2025
Network structure of psychotic symptoms and childhood trauma in first-episode versus treatment-resistant schizophrenia
Liu Z, Wang X, Deng H, Huang J, Wang J, Chen W, Yang K, Li W, Chen S, Xie T, Liu R, Tian L, Yang F, Tian B, Li Y, Li C, Tan Y. Network structure of psychotic symptoms and childhood trauma in first-episode versus treatment-resistant schizophrenia. Journal Of Psychiatric Research 2025, 185: 31-39. PMID: 40147152, DOI: 10.1016/j.jpsychires.2025.03.037.Peer-Reviewed Original ResearchTreatment-resistant schizophrenia patientsTreatment-resistant schizophreniaFirst-episode schizophreniaPositive and Negative Syndrome ScaleChildhood traumaPsychotic symptomsInfluences psychotic symptomsNegative Syndrome ScaleChildhood Trauma QuestionnaireChildhood trauma experiencesSyndrome ScaleFirst-episodeTrauma QuestionnaireEmotional neglectTraumatic stressTrauma experiencesSchizophreniaSymptom patternsSexual abuseInfluence symptomsSymptom evolutionPartial correlationSymptomsClinical symptomsChildhoodDiminished reward circuit response underlies pain avoidance learning deficits in problem drinkers
Le T, Oba T, Li C. Diminished reward circuit response underlies pain avoidance learning deficits in problem drinkers. NeuroImage Clinical 2025, 45: 103762. PMID: 40009903, PMCID: PMC11908557, DOI: 10.1016/j.nicl.2025.103762.Peer-Reviewed Original ResearchConceptsPosterior cingulate cortexAvoidance learningReward circuitDrinking severityReward deficiencyLearning deficitsPain avoidanceProblem drinkersAlcohol useAvoidance learning deficitMedial orbitofrontal cortexReward circuit dysfunctionVentral tegmental areaPoor avoidance learningAssociated with problem drinkingOrbitofrontal cortexTegmental areaGo/NoGo taskCingulate cortexNeural correlatesBehavioral findingsCircuit dysfunctionAdult drinkersBrain regionsNeural processesNeural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers
Le T, Hughes F, Oba T, Li C. Neural, Motivational, and Psychological Measures of Pain Avoidance Predict Future Alcohol Use in Adult Drinkers. Addiction Biology 2025, 30: e70020. PMID: 39952897, PMCID: PMC11828665, DOI: 10.1111/adb.70020.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexDrinking motivesAlcohol usePsychological measuresPercentage of heavy drinking daysRisk of alcohol use disorderAlcohol use severityAnterior cingulate cortexHeavy drinking daysAlcohol use disorderPain-related psychological measuresParticipants' alcohol usePromote alcohol usePainful electric shocksLevels of drinkingPain sensitivityAlcohol cravingDrinking severityGo/NoGo taskCingulate cortexNeural correlatesDrinking daysUse disorderAdult drinkersOvert actionsHypothalamic resting-state functional connectivity and self-evaluated aggression in young adults
Yao Y, Chen Y, Li C. Hypothalamic resting-state functional connectivity and self-evaluated aggression in young adults. Journal Of Psychiatric Research 2025, 182: 421-429. PMID: 39889403, PMCID: PMC11834083, DOI: 10.1016/j.jpsychires.2025.01.045.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAggression scoresLateral hypothalamusSex differencesHuman Connectome ProjectFunctional connectivityAchenbach Adult Self-ReportAdult Self-ReportYoung adultsManifestations of aggressionVoxel-wise regressionPublished routinesMotivated behaviorOccipital gyriAggressive behaviorSelf-reportMental healthAggressionConnectome ProjectNeural pathwaysBehavioral traitsRSFCHypothalamusScoresAdultsPhenome-wide association studies between SERINC2 and neuropsychiatric disorders
