2021
Associations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife women
Ding N, Karvonen-Gutierrez C, Herman W, Calafat A, Mukherjee B, Park S. Associations of perfluoroalkyl and polyfluoroalkyl substances (PFAS) and PFAS mixtures with adipokines in midlife women. International Journal Of Hygiene And Environmental Health 2021, 235: 113777. PMID: 34090141, PMCID: PMC8207532, DOI: 10.1016/j.ijheh.2021.113777.Peer-Reviewed Original ResearchConceptsBayesian kernel machine regressionNormal weightStudy of Women's HealthCirculating levels of leptinHMW adiponectinBayesian kernel machine regression analysisSoluble leptin receptorFree leptin indexSOB-R concentrationsBaseline serum samplesLevels of leptinMultivariate linear regressionPhysical activityAssociated with obesityStatistically significant associationWomen's HealthPolyfluoroalkyl substancesWaist circumferenceKernel machine regressionWomen's backgroundInfluence obesityMidlife womenSmoking statusSOB-RMenopausal statusPerfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018
Ding N, Karvonen-Gutierrez C, Herman W, Calafat A, Mukherjee B, Park S. Perfluoroalkyl and polyfluoroalkyl substances and body size and composition trajectories in midlife women: the study of women’s health across the nation 1999–2018. International Journal Of Obesity 2021, 45: 1937-1948. PMID: 33986457, PMCID: PMC8384652, DOI: 10.1038/s41366-021-00848-9.Peer-Reviewed Original ResearchConceptsWaist circumferenceMidlife womenFat massLowest tertileAssociated with greater body sizeStudy of women's healthResultsAfter multivariable adjustmentAssociated with accelerated increaseTrajectories of weightAssociated with weightSubjects/MethodsThis studyWomen's HealthObesity riskFollow-upDual-energy X-ray absorptiometryLinear mixed modelsHighest tertileX-ray absorptiometryGreater body sizeMultivariable adjustmentBody fatEpidemiological evidenceNo significant resultsBody compositionAverage follow-up
2018
Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014
Wang X, Mukherjee B, Park S. Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003–2014. Environment International 2018, 121: 683-694. PMID: 30316184, PMCID: PMC6268112, DOI: 10.1016/j.envint.2018.09.035.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreAssociated with obesityHeavy metal mixturesHeavy metalsMetal mixturesAssociation of cumulative exposureCumulative exposureComplex survey designEffects of cumulative exposurePhysical activityObesity measuresAdaptive elastic-netChronic conditionsExposure to heavy metalsInteraction of heavy metalsWaist circumferenceTotal body fatNHANES cyclesU.S. adultsEpidemiological researchType 2 diabetes mellitusCorrelated heavy metalSmoking statusHigher BMISkinfold thickness
2014
Endogenous sex steroid hormones and glucose in a South‐Asian population without diabetes: the Metabolic Syndrome and Atherosclerosis in South‐Asians Living in America pilot study
Needham B, Kim C, Mukherjee B, Bagchi P, Stanczyk F, Kanaya A. Endogenous sex steroid hormones and glucose in a South‐Asian population without diabetes: the Metabolic Syndrome and Atherosclerosis in South‐Asians Living in America pilot study. Diabetic Medicine 2014, 32: 1193-1200. PMID: 25443798, PMCID: PMC4449322, DOI: 10.1111/dme.12642.Peer-Reviewed Original ResearchConceptsEndogenous sex steroid hormonesLevels of sex hormone-binding globulinAssociated with elevated fasting glucose levelsSex steroid hormonesSex hormone-binding globulinElevated fasting glucose levelsHormone-binding globulinSex steroid hormone levelsFasting glucose levelsSteroid hormone levelsGlucose levelsHepatic adipositySteroid hormonesWaist circumferenceMetabolic syndromeHigher levels of free testosteroneHormone levelsInsulin resistanceLevels of total testosteroneSouth Asian populationLevels of free testosteroneExogenous sex steroidsSouth AsiansAge-adjusted modelsAsian Indian origin
2010
HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study
Zhang A, Park S, Wright R, Weisskopf M, Mukherjee B, Nie H, Sparrow D, Hu H. HFE H63D Polymorphism as a Modifier of the Effect of Cumulative Lead Exposure on Pulse Pressure: The Normative Aging Study. Environmental Health Perspectives 2010, 118: 1261-1266. PMID: 20478760, PMCID: PMC2944087, DOI: 10.1289/ehp.1002251.Peer-Reviewed Original ResearchConceptsCumulative lead exposureHFE H63D polymorphismC282Y variantBone lead levelsAssociated with steeper increasesLinear mixed-effects regression modelsFamily history of hypertensionMixed-effects regression modelsDaily intake of calciumNormative Aging StudyPredictor of cardiovascular diseaseWaist circumferenceIntake of calciumHistory of hypertensionLead exposureH63D polymorphismAlcohol intakeRandom interceptFamily historyMarker of arterial stiffnessTotal caloriesAging StudySteeper increasesLead levelsCardiovascular disease