2022
Methods for large‐scale single mediator hypothesis testing: Possible choices and comparisons
Du J, Zhou X, Clark‐Boucher D, Hao W, Liu Y, Smith J, Mukherjee B. Methods for large‐scale single mediator hypothesis testing: Possible choices and comparisons. Genetic Epidemiology 2022, 47: 167-184. PMID: 36465006, PMCID: PMC10329872, DOI: 10.1002/gepi.22510.Peer-Reviewed Original ResearchConceptsNull hypothesisTest statisticsMediation hypothesis testingComposite null hypothesisHypothesis testingClasses of methodsFalse positive rateAlternative hypothesisSimulation studyHypothesis testing methodContinuous mediatorReference distributionSobel test statisticsContinuous outcomesExposure-mediator interactionMulti-Ethnic Study of AtherosclerosisDNA methylation sitesClassCRANMethylation sites
2009
Case–Control Studies of Gene–Environment Interaction: Bayesian Design and Analysis
Mukherjee B, Ahn J, Gruber S, Ghosh M, Chatterjee N. Case–Control Studies of Gene–Environment Interaction: Bayesian Design and Analysis. Biometrics 2009, 66: 934-948. PMID: 19930190, PMCID: PMC3103064, DOI: 10.1111/j.1541-0420.2009.01357.x.Peer-Reviewed Original ResearchConceptsGene-environment interactionsCase-control study of colorectal cancerStudy of gene-environment interactionsStudy of colorectal cancerGene-environment independenceRed meat consumptionBayesian designCase-control studyBayesian approachSample size determination criteriaCase-controlEpidemiological studiesColorectal cancerFrequentist counterpartsNatural wayMeat consumptionAnalyze current dataHypothesis testingDetermination criteriaSmokingEpidemiological exposureAnalysis strategyStudy