisk factorsDietary intakeReduced incidenceMTHFR genotypeCancer riskBlood samplesAlcohol consumptionOncogenic alterations