2022
Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort
Cathey A, Watkins D, Rosario Z, Vélez C, Mukherjee B, Alshawabkeh A, Cordero J, Meeker J. Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort. Environmental Health Perspectives 2022, 130: 037009. PMID: 35333099, PMCID: PMC8953418, DOI: 10.1289/ehp8990.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthFetal sexGestational agePregnancy outcomesBirth outcomesBayesian kernel machine regressionPhthalate metabolitesRisk of early deliveryAssociated with increased odds of PTBOdds of preterm birthPhthalate mixtureReduced gestational ageIndividual phthalate metabolitesMeasures of birth weightAssociated with increased riskPhthalate metabolite mixturesAdverse birth outcomesAssociated with increased oddsPuerto Rico TestsiteEnvironmental risk scoreEarly deliveryBirth weightPregnancy cohortLongitudinal pregnancy cohortMediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery
Cathey A, Aung M, Watkins D, Rosario Z, Vélez Vega C, Alshawabkeh A, Cordero J, Mukherjee B, Meeker J. Mediation by hormone concentrations on the associations between repeated measures of phthalate mixture exposure and timing of delivery. Journal Of Exposure Science & Environmental Epidemiology 2022, 32: 374-383. PMID: 34987188, PMCID: PMC9124667, DOI: 10.1038/s41370-021-00408-3.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthCorticotropin-releasing hormoneFetal sexMale fetusesEarly deliveryHormone concentrationsAssociated with earlier deliveryPhthalate exposurePhthalate mixtureReduced gestational ageTime of deliveryEnvironmental risk scoreGestational ageFemale fetusesUrinary phthalatesSex-specific analysesEndocrine-disrupting capabilitiesReleasing hormoneSerum hormonesFetusesRisk scoreSusceptible to endocrine disruptionBirth cohortHormone
2021
Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates
Aung M, Ashrap P, Watkins D, Mukherjee B, Rosario Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Maternal lipidomic signatures in relation to spontaneous preterm birth and large-for-gestational age neonates. Scientific Reports 2021, 11: 8115. PMID: 33854141, PMCID: PMC8046995, DOI: 10.1038/s41598-021-87472-9.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthBiomarkers of pregnancy outcomesGestational age neonatesPreterm birthAge neonatesPregnancy outcomesDegree of hydrocarbon chain saturationIncreased riskNeonatal anthropometric parametersAssociated with increased riskPlasmenyl phosphatidylethanolamineMaternal lipidomeWeeks gestationGestational ageLipidomic signatureAnthropometric parametersLiquid chromatography tandem mass spectrometryLipidomic profilesLipid metabolitesHydrocarbon chain saturationPlasma samplesBirthLogistic regressionHigh-performance liquid chromatography tandem mass spectrometryNeonatesPsychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes
Ashrap P, Aker A, Watkins D, Mukherjee B, Rosario-Pabón Z, Vélez-Vega C, Alshawabkeh A, Cordero J, Meeker J. Psychosocial status modifies the effect of maternal blood metal and metalloid concentrations on birth outcomes. Environment International 2021, 149: 106418. PMID: 33548848, PMCID: PMC7897320, DOI: 10.1016/j.envint.2021.106418.Peer-Reviewed Original ResearchConceptsAdverse birth outcomesPsychosocial statusBirth outcomesBody mass indexPsychosocial stressPreterm birthOdds ratioAssociated with adverse birth outcomesPre-pregnancy body mass indexSecond-hand smoke exposurePrenatal psychosocial stressPregnant womenBlood metalsClusters of womenEffects of psychosocial stressPuerto Rico TestsiteIncreased odds ratioSocial supportPerceived stressMaternal educationAdverse associationOverall preterm birthLow birth weightSpontaneous preterm birthCohort study
2019
Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers
Aung M, Yu Y, Ferguson K, Cantonwine D, Zeng L, McElrath T, Pennathur S, Mukherjee B, Meeker J. Prediction and associations of preterm birth and its subtypes with eicosanoid enzymatic pathways and inflammatory markers. Scientific Reports 2019, 9: 17049. PMID: 31745121, PMCID: PMC6863859, DOI: 10.1038/s41598-019-53448-z.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthMultiple logistic regressionCross-sectional study of pregnant womenAssociation of preterm birthCases of preterm birthStudy of pregnant womenOverall preterm birthPreterm birth casesPreterm birth outcomesCytochrome P450 metabolitesLogistic regressionOxidative stress markersAberrant placentationCross-sectional studyDelivered termCytochrome P450 productPredictive biomarkersPregnant womenPretermEicosanoid metabolitesImmune biomarkersLipoxygenase metabolitesBirth casesResolvin D1
2017
Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth
Johns L, Ferguson K, McElrath T, Mukherjee B, Seely E, Meeker J. Longitudinal Profiles of Thyroid Hormone Parameters in Pregnancy and Associations with Preterm Birth. PLOS ONE 2017, 12: e0169542. PMID: 28060899, PMCID: PMC5217954, DOI: 10.1371/journal.pone.0169542.Peer-Reviewed Original ResearchConceptsRisk of preterm birthPreterm birthNested case-control study of preterm birthThyroid hormonesSubclinical alterationsPregnant womenCase-control study of preterm birthThyroid diseaseOdds of preterm birthOngoing birth cohort studyNested case-control studyStudy of preterm birthAssociated with preterm birthBirth cohort studyTime pointsMultivariate logistic regression modelOverall preterm birthSpontaneous preterm birthWeeks of gestationClinical thyroid diseaseOvert thyroid diseaseThyroid hormone parametersMaternal thyroid hormone concentrationsMaternal thyroid hormonesLogistic regression models
