2024
Bayesian pathway analysis over brain network mediators for survival data
Tian X, Li F, Shen L, Esserman D, Zhao Y. Bayesian pathway analysis over brain network mediators for survival data. Biometrics 2024, 80: ujae132. PMID: 39530270, PMCID: PMC11555425, DOI: 10.1093/biomtc/ujae132.Peer-Reviewed Original ResearchConceptsAccelerated failure time modelFailure time modelBrain connectivityAlzheimer's Disease Neuroimaging Initiative studyMaximum information extractionResponse regressionBayesian approachInformation extractionTime modelSurvival dataNoisy componentsUnique edgeWhite matter fiber tractsNetwork configurationBrain networksInterconnection networksNetworkNetwork mediatorsBrain
2023
Group sequential two‐stage preference designs
Liu R, Li F, Esserman D, Ryan M. Group sequential two‐stage preference designs. Statistics In Medicine 2023, 43: 315-341. PMID: 38010193, DOI: 10.1002/sim.9962.Peer-Reviewed Original ResearchAlcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy
Cartwright E, Pierret C, Minassian C, Esserman D, Tate J, Goetz M, Bhattacharya D, Fiellin D, Justice A, Re V, Rentsch C. Alcohol Use and Sustained Virologic Response to Hepatitis C Virus Direct-Acting Antiviral Therapy. JAMA Network Open 2023, 6: e2335715. PMID: 37751206, PMCID: PMC10523171, DOI: 10.1001/jamanetworkopen.2023.35715.Peer-Reviewed Original ResearchConceptsSustained virologic responseAlcohol use disorderHigh-risk consumptionHistory of AUDLow-risk consumptionDAA therapyAlcohol use categoriesAlcohol useVirologic responseCohort studyAntiviral therapyOdds ratioChronic hepatitis C virus (HCV) infectionAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaireHepatitis C virus infectionVeterans AffairsActing antiviral (DAA) therapyDAA treatment initiationHCV elimination goalsUndetectable HCV RNAC virus infectionFibrosis-4 scoreRetrospective cohort studyMultivariable logistic regressionTenth Revision diagnosisStructural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review.
Pichardo M, Ferrucci L, Molina Y, Esserman D, Irwin M. Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1498-1507. PMID: 37650844, PMCID: PMC10872641, DOI: 10.1158/1055-9965.epi-22-1147.Peer-Reviewed Original ResearchConceptsHispanic/Latino adultsObesity-related cancersLifestyle behaviorsLatino adultsLifestyle guidelinesCancer preventionPoor lifestyle behaviorsU.S. Hispanic/Latino adultsHealthful lifestyle behaviorsCause of deathHealthy lifestyle choicesChronic diseasesCardiovascular diseaseCommon causeCancer riskNarrative reviewBlack adultsDisproportionate burdenObesityCancerAdultsLifestyle choicesDiseasePreventionDeathEffect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Esserman D, Irwin M, Ferrucci L. Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer. JAMA Network Open 2023, 6: e2326463. PMID: 37526937, PMCID: PMC10394582, DOI: 10.1001/jamanetworkopen.2023.26463.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyAerobic exercise interventionAttention control armExercise intervention armExercise interventionOvarian cancerControl armIntervention armSecondary analysisCIPN symptomsPeripheral neuropathyLifestyle StudyTreatment of CIPNModerate-intensity aerobic exerciseStandard oncology careEffects of exerciseSevere adverse effectsBetween-group differencesAmerican Cancer SocietyQuality of lifeAttention controlCIPN severityPrimary outcomeOncology careAerobic exerciseMaximin optimal cluster randomized designs for assessing treatment effect heterogeneity
Ryan M, Esserman D, Li F. Maximin optimal cluster randomized designs for assessing treatment effect heterogeneity. Statistics In Medicine 2023, 42: 3764-3785. PMID: 37339777, PMCID: PMC10510425, DOI: 10.1002/sim.9830.Peer-Reviewed Original ResearchFacilitation and Preferred Models for Delivering Substance Use Disorder Treatment in HIV Clinics: Results From a Multisite Randomized Trial
Muvvala S, Gan G, Morford K, Dziura J, Esserman D, Porter E, Chan P, Cornman D, Reynolds J, Yager J, Fiellin D, Edelman E. Facilitation and Preferred Models for Delivering Substance Use Disorder Treatment in HIV Clinics: Results From a Multisite Randomized Trial. Journal Of Addiction Medicine 2023, 17: e388-e391. PMID: 37934538, PMCID: PMC10726383, DOI: 10.1097/adm.0000000000001192.Peer-Reviewed Original ResearchConceptsOpioid use disorderAlcohol use disorderTobacco use disorderHIV clinicUse disordersAddiction treatmentSubstance use disorder treatmentUse disorder treatmentMaintenance phaseRandomized trialsStaff preferencesImproved outcomesMultisite Randomized TrialImplementation facilitationDisorder treatmentControl phaseClinicCliniciansTreatment modelTreatmentDisordersSignificant differencesInterventionHigher proportionAddiction treatment modelsDesign, implementation and preliminary results of a type-2 hybrid cluster-randomized trial of integrating screening and treatment for major depressive disorder into specialty clinics providing opioid agonist therapies in Ukraine
