Investigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds.
Farrell M, Hughes D, Schmid J, Boonstra P, Mukherjee B, Walshe M, Mac Mathuna P, Green A, Gallagher D. Investigating parent of origin effects (POE) and anticipation in Irish Lynch syndrome kindreds. Journal Of Clinical Oncology 2013, 31: 1542-1542. DOI: 10.1200/jco.2013.31.15_suppl.1542.Peer-Reviewed Original ResearchAffected parent-child pairsParent-of-origin effectsParent-child pairsLS familiesLynch syndromePaired t-testInvestigate parent-of-origin effectsCancer genetics centresLynch syndrome kindredHospital-based registryT-testOffspring of affected mothersRisk of diseaseGenetic centresEvidence of anticipationInvestigate parentGenetic anticipationDisease allelesAffected fatherStatistical significanceEarly onsetMothersSeverity of diseaseFamilyCancer