Featured Publications
Community factors associated with local epidemic timing of respiratory syncytial virus: A spatiotemporal modeling study
Zheng Z, Pitzer VE, Warren JL, Weinberger DM. Community factors associated with local epidemic timing of respiratory syncytial virus: A spatiotemporal modeling study. Science Advances 2021, 7: eabd6421. PMID: 34162556, PMCID: PMC8221622, DOI: 10.1126/sciadv.abd6421.Peer-Reviewed Original ResearchRespiratory syncytial virusEpidemic timingSyncytial virusRSV epidemicsBayesian meta-regression modelTiming of deliveryMaternal vaccinesMeta-regression modelsHospitalization dataLarge burdenEarly epidemicLarger household sizeYoung childrenTransmission dynamicsZip code levelEpidemicCommunity factorsEpidemic spreadFuture studiesVirusProphylaxisMorbidityVaccineFactors
2024
Workshop on the design and use of clinical trials with multiple endpoints, with a focus on prevention of RSV
Prunas O, Willemsen J, Warren J, Bont L, Schwartz J, Atwell J, Begier E, Dean N, Hirsch I, Karron R, Klugman K, Kramer R, Leidman E, Link-Gelles R, Nair H, Panozzo C, Pelfrene E, Simões E, Smith P, Srikantiah P, Sundaram M, Thindwa D, Vaughn D, Wilson E, Zar H, Pitzer V, Weinberger D. Workshop on the design and use of clinical trials with multiple endpoints, with a focus on prevention of RSV. Vaccine X 2024, 19: 100509. DOI: 10.1016/j.jvacx.2024.100509.Peer-Reviewed Original ResearchRespiratory syncytial virusRandomized controlled trialsPreventive therapyPrevention of respiratory syncytial virusTrial designSuccess of randomized controlled trialsVaccine trial designDesign randomized controlled trialClinical trial designEstimates of vaccine efficacyPrimary endpointSyncytial virusClinical trialsVaccine efficacyControlled trialsMeta-regression modelsSelection of primary endpointsEndpointSequential trial designTherapyMultiple endpointsInteractions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review
Besteman S, Bogaert D, Bont L, Mejias A, Ramilo O, Weinberger D, Dagan R. Interactions between respiratory syncytial virus and Streptococcus pneumoniae in the pathogenesis of childhood respiratory infections: a systematic review. The Lancet Respiratory Medicine 2024, 12: 915-932. PMID: 38991585, DOI: 10.1016/s2213-2600(24)00148-6.Peer-Reviewed Original ResearchRespiratory syncytial virusChildhood respiratory infectionsRespiratory infectionsSyncytial virusStreptococcus pneumoniaeRespiratory syncytial virus vaccineLower respiratory tract infectionsRespiratory tract infectionsSystematic reviewGlobal health burdenYears of ageRSV hospitalisationTract infectionsPneumococcal vaccineSevere diseaseGlobal morbidityEpidemiological associationMonoclonal antibodiesPathogen-pathogen interactionsPneumococciInfectionHealth burdenPathogenesisHost modulationApproaches to disease preventionGlobal patterns of rebound to normal RSV dynamics following COVID-19 suppression
Thindwa D, Li K, Cooper-Wootton D, Zheng Z, Pitzer V, Weinberger D. Global patterns of rebound to normal RSV dynamics following COVID-19 suppression. BMC Infectious Diseases 2024, 24: 635. PMID: 38918718, PMCID: PMC11201371, DOI: 10.1186/s12879-024-09509-4.Peer-Reviewed Original Research
2023
The full value of immunisation against respiratory syncytial virus for infants younger than 1 year: effects beyond prevention of acute respiratory illness
Feikin D, Karron R, Saha S, Sparrow E, Srikantiah P, Weinberger D, Zar H. The full value of immunisation against respiratory syncytial virus for infants younger than 1 year: effects beyond prevention of acute respiratory illness. The Lancet Infectious Diseases 2023, 24: e318-e327. PMID: 38000374, DOI: 10.1016/s1473-3099(23)00568-6.Peer-Reviewed Original ResearchLower respiratory tract infectionsRespiratory syncytial virusRSV diseaseRespiratory illnessSyncytial virusRespiratory diseaseAcute lower respiratory tract infectionPrevention of RSVAcute respiratory illnessRespiratory tract infectionsImportant public health benefitsInappropriate antibiotic useSevere respiratory illnessCause infant mortalityCost-effective interventionPublic health benefitsHealth care systemMaternal vaccinesRecurrent hospitalisationsRSV preventionSecondary pneumoniaTract infectionsMiddle-income countriesLung healthAntibiotic useThe COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study