Liu P, Luo X, Cao L, Zhang Y, Ji J, Wang X, Wang K, Pan X, Yang R, Tan Z, Tan Y, Li C, Guo X, Wang Z, Luo X. Phenome-wide association studies between SERINC2 and neuropsychiatric disorders. Frontiers In Psychiatry 2025, 15: 1420395. PMID: 39902246, PMCID: PMC11788846, DOI: 10.3389/fpsyt.2024.1420395.Peer-Reviewed Original ResearchGray matter volumeBipolar disorderNeuropsychiatric disordersDisease-risk alleleSubcortical gray matter volumesSubstance use disordersMRNA expressionCortical surface areaAssociated with alcoholCocaine dependenceMarijuana dependencePolysubstance dependenceMatter volumeNicotine dependenceBrain regionsSchizophreniaSubcortical structuresSNP-disease associationsPhenome-wide association studyAutismOCDFDR correctionDisordersRegulatory effectsAssociation studiesPolygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults
Chen Y, Li H, Luo X, Li G, Ide J, Li C. Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults. Journal Of Psychiatry And Neuroscience 2025, 50: e31-e44. PMID: 39809531, PMCID: PMC11737878, DOI: 10.1503/jpn.240087.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityPolygenic risk scoresSubgenual anterior cingulate cortexAnterior cingulate cortexDepression severityCingulate cortexSubclinical depressionHealthy young adultsSomatic complaintsYoung adultsPolygenic riskAssociated with depression severitySeverity of somatic complaintsSeverity of depressive symptomsAssociated with polygenic riskWhole-brain regressionAlcohol use severityMarkers of depressionManifestations of depressionHuman Connectome ProjectDepressive disorderSubclinical populationsMode networkDepressive symptomsBrain structures
2024
N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia
Tong J, Yang K, Li W, Wang L, Yin Y, Zhou Y, Huang J, Zhang P, Zhao Y, Chen S, Fan H, Cui Y, Luo X, Tan S, Wang Z, Feng W, Tian B, Li C, Hong L, Tan Y. N-Methyl-d-Aspartate Receptor Antibody and Sensory Gating Deficits in Non-smoking, Minimal Antipsychotic Medication Exposure, and First-Episode Patients With Schizophrenia. Schizophrenia Bulletin 2024, sbae180. PMID: 39406395, DOI: 10.1093/schbul/sbae180.Peer-Reviewed Original ResearchFirst-episode schizophreniaSensory gating deficitsN-methyl-D-aspartate receptorsFirst-episode schizophrenia groupGating deficitsN-methyl-D-aspartateP50 ratioSensory gatingExposure to antipsychotic medicationAb levelsHealthy controlsAntipsychotic medication exposureFirst-episode patientsDiagnosis of schizophreniaImpaired sensory gatingP50 sensory gating deficitN-methyl-D-aspartate receptor antibodiesAntipsychotic medicationFirst-episodeNon-smoking healthy controlsP50 differenceSchizophreniaPartial correlation analysisEnzyme-linked immunosorbent assayDeficitsImpulsivity Impacts Suicidality in Patients with Alcohol Use Disorder with and without Comorbid Depression
Wang V, Liao D, Wu E, Li C. Impulsivity Impacts Suicidality in Patients with Alcohol Use Disorder with and without Comorbid Depression. Taiwanese Journal Of Psychiatry 2024, 38: 171-176. DOI: 10.4103/tpsy.tpsy_31_24.Peer-Reviewed Original ResearchBarratt Impulsiveness ScaleAlcohol use disorderSuicide attemptsUse disorderSuicidal tendenciesBarratt Impulsiveness Scale total scoreBarratt Impulsiveness Scale scoresHistory of suicide attemptsAlcohol use disorder patientsSeverity of alcohol useAssessment of impulsivityAlcohol use severitySeverity of depressionSuicide prevention effortsBarratt impulsivityImpulsiveness ScaleDepressive disorderNondepressed individualsAnxiety comorbiditiesAssess suicidalityDepression severityComorbid depressionHigher suicidalityPsychiatric comorbiditiesSevere alcoholismDrinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study