2016
Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Ferguson K, Chen Y, VanderWeele T, McElrath T, Meeker J, Mukherjee B. Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environmental Health Perspectives 2016, 125: 488-494. PMID: 27352406, PMCID: PMC5332184, DOI: 10.1289/ehp282.Peer-Reviewed Original ResearchConceptsExposure-mediator interactionPreterm birthMaternal phthalate exposureNested case-control study of preterm birthCase-control study of preterm birthNested case-control studyPhthalate exposureStudy of preterm birthPhthalate metabolitesOxidative stressSpontaneous preterm birthLongitudinal measurementsMetabolites of di(2-ethylhexyl) phthalateOdds ratioRepeated measuresDi(2-ethylhexyl) phthalateMediation analysisRegression modelsOxidative stress biomarkersEstimated proportionPretermPregnancyInteraction termsBirthAssociation
2015
Urinary Bisphenol A Levels during Pregnancy and Risk of Preterm Birth
Cantonwine D, Ferguson K, Mukherjee B, McElrath T, Meeker J. Urinary Bisphenol A Levels during Pregnancy and Risk of Preterm Birth. Environmental Health Perspectives 2015, 123: 895-901. PMID: 25815860, PMCID: PMC4559950, DOI: 10.1289/ehp.1408126.Peer-Reviewed Original ResearchConceptsRisk of preterm birthPreterm birthBisphenol A exposurePreterm premature rupture of membranesClinical classificationClassification of preterm birthSubcategories of preterm birthPremature rupture of membranesBisphenol A levelsCases of preterm birthAssociated with preterm birthSpontaneous preterm laborPreterm premature ruptureRupture of membranesSpontaneous preterm birthIntrauterine growth restrictionNested case-control studyProspective birth cohort studyUrinary bisphenol ACase-control studyAssociated with increased oddsA levelsTertiary teaching hospitalBirth cohort studyDelivered preterm
2014
Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth
Ferguson K, McElrath T, Chen Y, Loch-Caruso R, Mukherjee B, Meeker J. Repeated measures of urinary oxidative stress biomarkers during pregnancy and preterm birth. American Journal Of Obstetrics And Gynecology 2014, 212: 208.e1-208.e8. PMID: 25111586, PMCID: PMC4312513, DOI: 10.1016/j.ajog.2014.08.007.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPreterm birthAssociated with increased odds of spontaneous preterm birthCases of spontaneous preterm birthOdds of spontaneous preterm birthPathways to preterm birthMechanisms of preterm birthNested case-control studyLevels of 8-isoprostaneOxidative stressUrinary biomarkers of oxidative stressConcentrations of 8-isoprostaneUrinary oxidative stress biomarkersLevels of 8-OHdGMaternal oxidative stressCase-control studyProspective birth cohortUrinary 8-OHdG concentrationsAssociated with increased oddsInvestigate oxidative stressDelivered pretermBiomarkers of oxidative stressPlacental originUrinary concentrations of 8-isoprostanePretermVariability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth
Ferguson K, McElrath T, Ko Y, Mukherjee B, Meeker J. Variability in urinary phthalate metabolite levels across pregnancy and sensitive windows of exposure for the risk of preterm birth. Environment International 2014, 70: 118-124. PMID: 24934852, PMCID: PMC4104181, DOI: 10.1016/j.envint.2014.05.016.Peer-Reviewed Original ResearchConceptsAdjusted odds ratiosUrinary phthalate metabolite levelsPreterm birthPhthalate metabolite levelsOdds ratioOdds of preterm birthAssociated with increased odds of preterm birthIncreased risk of delivering pretermCases of preterm birthWeeks of completed gestationRisk of delivering pretermAssociated with increased oddsMetabolite levelsPresentation of preeclampsiaSignificant public health problemSpontaneous preterm birthIntrauterine growth restrictionLongitudinal birth cohortPhthalate metabolite concentrationsPublic health problemBirth outcomesBirth cohortGrowth restrictionThird trimesterPregnant womenLongitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy
Ferguson K, McElrath T, Chen Y, Mukherjee B, Meeker J. Longitudinal Profiling of Inflammatory Cytokines and C‐reactive Protein during Uncomplicated and Preterm Pregnancy. American Journal Of Reproductive Immunology 2014, 72: 326-336. PMID: 24807462, PMCID: PMC4573571, DOI: 10.1111/aji.12265.Peer-Reviewed Original ResearchConceptsPreterm birthC-reactive proteinAssociated with increased oddsInflammation markersAssociated with increased odds of spontaneous preterm birthIL-10Associated with increased risk of preterm birthOdds of spontaneous preterm birthEtiology of preterm deliveryPredictors of preterm birthIL-6Risk of preterm birthPreterm premature ruptureSpontaneous preterm laborSpontaneous preterm birthIntrauterine growth restrictionNested case-control studyProfile of inflammatory cytokinesAssociated with increased riskCase-control studyPreterm laborPreterm pregnanciesPreterm deliveryGestational agePremature rupture