Dagan R, van der Beek B, Ben-Shimol S, Greenberg D, Shemer-Avni Y, Weinberger D, Danino D. The COVID-19 pandemic as an opportunity for unravelling the causative association between respiratory viruses and pneumococcus-associated disease in young children: a prospective study. EBioMedicine 2023, 90: 104493. PMID: 36857965, PMCID: PMC9970381, DOI: 10.1016/j.ebiom.2023.104493.Peer-Reviewed Original ResearchConceptsCommunity-acquired alveolar pneumoniaLower respiratory infectionsRespiratory syncytial virusInvasive pneumococcal diseaseHuman metapneumovirusDisease endpointsPneumococcal diseaseRespiratory virusesProspective studyNasopharyngeal pneumococcal carriagePneumococcal bacteremic pneumoniaProspective surveillance programRespiratory virus activityCommon respiratory virusesPneumococcal carriage prevalenceBurden of diseaseDifferent clinical endpointsYoung childrenCOVID-19 pandemicProportion of testsAlveolar pneumoniaBacteremic pneumoniaPneumococcal carriageRespiratory infectionsCarriage prevalence
2022
Saliva as an alternative to nasopharyngeal swabs for detection of respiratory syncytial virus (RSV) in children
Langedijk A, Allicock O, Van Wijk M, Yolda-Carr D, Weinberger D, Wyllie A, Bont L. Saliva as an alternative to nasopharyngeal swabs for detection of respiratory syncytial virus (RSV) in children. 2022, 4519. DOI: 10.1183/13993003.congress-2022.4519.Peer-Reviewed Original Research
2021
Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study
Danino D, Ben-Shimol S, Van Der Beek BA, Givon-Lavi N, Avni YS, Greenberg D, Weinberger DM, Dagan R. Decline in Pneumococcal Disease in Young Children During the Coronavirus Disease 2019 (COVID-19) Pandemic in Israel Associated With Suppression of Seasonal Respiratory Viruses, Despite Persistent Pneumococcal Carriage: A Prospective Cohort Study. Clinical Infectious Diseases 2021, 75: e1154-e1164. PMID: 34904635, PMCID: PMC8754767, DOI: 10.1093/cid/ciab1014.Peer-Reviewed Original ResearchConceptsCommunity-acquired alveolar pneumoniaInvasive pneumococcal diseasePneumococcal carriagePneumococcal diseaseRespiratory virusesSurveillance projectCOVID-19 pandemicBacteremic pneumococcal pneumoniaNasopharyngeal pneumococcal carriageSpecific respiratory virusesSARS-CoV-2 casesFirst SARS-CoV-2 caseLower respiratory infectionsProspective cohort studyPneumococcal carriage prevalencePneumococcal serotype distributionRespiratory syncytial virusSeasonal respiratory virusesRespiratory virus detectionChest X-rayDensity of colonizationAlveolar pneumoniaPneumococcal pneumoniaCohort studyRespiratory infectionsEstimation of the Timing and Intensity of Reemergence of Respiratory Syncytial Virus Following the COVID-19 Pandemic in the US
Zheng Z, Pitzer VE, Shapiro ED, Bont LJ, Weinberger DM. Estimation of the Timing and Intensity of Reemergence of Respiratory Syncytial Virus Following the COVID-19 Pandemic in the US. JAMA Network Open 2021, 4: e2141779. PMID: 34913973, PMCID: PMC8678706, DOI: 10.1001/jamanetworkopen.2021.41779.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusRSV epidemicsMathematical modelRSV hospitalizationRSV seasonSyncytial virusSummer epidemicsRSV lower respiratory tract infectionLower respiratory tract infectionsCOVID-19 pandemicLarge RSV outbreaksMaternal-derived immunityRespiratory tract infectionsChildren 1 yearYears of ageSARS-CoV-2Simulation modeling studyProphylaxis administrationRSV circulationRSV infectionRSV outbreaksSecondary outcomesTract infectionsPrimary outcomeLeading cause
2015
Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data
Weinberger DM, Klugman KP, Steiner CA, Simonsen L, Viboud C. Association between Respiratory Syncytial Virus Activity and Pneumococcal Disease in Infants: A Time Series Analysis of US Hospitalization Data. PLOS Medicine 2015, 12: e1001776. PMID: 25562317, PMCID: PMC4285401, DOI: 10.1371/journal.pmed.1001776.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusPneumococcal pneumoniaRate of hospitalizationPneumococcal diseaseHospitalization dataSeven-valent pneumococcal conjugate vaccineBacterial infectionsRespiratory syncytial virus activityLaboratory-confirmed dataPneumococcal pneumonia hospitalizationsPneumococcal conjugate vaccineIntroduction of PCV7Secondary bacterial infectionState Inpatient DatabasesPoisson regression modelsRSV hospitalizationPCV7 introductionPneumonia hospitalizationsConjugate vaccineInpatient DatabaseSyncytial virusPneumococcal septicemiaPneumonia casesEpidemic timingHospitalization