2022
DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors
Wang Y, Zhao W, Ammous F, Song Y, Du J, Shang L, Ratliff S, Moore K, Kelly K, Needham B, Roux A, Liu Y, Butler K, Kardia S, Mukherjee B, Zhou X, Smith J. DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors. Frontiers In Cardiovascular Medicine 2022, 9: 848768. PMID: 35665255, PMCID: PMC9162507, DOI: 10.3389/fcvm.2022.848768.Peer-Reviewed Original ResearchBody mass indexCardiovascular risk factorsNeighborhood socioeconomic disadvantageMulti-Ethnic Study of AtherosclerosisNeighborhood-level disadvantagePoor cardiovascular healthSocioeconomic statusSocioeconomic disadvantageRisk factorsCardiovascular healthAssociated with poor cardiovascular healthSocial disadvantageAdult socioeconomic statusBody mass index adjustmentAssociations of individual-HDL-CPrincipal components of ancestryGenetic principal componentsMeasures of obesityLow socioeconomic statusPopulation-based cohortMulti-Ethnic StudyStudy of AtherosclerosisHDL-C associationHigh-density lipoprotein cholesterol
2017
Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis
Smith J, Zhao W, Wang X, Ratliff S, Mukherjee B, Kardia S, Liu Y, Roux A, Needham B. Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis. Epigenetics 2017, 12: 662-673. PMID: 28678593, PMCID: PMC5687339, DOI: 10.1080/15592294.2017.1341026.Peer-Reviewed Original ResearchConceptsMulti-Ethnic Study of AtherosclerosisMulti-Ethnic StudyStudy of AtherosclerosisSocioeconomic disadvantageIndividual-level socioeconomic factorsEtiology of health disparitiesAssociated with poor health outcomesPopulation-based sample of US adultsSocioeconomic factorsNeighborhood conditionsNeighborhood socioeconomic disadvantageSample of US adultsNeighborhood social environmentHigher socioeconomic disadvantagePoor health outcomesIndividual socioeconomic factorsPopulation-based sampleDimensions of neighborhood contextHealth disparitiesInfluence methylation levelsHealth outcomesUS adultsSocial environmentDisadvantaged neighborhoodsNeighborhood characteristics