2013
Su2003 Cancer Spectrum, Parent of Origin Effect, and Anticipation in a Cohort of Lynch Syndrome Kindreds
Walshe M, Farrell M, Lyons T, Gogarty D, Dorman N, Hughes D, O'Brien L, Schmid J, Boonstra P, Mukherjee B, Gallagher D, Mac Mathuna P. Su2003 Cancer Spectrum, Parent of Origin Effect, and Anticipation in a Cohort of Lynch Syndrome Kindreds. Gastroenterology 2013, 144: s-529. DOI: 10.1016/s0016-5085(13)61965-4.Peer-Reviewed Original ResearchInvestigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds.
Farrell M, Hughes D, Schmid J, Boonstra P, Mukherjee B, Walshe M, Mac Mathuna P, Gallagher D. Investigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds. Journal Of Clinical Oncology 2013, 31: 431-431. DOI: 10.1200/jco.2013.31.4_suppl.431.Peer-Reviewed Original ResearchAffected parent-child pairsParent-of-origin effectsParent-child pairsInvestigate parent-of-origin effectsLynch syndrome familiesMMR mutation carriersLynch syndrome kindredGenetic anticipationHospital-based registryOffspring of affected mothersLS familiesLynch syndromePaired t-testRisk of diseaseSyndrome familiesMutation carriersInvestigate parentT-testDisease allelesAffected fatherStatistical significanceKindredMothersSeverity of diseaseFamily
2012
Investigating parent of origin effects (POE) and anticipation in Irish Lynch Syndrome kindreds.
Farrell M, Hughes D, Schmid J, Boonstra P, Mukherjee B, Walshe M, Mac Mathuna P, Gallagher D. Investigating parent of origin effects (POE) and anticipation in Irish Lynch Syndrome kindreds. Journal Of Clinical Oncology 2012, 30: e12031-e12031. DOI: 10.1200/jco.2012.30.15_suppl.e12031.Peer-Reviewed Original ResearchAffected parent-child pairsParent-of-origin effectsParent-child pairsInvestigate parent-of-origin effectsLynch syndrome familiesGermline MMR mutationsLynch syndrome kindredT-testMMR mutationsPaired t-testRisk of diseaseSyndrome familiesInvestigate parentGenetic anticipationParental ageP-valueGroup comparisonsDisease allelesOffspring ageAgeDynamic mutationSeverity of diseaseKindredIncreasing severityFamily