2022
Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth
Mulligan CJ, Clukay CJ, Matarazzo A, Hadfield K, Nevell L, Dajani R, Panter-Brick C. Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth. PLOS ONE 2022, 17: e0266509. PMID: 35377919, PMCID: PMC8979449, DOI: 10.1371/journal.pone.0266509.Peer-Reviewed Original ResearchConceptsProtective effectTrauma exposureHealth-focused interventionsGenetic variantsDirect protective effectAltered stress reactivityLifetime trauma exposureEarly life adversityPost-traumatic stress symptomsHigh expression variantsOutcome measuresControl studyPsychosocial stressGene x environment interactionsHealth trajectoriesLife adversityMental healthTime pointsWar-related traumaStress reactivityTraumaHigh levelsLongitudinal studyEffects of geneticsPsychosocial environment
2019
Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees
Clukay CJ, Dajani R, Hadfield K, Quinlan J, Panter-Brick C, Mulligan CJ. Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees. PLOS ONE 2019, 14: e0219385. PMID: 31314763, PMCID: PMC6636744, DOI: 10.1371/journal.pone.0219385.Peer-Reviewed Original ResearchConceptsPsychosocial stressPerceived Stress ScaleTrauma exposureProtective factorsGenetic variantsLow trauma exposureHigh trauma exposureMental health measuresMental health trajectoriesAdult mental healthSymptom scoresPsychosocial healthPsychosocial factorsEarly childhood traumaHealth measuresHealth trajectoriesMental healthTraumaMonoamine oxidaseTime pointsPsychosocial wellbeingLifelong effectsChildhood traumaHigher resilience levelsLongitudinal study