Machavariani E, Bromberg D, Dumchev K, Dvoriak S, Zeziulin O, Morozova O, Esserman D, Pykalo I, Saichuk N, Ivasiy R, Haddad M, Altice F. Design, implementation and preliminary results of a type-2 hybrid cluster-randomized trial of integrating screening and treatment for major depressive disorder into specialty clinics providing opioid agonist therapies in Ukraine. Contemporary Clinical Trials 2023, 131: 107248. PMID: 37263492, PMCID: PMC10527419, DOI: 10.1016/j.cct.2023.107248.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyMajor depressive disorderCo-occurring disordersAgonist therapyDepressive disorderSpecialty clinicPsychiatric disordersPatient-level outcomesPrevalent psychiatric disordersCluster-randomized trialPoor health outcomesProvider-level dataMDD treatmentTreatment algorithmExperimental armHigh prevalenceDelivery outcomesHealth outcomesSerial surveysClinicPatientsProject ECHOSubstance useMonthsDisordersRental assistance improves food security and nutrition: An analysis of National Survey Data
Denary W, Fenelon A, Whittaker S, Esserman D, Lipska K, Keene D. Rental assistance improves food security and nutrition: An analysis of National Survey Data. Preventive Medicine 2023, 169: 107453. PMID: 36813247, PMCID: PMC10037672, DOI: 10.1016/j.ypmed.2023.107453.Peer-Reviewed Original ResearchConceptsRental assistanceNational quasi-experimental studyFood securityHousing affordability crisisComparable control groupDaily fruitMore cupsProject‐based assistanceEligible individualsVegetable consumptionCurrent unmetControl groupQuasi-experimental studyNational survey dataAffordability crisisHousing accessLong waitlistsAdverse health implicationsHealth implicationsFood insecurityWaitlistAverage wait timeWait timeHealth necessitySurvey dataA qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers
Pichardo M, Irwin M, Sanft T, Ferrucci L, Ginader A, Nguyen T, Esserman D, Cartmel B, Molina Y. A qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers. Supportive Care In Cancer 2023, 31: 111. PMID: 36633678, PMCID: PMC9912693, DOI: 10.1007/s00520-022-07539-9.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsOncology healthcare providersCancer survivorsLifestyle behaviorsHealthcare providersGeneric messagingEvidence-based knowledgeFemale breast cancer survivorsHealthcare provider counselingHealthy lifestyle guidelinesPatient-level barriersHealthy lifestyle behaviorsLifestyle guidelinesProvider counselingLifestyle factorsOncology careCancer outcomesBreast cancerConsistency of evidenceCurrent evidenceAvailable evidenceSurvivorsCancer diagnosisLevel barriersCancerTaking a chance: How likely am I to receive my preferred treatment in a clinical trial?
Walter S, Blaha O, Esserman D. Taking a chance: How likely am I to receive my preferred treatment in a clinical trial? Statistical Methods In Medical Research 2023, 32: 572-592. PMID: 36628522, PMCID: PMC9983058, DOI: 10.1177/09622802221146305.Peer-Reviewed Original ResearchConceptsPatient preference designConcordance ratePreferred treatmentClinical trialsDifferent treatment preferencesProportion of patientsParallel group designPreference designPatient's primary motivationTrial patientsPoor outcomeBlinded trialClinical equipoiseTreatment preferencesTwo-armZelen designAlternative treatmentStudy outcomesStudy designTrialsTreatmentPatientsPotential participantsOutcomesGroup design
2022
Association Between Alcohol Use Disorder and Receipt of Direct-Acting Antiviral Hepatitis C Virus Treatment
Haque L, Fiellin D, Tate J, Esserman D, Bhattacharya D, Butt A, Crystal S, Edelman E, Gordon A, Lim J, Tetrault J, Williams E, Bryant K, Cartwright E, Rentsch C, Justice A, Re V, McGinnis K. Association Between Alcohol Use Disorder and Receipt of Direct-Acting Antiviral Hepatitis C Virus Treatment. JAMA Network Open 2022, 5: e2246604. PMID: 36515952, PMCID: PMC9856353, DOI: 10.1001/jamanetworkopen.2022.46604.Peer-Reviewed Original ResearchConceptsCurrent alcohol use disorderLow-risk drinkingAlcohol use disorderVeterans Health AdministrationHistory of AUDDAA treatmentAlcohol use categoriesAUD historyCohort studyRisk drinkingUse disordersDirect acting antiviral (DAA) treatmentAlcohol Use Disorders Identification Test-Consumption (AUDIT-C) questionnaireHepatitis C virus infectionHepatitis C virus (HCV) treatmentCox proportional hazards regressionC virus infectionC virus treatmentProportional hazards regressionTenth Revision diagnosisAUDIT-C questionnaireInternational Statistical ClassificationRelated Health ProblemsAntiviral treatmentRevision diagnosisContingency management and pre-exposure prophylaxis adherence support services (CoMPASS): A hybrid type 1 effectiveness-implementation study to promote HIV risk reduction among people who inject drugs