Li G, Dong Y, Chen Y, Li B, Chaudhary S, Bi J, Sun H, Yang C, Liu Y, Li C. Drinking severity mediates the relationship between hypothalamic connectivity and rule-breaking/intrusive behavior differently in young women and men: an exploratory study. Quantitative Imaging In Medicine And Surgery 2024, 14: 6669683-6666683. PMID: 39281112, PMCID: PMC11400642, DOI: 10.21037/qims-24-815.Peer-Reviewed Original ResearchLeft temporo-parietal junctionHypothalamic connectionsIntrusion scoresParacentral lobuleAlcohol misuseAdult Self-Report ScaleSeverity of alcohol useSeverity of alcohol misuseTemporo-parietal junctionWhole-brain regressionSeverity of drinkingSelf-report scalesHypothalamic functional connectivityImpact of problem drinkingMotivational circuitsDrinking severityHuman Connectome ProjectMotivated behaviorDrinking measuresFunctional connectivityMediation analysisProblem drinkingRule-breakingAlcohol useNeural circuitsProgressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia
Li X, Zeng J, Liu N, Yang C, Tao B, Sun H, Gong Q, Zhang W, Li C, Lui S. Progressive alterations of resting-state hypothalamic dysconnectivity in schizophrenia. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2024, 135: 111127. PMID: 39181307, DOI: 10.1016/j.pnpbp.2024.111127.Peer-Reviewed Original ResearchHypothalamic functional connectivityBilateral anterior cingulate cortexAnterior cingulate cortexFunctional connectivityFES patientsCingulate cortexFC decreaseRight thalamusChronically treated schizophrenia patientsHealthy controlsSeed-based functional connectivityFirst-episode patientsPathogenesis of schizophreniaNature of schizophreniaAge-related declineAntipsychotic treatmentAntipsychotic medicationRight caudateLeft putamenIllness durationAnalysis of covarianceSchizophreniaDiagnostic groupsHC groupHypothalamus dysfunctionNeural correlates of proactive avoidance deficits and alcohol use motives in problem drinking
Le T, Oba T, Couch L, McInerney L, Li C. Neural correlates of proactive avoidance deficits and alcohol use motives in problem drinking. Translational Psychiatry 2024, 14: 336. PMID: 39168986, PMCID: PMC11339324, DOI: 10.1038/s41398-024-03039-y.Peer-Reviewed Original ResearchConceptsAvoidance deficitNegative emotionsDrinking motivesAlcohol useNeural correlatesProblem drinkingRight anterior insula activityAssociated with greater alcohol useAnterior insula activityAlcohol use motivesGreater alcohol useProblem drinking groupInfluence alcohol usePhysical painInsula activationDrinking severityGo/NoGo taskNeural underpinningsPutamen responseSocial drinkersBehavioral measuresAvoidance performanceBehavioral resultsFunctional connectivityDrinking behaviorThe inter-related effects of alcohol use severity and sleep deficiency on semantic processing in young adults
Li G, Zhong D, Zhang N, Dong J, Yan Y, Xu Q, Xu S, Yang L, Hao D, Li C. The inter-related effects of alcohol use severity and sleep deficiency on semantic processing in young adults. Neuroscience 2024, 555: 116-124. PMID: 39059740, DOI: 10.1016/j.neuroscience.2024.07.025.Peer-Reviewed Original ResearchMiddle frontal gyrusSemantic processingPittsburgh Sleep Quality IndexPrecentral gyrusPittsburgh Sleep Quality Index scoreAlcohol misuseNeural correlates of semantic processingMiddle frontal gyrus activationRight middle frontal gyrusSeverity of alcohol useAlcohol use severityAssociated with deficitsPrecentral gyrus activationLeft precentral gyrusInfluence of sleep qualityYoung adultsWord comprehensionHuman Connectome Project dataFrontal gyrusNeural correlatesConsumption severityLanguage tasksSleep deficiencyNeural mechanismsMediation analysisAge-related reduction in anxiety and neural encoding of negative emotional memory
