2022
Methods for large‐scale single mediator hypothesis testing: Possible choices and comparisons
Du J, Zhou X, Clark‐Boucher D, Hao W, Liu Y, Smith J, Mukherjee B. Methods for large‐scale single mediator hypothesis testing: Possible choices and comparisons. Genetic Epidemiology 2022, 47: 167-184. PMID: 36465006, PMCID: PMC10329872, DOI: 10.1002/gepi.22510.Peer-Reviewed Original ResearchConceptsNull hypothesisTest statisticsMediation hypothesis testingComposite null hypothesisHypothesis testingClasses of methodsFalse positive rateAlternative hypothesisSimulation studyHypothesis testing methodContinuous mediatorReference distributionSobel test statisticsContinuous outcomesExposure-mediator interactionMulti-Ethnic Study of AtherosclerosisDNA methylation sitesClassCRANMethylation sites
2016
Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy
Ferguson K, Chen Y, VanderWeele T, McElrath T, Meeker J, Mukherjee B. Mediation of the Relationship between Maternal Phthalate Exposure and Preterm Birth by Oxidative Stress with Repeated Measurements across Pregnancy. Environmental Health Perspectives 2016, 125: 488-494. PMID: 27352406, PMCID: PMC5332184, DOI: 10.1289/ehp282.Peer-Reviewed Original ResearchConceptsExposure-mediator interactionPreterm birthMaternal phthalate exposureNested case-control study of preterm birthCase-control study of preterm birthNested case-control studyPhthalate exposureStudy of preterm birthPhthalate metabolitesOxidative stressSpontaneous preterm birthLongitudinal measurementsMetabolites of di(2-ethylhexyl) phthalateOdds ratioRepeated measuresDi(2-ethylhexyl) phthalateMediation analysisRegression modelsOxidative stress biomarkersEstimated proportionPretermPregnancyInteraction termsBirthAssociationMediation Formula for a Binary Outcome and a Time-Varying Exposure and Mediator, Accounting for Possible Exposure-Mediator Interaction
Chen Y, Mukherjee B, Ferguson K, Meeker J, VanderWeele T. Mediation Formula for a Binary Outcome and a Time-Varying Exposure and Mediator, Accounting for Possible Exposure-Mediator Interaction. American Journal Of Epidemiology 2016, 184: 157-159. PMID: 27325886, PMCID: PMC4945703, DOI: 10.1093/aje/kww045.Peer-Reviewed Original Research