Featured Publications
Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System
Gu T, Mack J, Salvatore M, Sankar S, Valley T, Singh K, Nallamothu B, Kheterpal S, Lisabeth L, Fritsche L, Mukherjee B. Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System. JAMA Network Open 2020, 3: e2025197. PMID: 33084902, PMCID: PMC7578774, DOI: 10.1001/jamanetworkopen.2020.25197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBetacoronavirusBlack or African AmericanComorbidityCoronavirus InfectionsCOVID-19Diabetes Mellitus, Type 2FemaleHealth Status DisparitiesHospitalizationHumansIntensive Care UnitsKidney DiseasesMaleMichiganMiddle AgedNeoplasmsObesityOdds RatioPandemicsPneumonia, ViralPopulation DensityRetrospective StudiesRisk FactorsSARS-CoV-2White PeopleConceptsAssociated with higher riskInternational Classification of DiseasesRisk of hospitalizationPreexisting type 2 diabetesHigher risk of hospitalizationClassification of DiseasesType 2 diabetesCOVID-19 outcomesRacial/ethnic disparitiesWhite patientsBlack patientsIntensive care unitInternational ClassificationResidential-level socioeconomic characteristicsOdds ratioStatistically significant racial differencesHigh riskAssociated with higher risk of hospitalizationNon-Hispanic blacksAssociation of risk factorsNon-Hispanic whitesMichigan Department of HealthAssociated with increased risk of hospitalizationComorbidity scoreDepartment of Health
2022
Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey
Roberts E, Boss J, Mukherjee B, Salerno S, Zota A, Needham B. Persistent organic pollutant exposure contributes to Black/White differences in leukocyte telomere length in the National Health and Nutrition Examination Survey. Scientific Reports 2022, 12: 19960. PMID: 36402910, PMCID: PMC9675834, DOI: 10.1038/s41598-022-24316-0.Peer-Reviewed Original ResearchConceptsNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyPersistent organic pollutantsLeukocyte telomere lengthNutrition Examination SurveyToxic equivalent quotientPolychlorinated biphenylsBlack/white differencesExamination SurveyCross-sectional National Health and Nutrition Examination SurveyNon-Hispanic Black AmericansExposure scoreNon-Hispanic white AmericansSurvey-weighted linear regression modelsIndirect effects of raceAssociated with longer leukocyte telomere lengthSingle-pollutant modelsIndividual persistent organic pollutantsExposure to polychlorinated biphenylsLonger leukocyte telomere lengthSelf-reported racePersistent organic pollutant exposuresBlack AmericansIndividual polychlorinated biphenylOrganic pollutant exposures
2020
Incidence and survival of inflammatory breast cancer between 1973 and 2015 in the SEER database
Abraham H, Xia Y, Mukherjee B, Merajver S. Incidence and survival of inflammatory breast cancer between 1973 and 2015 in the SEER database. Breast Cancer Research And Treatment 2020, 185: 229-238. PMID: 33033965, DOI: 10.1007/s10549-020-05938-2.Peer-Reviewed Original ResearchConceptsSurvival timeBlack patientsBreast cancerWhite patientsSurvival rateIncidence rateIncidence of IBCInflammatory breast cancerPurposeInflammatory breast cancerResultsThe overall incidenceAge-adjusted incidence ratesMean survival timeRelative survival ratesIBC patientsT stageAggressive variantSkin progressionNo significant differenceDisease criteriaSurvival disparitiesPatientsSignificant differenceSurvivalConfidence intervalsMonthsDo black/white differences in telomere length depend on socioeconomic status?
Needham B, Salerno S, Roberts E, Boss J, Allgood K, Mukherjee B. Do black/white differences in telomere length depend on socioeconomic status? Biodemography And Social Biology 2020, 65: 287-312. PMID: 33243026, PMCID: PMC7703670, DOI: 10.1080/19485565.2020.1765734.Peer-Reviewed Original ResearchConceptsUS blacksNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyNutrition Examination SurveyAccelerated biological agingLeukocyte telomere lengthLonger telomere lengthExamination SurveyRisk of diseaseSocioeconomic statusHigher SESLow SESMiddle SESBlack/white differencesTelomere lengthRace differencesSESEconomic disadvantageBiological ageWhiteGenetic explanationBlackHealthDifferencesSurveyA Fast and Accurate Method for Genome-Wide Time-to-Event Data Analysis and Its Application to UK Biobank
Bi W, Fritsche L, Mukherjee B, Kim S, Lee S. A Fast and Accurate Method for Genome-Wide Time-to-Event Data Analysis and Its Application to UK Biobank. American Journal Of Human Genetics 2020, 107: 222-233. PMID: 32589924, PMCID: PMC7413891, DOI: 10.1016/j.ajhg.2020.06.003.Peer-Reviewed Original ResearchConceptsControlled type I error ratesTime-to-event data analysisType I error rateGenetic studies of human diseasesGenome-wide significance levelTime-to-event phenotypesSaddlepoint approximationGenome-wide analysisEuropean ancestry samplesMinor allele frequencyStudy of human diseaseElectronic health recordsCox PH regression modelRegression modelsStandard Wald testProportional hazardsBinary phenotypesData analysisAncestry samplesGenetic studiesHealth recordsUK BiobankAllele frequenciesInpatient dataCox proportional hazards