Chaudhary S, Zhang S, Chen Y, Dominguez J, Chao H, Li C. Age-related reduction in anxiety and neural encoding of negative emotional memory. Frontiers In Aging Neuroscience 2024, 16: 1375435. PMID: 39021704, PMCID: PMC11252031, DOI: 10.3389/fnagi.2024.1375435.Peer-Reviewed Original ResearchNegative emotional memoriesSpielberger State-Trait Anxiety InventoryEmotional memoryAge-related reductionSpielberger State-Trait Anxiety Inventory scoresWhole-brain regressionNegative emotional imagesState-Trait Anxiety InventoryTrait Anxiety InventoryAge-related differencesSignal detection theoryMemory taskNeutral imagesAge-related changesEmotional imagesAnxiety InventoryMediation analysisAnxietyPost-scanCortical activityNeural encodingState scoresMemoryOlder adultsDetection theoryRelationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia
Wang X, Chen W, Gou M, Li W, Li N, Tong J, Zhou Y, Xie T, Yu T, Feng W, Li Y, Chen S, Tian B, Tan S, Wang Z, Pan S, Luo X, Zhang P, Huang J, Tian L, Li C, Tan Y. Relationship between plasma TNF-α levels and agitation symptoms in first episode patients with schizophrenia. BMC Psychiatry 2024, 24: 480. PMID: 38956509, PMCID: PMC11218378, DOI: 10.1186/s12888-024-05796-y.Peer-Reviewed Original ResearchConceptsPositive and Negative Syndrome ScalePlasma TNF-a levelsAgitation symptomsPANSS-ECEpisode patientsTNF-a levelsPositive and Negative Syndrome Scale total scorePANSS-EC scoreNegative Syndrome ScaleSymptoms of schizophreniaPathophysiology of schizophreniaEnzyme-linked immunosorbent assayTNF-aR1 levelSyndrome ScalePlasma levels of tumor necrosis factor-alphaLevels of tumor necrosis factor-alphaSchizophreniaTotal scoreTumor necrosis factor-alphaNecrosis factor-alphaPlasma TNF-aHealthy controlsFEPImmune abnormalitiesSex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory
Li G, Cao Y, Yang C, Li X, Yang Y, Yang L, Hao D, Li C. Sex differences in dorsolateral prefrontal cortical and superior colliculus activities support the impact of alcohol use severity and sleep deficiency on two-back memory. Quantitative Imaging In Medicine And Surgery 2024, 14: 4972986-4974986. PMID: 39022273, PMCID: PMC11250293, DOI: 10.21037/qims-24-156.Peer-Reviewed Original ResearchAlcohol use severityWorking memoryPittsburgh Sleep Quality IndexAlcohol misuseSex differencesHuman Connectome ProjectPath modelAssociated with working memory deficitsNeural correlates of working memoryPittsburgh Sleep Quality Index scoreCorrelates of working memoryPrefrontal cortex responsesImpact working memoryWhole-brain regressionComorbid alcohol misusePotential sex differencesManipulation of informationImpact of drinkingDLPFC activationDrinking severityPublished routinesNeural correlatesMemory deficitsNeural measuresSleep deficiencyPhenome-wide association studies of TXNRD2-COMT-ARVCF cluster pinpoint schizophrenia and bipolar disorder
Guo X, Luo X, Zhang Y, Yu Z, Tan Z, Cao L, Ji J, Wang X, Wang K, Wang Z, Li C, Tan Y, Luo X. Phenome-wide association studies of TXNRD2-COMT-ARVCF cluster pinpoint schizophrenia and bipolar disorder. Asian Journal Of Psychiatry 2024, 98: 104145. PMID: 38959548, DOI: 10.1016/j.ajp.2024.104145.Peer-Reviewed Original ResearchGray matter volumetric correlates of the polygenic risk of depression: A study of the Human Connectome Project data
