2017
Meta‐analysis of gene‐environment interaction exploiting gene‐environment independence across multiple case‐control studies
Estes J, Rice J, Li S, Stringham H, Boehnke M, Mukherjee B. Meta‐analysis of gene‐environment interaction exploiting gene‐environment independence across multiple case‐control studies. Statistics In Medicine 2017, 36: 3895-3909. PMID: 28744888, PMCID: PMC5624850, DOI: 10.1002/sim.7398.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlpha-Ketoglutarate-Dependent Dioxygenase FTOBayes TheoremBiasBiometryBody Mass IndexCase-Control StudiesComputer SimulationDiabetes Mellitus, Type 2Gene-Environment InteractionHumansLogistic ModelsMeta-Analysis as TopicModels, GeneticModels, StatisticalPolymorphism, Single NucleotideRetrospective StudiesConceptsGene-environment independenceGene-environmentEmpirical Bayes estimatorsGene-environment interactionsCase-control studyMeta-analysis settingBayes estimatorsRetrospective likelihood frameworkShrinkage estimatorsMeta-analysisTesting gene-environment interactionsCombination of estimatesFactors body mass indexSimulation studyBody mass indexUnconstrained modelLikelihood frameworkInverse varianceMeta-analysis frameworkFTO geneMass indexGenetic markersEstimationStandard alternativeChatterjee
2013
Bayesian semiparametric analysis for two-phase studies of gene-environment interaction
Ahn J, Mukherjee B, Gruber S, Ghosh M. Bayesian semiparametric analysis for two-phase studies of gene-environment interaction. The Annals Of Applied Statistics 2013, 7: 543-569. PMID: 24587840, PMCID: PMC3935248, DOI: 10.1214/12-aoas599.Peer-Reviewed Original ResearchBayesian variable selection algorithmTwo-phase sampling designGene-environment independencePseudo-likelihood methodJoint effects of genotypeGene-environment interactionsHigh-dimensional modelsWeighted likelihoodCase-control study of colorectal cancerJoint distributionHierarchical priorsSemiparametric analysisRetrospective likelihoodGenetic markersCovariate informationLikelihood methodSimulation studyStudy of gene-environment interactionsStudy of colorectal cancerVariable selection algorithmBayesian approachPhase I dataSub-sample of casesBayesian methodsBayesian analysis
2009
Shrinkage estimation for robust and efficient screening of single‐SNP association from case‐control genome‐wide association studies
Luo S, Mukherjee B, Chen J, Chatterjee N. Shrinkage estimation for robust and efficient screening of single‐SNP association from case‐control genome‐wide association studies. Genetic Epidemiology 2009, 33: 740-750. PMID: 19434716, PMCID: PMC3103068, DOI: 10.1002/gepi.20428.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesComputational BiologyComputer SimulationData Interpretation, StatisticalFalse Positive ReactionsGenetic MarkersGenomeGenome, HumanGenome-Wide Association StudyGenotypeHumansLikelihood FunctionsModels, StatisticalPolymorphism, Single NucleotideReproducibility of ResultsConceptsHardy-Weinberg equilibriumAssociation TestPopulation-based case-control designGenome-wide association scanGenome-wide association studiesSingle-SNP associationsCase-control designCase-control studyAssociation scansAssociation studiesGenetic markersSusceptibility SNPsRecessive effectUnderlying populationAssociationFalse-positive resultsEfficient screeningSNPsRare diseaseShrinkage estimatorsSimulation studyStudyTestTwo-degrees-of-freedomPopulation