Sung M, Viera A, Esserman D, Tong G, Davidson D, Aiudi S, Bailey G, Buchanan A, Buchelli M, Jenkins M, John B, Kolakowski J, Lame A, Murphy S, Porter E, Simone L, Paris M, Rash C, Edelman E. Contingency management and pre-exposure prophylaxis adherence support services (CoMPASS): A hybrid type 1 effectiveness-implementation study to promote HIV risk reduction among people who inject drugs. Contemporary Clinical Trials 2022, 125: 107037. PMID: 36460267, PMCID: PMC9918697, DOI: 10.1016/j.cct.2022.107037.Peer-Reviewed Original ResearchConceptsAdherence support servicesHIV risk reductionPrEP adherenceContingency managementHybrid type 1 effectiveness-implementation trialHIV pre-exposure prophylaxisEffectiveness-implementation studyPre-exposure prophylaxisEffectiveness-implementation trialOpioid use disorderStrengths-based case managementRisk reductionSupport servicesCommunity-based programsPrEP initiationPrimary outcomeWeek 12Clinical trialsHIV preventionUse disordersCM sessionsCase managementBlood spotsPWIDStudy design
2014
The Flipped Classroom
McLaughlin JE, Roth MT, Glatt DM, Gharkholonarehe N, Davidson CA, Griffin LM, Esserman DA, Mumper RJ. The Flipped Classroom. Academic Medicine 2014, 89: 236-243. PMID: 24270916, DOI: 10.1097/acm.0000000000000086.Peer-Reviewed Original ResearchConceptsFlipped classroomLearning experienceClass timeStudent-centered learning activitiesNorth Carolina Eshelman SchoolInquiry-oriented strategiesProblem-based learningStudent learning experienceCurrent educational modelActive learning exercisesStudent learningLearning activitiesEducational modelPharmaceutics courseCurrent curriculumLearning exercisesCourse modelClass attendanceEducational programsStudentsClassroomLearningOnline videosSolution attemptsRecent calls
2013
Physician Decision Making for Colorectal Cancer Screening in the Elderly
Lewis CL, Esserman D, DeLeon C, Pignone MP, Pathman DE, Golin C. Physician Decision Making for Colorectal Cancer Screening in the Elderly. Journal Of General Internal Medicine 2013, 28: 1202-1207. PMID: 23539281, PMCID: PMC3744317, DOI: 10.1007/s11606-013-2393-5.Peer-Reviewed Original ResearchConceptsColorectal cancerCRC screeningOlder patientsPoor healthPatient inputUS primary care physiciansColorectal cancer screeningPrimary care physiciansProportion of physiciansPotential harmScreening recommendationsCare physiciansFemale patientsResultsA totalCancer screeningEligible physiciansOlder womenIndividualized decisionsPatientsOBJECTIVEThe purposePhysician's decisionPhysiciansPotential benefitsOlder adultsGood health
2012
Sample size estimation in educational intervention trials with subgroup heterogeneity in only one arm
Esserman D, Zhao Y, Tang Y, Cai J. Sample size estimation in educational intervention trials with subgroup heterogeneity in only one arm. Statistics In Medicine 2012, 32: 2140-2154. PMID: 23172724, PMCID: PMC3615113, DOI: 10.1002/sim.5678.Peer-Reviewed Original Research
2011
Older US Emergency Department Patients Are Less Likely to Receive Pain Medication Than Younger Patients: Results From a National Survey
Platts-Mills TF, Esserman DA, Brown DL, Bortsov AV, Sloane PD, McLean SA. Older US Emergency Department Patients Are Less Likely to Receive Pain Medication Than Younger Patients: Results From a National Survey. Annals Of Emergency Medicine 2011, 60: 199-206. PMID: 22032803, PMCID: PMC3338876, DOI: 10.1016/j.annemergmed.2011.09.014.Peer-Reviewed Original ResearchConceptsPain-related visitsPain-related ED visitsED visitsPain medicationEmergency departmentPain severityNational Hospital Ambulatory Medical Care SurveyUS emergency department patientsAmbulatory Medical Care SurveyUS ED visitsPercentage of patientsEmergency department patientsUS emergency departmentsRace/ethnicityOpioid administrationYounger patientsDepartment patientsPrimary outcomeVisit codesCare SurveyPatientsAge groupsAnalgesicsMedicationsOlder adults
2007
Maternal, Birth, and Early-Life Influences on Adult Body Size in Women
Terry MB, Wei Y, Esserman D. Maternal, Birth, and Early-Life Influences on Adult Body Size in Women. American Journal Of Epidemiology 2007, 166: 5-13. PMID: 17470452, DOI: 10.1093/aje/kwm094.Peer-Reviewed Original ResearchConceptsAge 20 yearsInfant factorsAdult BMIChildhood growthRapid childhood growthMaternal weight gainAge 40 yearsChildhood growth measuresEarly life influencesImportant predictorPersistence of effectsMaternal BMIBirth measuresBirth weightAge 40BMIEarly infancyMaternal factorsAge 20Weight gainWomenLife influencesLarger womenAge 1Standard statistical methods