DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors
Wang Y, Zhao W, Ammous F, Song Y, Du J, Shang L, Ratliff S, Moore K, Kelly K, Needham B, Roux A, Liu Y, Butler K, Kardia S, Mukherjee B, Zhou X, Smith J. DNA Methylation Mediates the Association Between Individual and Neighborhood Social Disadvantage and Cardiovascular Risk Factors. Frontiers In Cardiovascular Medicine 2022, 9: 848768. PMID: 35665255, PMCID: PMC9162507, DOI: 10.3389/fcvm.2022.848768.Peer-Reviewed Original ResearchBody mass indexCardiovascular risk factorsNeighborhood socioeconomic disadvantageMulti-Ethnic Study of AtherosclerosisNeighborhood-level disadvantagePoor cardiovascular healthSocioeconomic statusSocioeconomic disadvantageRisk factorsCardiovascular healthAssociated with poor cardiovascular healthSocial disadvantageAdult socioeconomic statusBody mass index adjustmentAssociations of individual-HDL-CPrincipal components of ancestryGenetic principal componentsMeasures of obesityLow socioeconomic statusPopulation-based cohortMulti-Ethnic StudyStudy of AtherosclerosisHDL-C associationHigh-density lipoprotein cholesterolMetals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States
Wang X, Karvonen-Gutierrez C, Herman W, Mukherjee B, Park S. Metals and risk of incident metabolic syndrome in a prospective cohort of midlife women in the United States. Environmental Research 2022, 210: 112976. PMID: 35202625, PMCID: PMC9869389, DOI: 10.1016/j.envres.2022.112976.Peer-Reviewed Original ResearchConceptsEnvironmental risk scoreCohort of midlife womenIncident MetSMidlife womenHazard ratioRisk of incident MetSRisk of incident metabolic syndromeProspective cohortStudy of Women's HealthFree of MetSRisk of cardiometabolic diseasesIncident metabolic syndromeMetabolic syndromeImpaired fasting glucoseCox proportional hazards modelsHigh-density lipoprotein cholesterolHigh blood pressureMetS incidenceWomen's HealthProportional hazards modelAbdominal obesityNation Multi-Pollutant StudyDevelopment of metabolic syndromeCardiometabolic diseasesHigh triglycerides