2024
Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts
Suthar H, Manea T, Pak D, Woodbury M, Eick S, Cathey A, Watkins D, Strakovsky R, Ryva B, Pennathur S, Zeng L, Weller D, Park J, Smith S, DeMicco E, Padula A, Fry R, Mukherjee B, Aguiar A, Geiger S, Ng S, Huerta-Montanez G, Vélez-Vega C, Rosario Z, Cordero J, Zimmerman E, Woodruff T, Morello-Frosch R, Schantz S, Meeker J, Alshawabkeh A, Aung M, Outcomes O. Cross-Sectional Associations between Prenatal Per- and Poly-Fluoroalkyl Substances and Bioactive Lipids in Three Environmental Influences on Child Health Outcomes (ECHO) Cohorts. Environmental Science And Technology 2024, 58: 8264-8277. PMID: 38691655, PMCID: PMC11097396, DOI: 10.1021/acs.est.4c00094.Peer-Reviewed Original ResearchConceptsPFAS mixtureLinear mixed modelsBioactive lipidsChild health outcomesCross-sectional associationsPrenatal PFAS exposureBioactive lipid levelsPoly-fluoroalkyl substancesQuantile g-computationMixed modelsGestational outcomesHealth outcomesPregnancy outcomesPregnant womenCombined cohortG-computationCohort analysisProgram cohortQuartile increaseLipid levelsCohortPositive associationMeta-analysisEnvironmental influencesPFAS exposure
2023
The role of exposure to per- and polyfluoroalkyl substances in racial/ethnic disparities in hypertension: Results from the study of Women's health across the nation
Ding N, Karvonen-Gutierrez C, Zota A, Mukherjee B, Harlow S, Park S. The role of exposure to per- and polyfluoroalkyl substances in racial/ethnic disparities in hypertension: Results from the study of Women's health across the nation. Environmental Research 2023, 227: 115813. PMID: 37004857, PMCID: PMC10227830, DOI: 10.1016/j.envres.2023.115813.Peer-Reviewed Original ResearchStudy of Women's HealthRacial/ethnic disparitiesWomen's HealthIncident hypertensionMidlife womenSerum PFAS concentrationsHypertension onsetModifiable risk factorsAnnual follow-up visitsCausal mediation analysisContribution of environmental pollutionPublic health problemAssociated with hypertensionRacial/ethnic differencesPFAS exposureBlack participantsWhite participantsFollow-up visitG-computationQuantile-based g-computationWhite womenHealth problemsPFAS concentrationsExposure to per-Disparities
2022
Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation
Ding N, Karvonen-Gutierrez C, Mukherjee B, Calafat A, Harlow S, Park S. Per- and Polyfluoroalkyl Substances and Incident Hypertension in Multi-Racial/Ethnic Women: The Study of Women's Health Across the Nation. Hypertension 2022, 79: 1876-1886. PMID: 35695012, PMCID: PMC9308661, DOI: 10.1161/hypertensionaha.121.18809.Peer-Reviewed Original ResearchConceptsHazard ratioIncident hypertensionLowest tertileHighest tertileStudy of Women's HealthFree of hypertensionCalculate hazard ratiosAnnual follow-up visitsCardiovascular disease riskCox proportional hazards modelsQuantile g-computationWomen's cardiovascular disease riskWomen's HealthNo significant associationProportional hazards modelMidlife womenFollow-up visitG-computationDisease riskBlood pressure controlSerum concentrationsSignificant associationPositive associationHazards modelTertilePer- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN)
Park S, Wang X, Ding N, Karvonen-Gutierrez C, Calafat A, Herman W, Mukherjee B, Harlow S. Per- and polyfluoroalkyl substances and incident diabetes in midlife women: the Study of Women’s Health Across the Nation (SWAN). Diabetologia 2022, 65: 1157-1168. PMID: 35399113, PMCID: PMC9177697, DOI: 10.1007/s00125-022-05695-5.Peer-Reviewed Original ResearchConceptsStudy of Women's HealthIncident diabetesWomen's HealthPolyfluoroalkyl substancesDiabetes riskMidlife womenSelf-reported diabetesTotal energy intakeProspective cohort studyIncreased diabetes riskCox proportional hazards modelsPhysical activityGlucose-lowering medicationsProportional hazards modelResultsAfter adjustmentNation Multi-Pollutant StudyBottom tertileSmoking statusHighest tertileAlcohol consumptionDiabetes-free womenFollow-up visitG-computationQuantile-based g-computationCohort study
2021
Urinary concentrations of phenols and parabens and incident diabetes in midlife women
Lee S, Karvonen-Gutierrez C, Mukherjee B, Herman W, Harlow S, Park S. Urinary concentrations of phenols and parabens and incident diabetes in midlife women. Environmental Epidemiology 2021, 5: e171. PMID: 34934892, PMCID: PMC8683147, DOI: 10.1097/ee9.0000000000000171.Peer-Reviewed Original ResearchIncident diabetesHazard ratioAssociated with incident diabetesStudy of Women's HealthMid-life womenAdjusted hazard ratiosAssociation of incident diabetesProspective cohort studyWomen's HealthNo significant associationWomen's backgroundConcentration of phenolJoint effectsExposure variablesG-computationQuantile-based g-computationWithin-person variabilityBenzophenone-3Cohort studyDiabetes-freeBisphenol ANonlinear associationSignificant associationJoint effect of mixturesConcentrations of bisphenol A