Fu X, Chen Y, Luo X, Ide J, Li C. Gray matter volumetric correlates of the polygenic risk of depression: A study of the Human Connectome Project data. European Neuropsychopharmacology 2024, 87: 2-12. PMID: 38936229, DOI: 10.1016/j.euroneuro.2024.06.004.Peer-Reviewed Original ResearchGray matter volumeRegional gray matter volumeGenetic risk of depressionPhenotype of depressionPolygenic risk scoresVoxel-based morphometryRisk of depressionAchenbach Adult Self-ReportRight cerebellum crus ICerebellar gray matter volumeAnterior cingulate volumesPathophysiology of depressionAnterior cingulate cortexCerebellum crus IDSM-oriented scalesMarkers of depressionLeft postcentral gyrusAdult Self-ReportRight gyrus rectusGenetic riskNeural endophenotypesHuman Connectome Project dataDrinking severityHuman Connectome ProjectCingulate volumesFunctional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking
Li Y, Yang L, Hao D, Chen Y, Ye-Lin Y, Li C, Li G. Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking. Brain Sciences 2024, 14: 610. PMID: 38928610, PMCID: PMC11201596, DOI: 10.3390/brainsci14060610.Peer-Reviewed Original ResearchConnectome-based predictive modelingAlcohol use severityReward processingPunishment processingFunctional connectivityAssociated with alcohol use severityAlcohol misusePatterns of network connectivitySemi-Structured AssessmentYoung adult drinkersYoung adultsGenetics of AlcoholismYoung adult drinkingHuman Connectome Project dataNetwork connectivity featuresFronto-parietalAdult drinkersJuSpace toolboxAdult drinkingNeural fingerprintsMolecular profilingGABAA signalingRewardFunctional networksConnectivity featuresImmunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia
Li N, Li Y, Yu T, Gou M, Chen W, Wang X, Tong J, Chen S, Tan S, Wang Z, Tian B, Li C, Tan Y. Immunosenescence-related T cell phenotypes and white matter in schizophrenia patients with tardive dyskinesia. Schizophrenia Research 2024, 269: 36-47. PMID: 38723519, DOI: 10.1016/j.schres.2024.04.017.Peer-Reviewed Original ResearchCD95+ T cellsTardive dyskinesiaT-cell phenotypeT cell subpopulationsBrain structural abnormalitiesT cellsSchizophrenia patientsFractional anisotropyCD95+Distribution of T cell phenotypesStructural abnormalitiesAssociated with brain structural abnormalitiesMemory T-cell subpopulationsCD8+ T cellsLevels of IFN-gInferior fronto-occipital fasciculusLevels of cytokinesSuperior longitudinal fasciculusFronto-occipital fasciculusChoroid plexus volumeIntracellular levelsWhite matter tractsOrofacial TDPallidum volumesPublished routinesPremature Ovarian Insufficiency Is Associated with Increased Risk of Depression, Anxiety, and Poor Life Quality: A Systematic Review and Meta-analysis
Tian Y, Department of Human Reproductive Medicine B, Zhang X, Xin Z, Li C, Zhang F, Deng H, Yang X, Department of Psychology C, Department of Psychiatry Y, Global Clinical and Translational Research Institute B, Peking University Huilongguan Clinical Medical School B. Premature Ovarian Insufficiency Is Associated with Increased Risk of Depression, Anxiety, and Poor Life Quality: A Systematic Review and Meta-analysis. Anatolian Journal Of Psychiatry 2024, 25: 132-141. PMID: 38798816, DOI: 10.5152/alphapsychiatry.2024.231501.Peer-Reviewed Original ResearchRisk of depressionHealth of womenPoor life qualityPsychosocial problemsMental healthMeta-analysisOdds ratioRisk of mental health problemsAssociated with increased risk of depressionMental health of womenIncreased risk of depressionLife qualityWomen's mental healthMental health problemsPremature ovarian insufficiencyPooled odds ratioAssociated with increased riskReproductive health of womenUnmarried statusEgger's testMarital statusPublication biasSystematic reviewHealth problemsSystematic search