2019
Urinary metals and metal mixtures in midlife women: The Study of Women's Health Across the Nation (SWAN)
Wang X, Mukherjee B, Batterman S, Harlow S, Park S. Urinary metals and metal mixtures in midlife women: The Study of Women's Health Across the Nation (SWAN). International Journal Of Hygiene And Environmental Health 2019, 222: 778-789. PMID: 31103473, PMCID: PMC6583796, DOI: 10.1016/j.ijheh.2019.05.002.Peer-Reviewed Original ResearchConceptsMultiple metalsMetal mixturesExposure to multiple metalsExposure patternsConcentrations of metalsExposure to metalsConsumption of seafoodHigh-resolution inductively coupled plasma mass spectrometryInductively coupled plasma mass spectrometryMeasured urinary concentrationsGeometric mean concentrationsMetal exposurePlasma mass spectrometrySeafood intakeUrinary metalsMean concentrationsRice intakeSeafoodUrinary concentrationsDetectable concentrationHigher exposuresGeographical characteristicsMercuryLead levelsMetal
2016
Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans
Basa R, Davies V, Li X, Murali B, Shah J, Yang B, Li S, Khan M, Tian M, Tejada R, Hassan A, Washington A, Mukherjee B, Carethers J, McGuire K. Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. PLOS ONE 2016, 11: e0156660. PMID: 27310868, PMCID: PMC4911070, DOI: 10.1371/journal.pone.0156660.Peer-Reviewed Original ResearchConceptsGranzyme B+ cellsColorectal cancerCytotoxic immunityB+ cellsAnti-tumor cytotoxic T lymphocytesColon cancerMicrosatellite-stable colon cancerCytotoxic T lymphocytesIL-17 expressionWilcoxon rank sum testProtection to patientsAfrican American colorectal cancerRank sum testTwo-sample Wilcoxon rank-sum testCD57+CD8+Invasive borderCytotoxic markersNo significant differenceT lymphocytesColon tumorsDescriptive summary statisticsImmune biomarkersTumor samplesImmune cytotoxicity
2015
Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis
Ware E, Mukherjee B, Sun Y, Diez-Roux A, Kardia S, Smith J. Comparative genome-wide association studies of a depressive symptom phenotype in a repeated measures setting by race/ethnicity in the multi-ethnic study of atherosclerosis. BMC Genomic Data 2015, 16: 118. PMID: 26459564, PMCID: PMC4603946, DOI: 10.1186/s12863-015-0274-0.Peer-Reviewed Original ResearchConceptsMulti-Ethnic StudyGenome-wide association studiesStudies of depressive symptomsMulti-Ethnic Study of AtherosclerosisDepressive symptomsStudy of AtherosclerosisGenome-wide suggestive levelMeasures analysisSingle-nucleotide polymorphismsMultiple ethnicitiesBaseline measurementsMeta-analysisEuropean AmericansLongitudinal measurementsGenome-wide analysisLongitudinal frameworkSuggestive levelAssociation studiesMethodsThis studyEthnicityGenetic predictorsP-valueMood disordersHealthNovel variantsLife course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis
Needham B, Smith J, Zhao W, Wang X, Mukherjee B, Kardia S, Shively C, Seeman T, Liu Y, Roux A. Life course socioeconomic status and DNA methylation in genes related to stress reactivity and inflammation: The multi-ethnic study of atherosclerosis. Epigenetics 2015, 10: 958-969. PMID: 26295359, PMCID: PMC4844216, DOI: 10.1080/15592294.2015.1085139.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisAssociated with DNA methylationSocioeconomic statusStress-related genesMulti-Ethnic StudyStudy of AtherosclerosisDNA methylationLow adult socioeconomic statusLife course socioeconomic statusLow childhood socioeconomic statusMeasures of socioeconomic statusAdult socioeconomic statusSocial patterning of diseaseChildhood socioeconomic statusGene expressionLow socioeconomic statusLife course measuresAssociated with gene expressionInflammation-related genesFunctional consequences of alterationsDNA methylation measurementsNon-HispanicHispanic participantsPotential functional consequencesEpigenetic dataAssociation between Stress Response Genes and Features of Diurnal Cortisol Curves in the Multi-Ethnic Study of Atherosclerosis: A New Multi-Phenotype Approach for Gene-Based Association Tests
He Z, Payne E, Mukherjee B, Lee S, Smith J, Ware E, Sánchez B, Seeman T, Kardia S, Roux A. Association between Stress Response Genes and Features of Diurnal Cortisol Curves in the Multi-Ethnic Study of Atherosclerosis: A New Multi-Phenotype Approach for Gene-Based Association Tests. PLOS ONE 2015, 10: e0126637. PMID: 25993632, PMCID: PMC4439141, DOI: 10.1371/journal.pone.0126637.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisMarker association testsCortisol featuresMulti-Ethnic StudySingle marker association testsStudy of AtherosclerosisAssociation TestGene level association testsGene-based association testsEthnic-specific resultsMeta-analysisGenetic contribution to variabilityGene-level analysisStress-responsive genesSample of European AmericansGenotype-phenotype associationsDiurnal cortisol curveHispanic AmericansChronic diseasesMultiple physiological systemsDaily cortisol profilesAfrican AmericansGene approachGene-basedMultiple testing