Featured Publications
Set-Based Tests for the Gene–Environment Interaction in Longitudinal Studies
He Z, Zhang M, Lee S, Smith J, Kardia S, Roux V, Mukherjee B. Set-Based Tests for the Gene–Environment Interaction in Longitudinal Studies. Journal Of The American Statistical Association 2017, 112: 966-978. PMID: 29780190, PMCID: PMC5954413, DOI: 10.1080/01621459.2016.1252266.Peer-Reviewed Original ResearchGene-environment interactionsMulti-Ethnic Study of AtherosclerosisSet-based testMeasures of neighborhood environmentMarginal genetic associationsEnvironmental exposuresMulti-Ethnic StudyStudy of AtherosclerosisNeighborhood environmentMeasurement of blood pressureGene-environmentMain-effects modelScore type testsMethod of sievesLongitudinal measures of blood pressureRobust to misspecificationGenetic associationGenetic variantsLongitudinal studyMain effectStudy periodEffects modelContinuous environmental exposurePotential biasIndependent conditions
2011
Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case Study in Lynch Syndrome
Boonstra P, Mukherjee B, Taylor J, Nilbert M, Moreno V, Gruber S. Bayesian Modeling for Genetic Anticipation in Presence of Mutational Heterogeneity: A Case Study in Lynch Syndrome. Biometrics 2011, 67: 1627-1637. PMID: 21627626, PMCID: PMC3176998, DOI: 10.1111/j.1541-0420.2011.01607.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAgedAnticipation, GeneticBayes TheoremChildChild, PreschoolColorectal Neoplasms, Hereditary NonpolyposisComputer SimulationDenmarkFemaleHumansInfantInfant, NewbornMaleMiddle AgedModels, GeneticModels, StatisticalMutationPolymorphism, Single NucleotidePrevalenceRisk AssessmentRisk FactorsYoung AdultConceptsLynch syndromeBirth cohortGenetic anticipationHereditary nonpolyposis colorectal cancerCancer registry dataNonpolyposis colorectal cancerDanish Cancer RegisterGenetic counseling clinicAge-specific incidenceHigh-risk familiesRandom-effects modelCancer RegisterRegistry dataCounseling clinicMismatch repairRandom effectsSecular trendsMedical practiceColorectal cancerSurvival analysis methodsEffects modelConfounding effectsLynchFlexible random effects modelModel fit diagnostics