2024
Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico
Kim C, Cathey A, Park S, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Associations of maternal blood metal concentrations with plasma eicosanoids among pregnant women in Puerto Rico. The Science Of The Total Environment 2024, 928: 172295. PMID: 38588744, DOI: 10.1016/j.scitotenv.2024.172295.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesSex-specific associationsBirth outcomesBlood metal concentrationsMetal concentrationsPregnant womenInfant sexEicosanoid profileMetal exposurePlasma eicosanoidsWeeks of pregnancyDecreased concentrations of CdConcentrations of CdConcentrations of CuEffect modificationRegulating inflammatory responsesBirth cohortAssessed associationsAssociated with increased concentrationsPregnancy outcomesFemale fetusesEffect sizeInflammatory activitySignificant associationInflammatory response
2022
Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN)
Wang X, Ding N, Harlow S, Randolph J, Mukherjee B, Gold E, Park S. Exposure to heavy metals and hormone levels in midlife women: The Study of Women's Health Across the Nation (SWAN). Environmental Pollution 2022, 317: 120740. PMID: 36436662, PMCID: PMC9897061, DOI: 10.1016/j.envpol.2022.120740.Peer-Reviewed Original ResearchConceptsUrinary metal concentrationsExposure to heavy metalsHeavy metalsMetal concentrationsStudy of Women's HealthAssociation of heavy metalsEnvironmental heavy metal exposureHeavy metal exposureSex hormone-binding globulinFollicle-stimulating hormoneWomen's HealthBayesian kernel machine regressionAssociated with E<sub>2</sub>, TMidlife womenKernel machine regressionMetal exposureSerum hormone levelsMetal mixturesHealth-related factorsNation Multi-Pollutant StudyCalculate percent changesCadmiumHormone levelsProspective cohort studyLinear mixed effects modelsMaternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico
Kim C, Cathey A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal blood metal concentrations are associated with matrix metalloproteinases (MMPs) among pregnant women in Puerto Rico. Environmental Research 2022, 209: 112874. PMID: 35123972, PMCID: PMC10443181, DOI: 10.1016/j.envres.2022.112874.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansMaleMaternal ExposureMatrix MetalloproteinasesMetals, HeavyPregnancyPuerto RicoConceptsBlood metal concentrationsAdverse birth outcomesMetal concentrationsAssociated with matrix metalloproteinasesMatrix metalloproteinasesBirth outcomesFetal sexHealthy pregnancyLinear mixed effects modelsUterine remodelingPregnant womenFemale fetusesExposure to heavy metalsHeavy metal exposureCustomized Luminex assayFetal sex effectLevels of inflammatory cytokinesTrimester of pregnancyBlood metal levelsMetal levelsHeavy metalsMetal exposureMeasured blood concentrationsLuminex assayMale fetusesMaternal Metals/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico
Kim C, Ashrap P, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal Metals/Metalloid Blood Levels Are Associated With Lipidomic Profiles Among Pregnant Women in Puerto Rico. Frontiers In Public Health 2022, 9: 754706. PMID: 35096734, PMCID: PMC8790322, DOI: 10.3389/fpubh.2021.754706.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesBlood levelsPlasmenyl-phosphatidylcholinesLipidomic profilesBirth outcomesPlasmenyl phosphatidylethanolamineWeeks of pregnancyPlasma lipidomic profilesMultiple comparisonsLipid sub-classesHeavy metal exposurePolyunsaturated fatty acidsPregnant womenShotgun lipidomicsMetal exposureImportant signaling pathwaysAssessed associationsBiomarker profilesAssociated with lipidEarly detectionBirth cohortDiagnostic toolExposure to manganeseSignaling pathwayFalse discovery rate
2021
Urinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Harlow S, Park S. Urinary Heavy Metals and Longitudinal Changes in Blood Pressure in Midlife Women: The Study of Women’s Health Across the Nation. Hypertension 2021, 78: 543-551. PMID: 34148361, PMCID: PMC8266752, DOI: 10.1161/hypertensionaha.121.17295.Peer-Reviewed Original Research
2020
Predictors of urinary and blood Metal(loid) concentrations among pregnant women in Northern Puerto Rico
Ashrap P, Watkins D, Mukherjee B, Boss J, Richards M, Rosario Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Predictors of urinary and blood Metal(loid) concentrations among pregnant women in Northern Puerto Rico. Environmental Research 2020, 183: 109178. PMID: 32007748, PMCID: PMC7167342, DOI: 10.1016/j.envres.2020.109178.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArsenicChromiumFemaleHumansMaternal ExposureMetalsMetals, HeavyPregnancyPuerto RicoTrace ElementsConceptsBlood concentrations of CuTrace metal exposureConcentrations of CuExposure reduction strategiesBiomarkers of exposureBlood HgMetalloid exposureMetal exposureNorthern Puerto RicoBlood CdTrace metalsBlood PbRice consumptionExposure sourcesPuerto RicoMetal(loid)sMetal(loidExposure assessmentBiomarker variationsPbPublic waterZnFishMnMetal
2018
Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014
Wang X, Mukherjee B, Park S. Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014. Environment International 2018, 121: 683-694. PMID: 30316184, PMCID: PMC6268112, DOI: 10.1016/j.envint.2018.09.035.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreAssociated with obesityHeavy metal mixturesHeavy metalsMetal mixturesAssociation of cumulative exposureCumulative exposureComplex survey designEffects of cumulative exposurePhysical activityObesity measuresAdaptive elastic-netChronic conditionsExposure to heavy metalsInteraction of heavy metalsWaist circumferenceTotal body fatNHANES cyclesU.S. adultsEpidemiological researchType 2 diabetes mellitusCorrelated heavy metalSmoking statusHigher BMISkinfold thickness
2014
The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures
Morishita M, Bard R, Wang L, Das R, Dvonch J, Spino C, Mukherjee B, Sun Q, Harkema J, Rajagopalan S, Brook R. The characteristics of coarse particulate matter air pollution associated with alterations in blood pressure and heart rate during controlled exposures. Journal Of Exposure Science & Environmental Epidemiology 2014, 25: 153-159. PMID: 25227729, PMCID: PMC4462122, DOI: 10.1038/jes.2014.62.Peer-Reviewed Original ResearchConceptsCoarse PMPM massEffects of coarse PMCoarse PM massAmbient coarse PMRural locationsSystolic BPMetrics of exposureBlood pressurePotential health effectsHeart ratePM elementsElevated systolic BPFiltered airAerodynamic diameterDiastolic BP changesMixed model analysisConcentration-response mannerParticulate massFilter samplesParticle constituentsDiastolic BPMeasured elementsHealthy adultsAssociated with similar degrees