2024
LDER-GE estimates phenotypic variance component of gene–environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information
Dong Z, Jiang W, Li H, DeWan A, Zhao H. LDER-GE estimates phenotypic variance component of gene–environment interactions in human complex traits accurately with GE interaction summary statistics and full LD information. Briefings In Bioinformatics 2024, 25: bbae335. PMID: 38980374, PMCID: PMC11232466, DOI: 10.1093/bib/bbae335.Peer-Reviewed Original ResearchConceptsHuman complex traitsComplex traitsGene-environment interactionsGene-environmentLinkage disequilibriumPhenotypic variance componentsPhenotypic varianceProportion of phenotypic varianceSummary statisticsEuropean ancestry subjectsUK Biobank dataAssociation summary statisticsComplete linkage disequilibriumControlled type I error ratesLD informationLD matrixVariance componentsBiobank dataType I error rateEuropean ancestrySample size increaseGenetic effectsTraitsE-I pairsSimulation studyA Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections
Flatby H, Ravi A, Liyanarachi K, Afset J, Rasheed H, Brumpton B, Hveem K, Åsvold B, DeWan A, Solligård E, Damås J, Rogne T. A Genome-wide Association Study of Susceptibility to Upper Urinary Tract Infections. The Journal Of Infectious Diseases 2024, jiae231. PMID: 38713594, DOI: 10.1093/infdis/jiae231.Peer-Reviewed Original ResearchGenome-wide association studiesMichigan Genomics InitiativeAssociation studiesUpper UTIMendelian randomizationMR analysisUpper urinary tract infectionRisk factorsPotential causal risk factorsCardiometabolic risk factorsModifiable risk factorsSex-stratified analysesCausal risk factorUrinary tract infectionGenome-wideFemale-only analysisGenetic lociPotential causal relationshipGenome InitiativeHealth StudyUK BiobankHLA-DQA2LociTract infectionsSmoking scoreA mediation analysis framework based on variance component to remove genetic confounding effect
Dong Z, Zhao H, DeWan A. A mediation analysis framework based on variance component to remove genetic confounding effect. Journal Of Human Genetics 2024, 69: 301-309. PMID: 38528049, DOI: 10.1038/s10038-024-01232-x.Peer-Reviewed Original ResearchMediation analysis frameworkSingle nucleotide polymorphismsMediation analysisPleiotropic single nucleotide polymorphismsUK Biobank dataConfounding effectsTrait pairsBiobank dataIndividual-levelEpidemiological studiesCausal effectsGenetic signalsEstimated effectsLinear regressionNucleotide polymorphismsStandard errorData analysisGenetic correlationsPhenotypeIndirect effectsPleiotropyVariance componentsOutcomesRegression
2023
Systematic review and meta-analysis of the genetics of peripheral arterial disease
Ochoa Chaar C, Kim T, Alameddine D, DeWan A, Guzman R, Dardik A, Grossetta Nardini H, Wallach J, Kullo I, Murray M. Systematic review and meta-analysis of the genetics of peripheral arterial disease. JVS Vascular Science 2023, 5: 100133. PMID: 38314202, PMCID: PMC10832467, DOI: 10.1016/j.jvssci.2023.100133.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsGenome-wide association studiesDNA variantsWide association studyRecent genome-wide association studiesSmall candidate gene studiesCandidate gene studiesGWAS studiesCandidate genesAssociation studiesGene studiesGenetic researchGeneticsOnly variantVariantsHepatic lipaseGenesProgressionSignificant variationDigital biobanks are underutilized in dermatology and create opportunities to reduce the burden of skin disease
Jumonville G, Hong D, Khan A, DeWan A, Leal S, Weng C, Petukhova L. Digital biobanks are underutilized in dermatology and create opportunities to reduce the burden of skin disease. British Journal Of Dermatology 2023, 190: 566-568. PMID: 37936310, PMCID: PMC10941321, DOI: 10.1093/bjd/ljad439.Peer-Reviewed Original ResearchConceptsBurden of skin diseaseGenetic architectureDiscover genesGenetic dataGene-environment interactionsClinical areasBiobank dataHealth dataMedical careDisease mechanismsGlobal burdenDisease relationshipsMedical interventionsDrug repurposingPharmacogenetic relationshipBiobankSkin diseasesGlobal burden of skin diseaseGenesKnowledge promisesAdverse eventsCareDermatologyHealthDiseaseMendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia
Rogne T, DeWan A, Metayer C, Wiemels J, Ma X. Mendelian randomization study of birthweight, gestational age, and risk of childhood acute lymphoblastic leukemia. American Journal Of Obstetrics & Gynecology MFM 2023, 5: 101058. PMID: 37330008, DOI: 10.1016/j.ajogmf.2023.101058.Peer-Reviewed Original ResearchVariants in JAZF1 are associated with asthma, type 2 diabetes, and height in the United Kingdom biobank population
DeWan A, Cahill M, Cornejo-Sanchez D, Li Y, Dong Z, Fabiha T, Sun H, Wang G, Leal S. Variants in JAZF1 are associated with asthma, type 2 diabetes, and height in the United Kingdom biobank population. Frontiers In Genetics 2023, 14: 1129389. PMID: 37377600, PMCID: PMC10291233, DOI: 10.3389/fgene.2023.1129389.Peer-Reviewed Original ResearchComplex traitsGenome-wide significant variantsFine-mapping analysisGenomic regionsMajor genetic componentAssociation analysisSusceptibility variantsGenetic componentSignificant variantsGenetic variantsSuggestive associationTraitsPhenotypeVariantsBiobank dataGenesNon-overlapping regionsRegionJAZF1Univariate association analysisType 2 diabetesComparison of multiple imputation and other methods for the analysis of imputed genotypes
Auer P, Wang G, Li G, DeWan A, Leal S. Comparison of multiple imputation and other methods for the analysis of imputed genotypes. BMC Genomics 2023, 24: 303. PMID: 37277705, PMCID: PMC10242917, DOI: 10.1186/s12864-023-09415-0.Peer-Reviewed Original ResearchComparative Analysis of Reinterventions After Lower Extremity Revascularization Between the Sexes
Terrazos-Moreno R, Satam K, Zhuo H, Alameddine D, DeWan A, Mena-Hurtado C, Guzman R, Chaar C. Comparative Analysis of Reinterventions After Lower Extremity Revascularization Between the Sexes. Journal Of Vascular Surgery 2023, 77: e47-e49. DOI: 10.1016/j.jvs.2023.03.045.Peer-Reviewed Original ResearchSaddlepoint approximations to score test statistics in logistic regression for analyzing genome‐wide association studies
Johnsen P, Bakke Ø, Bjørnland T, DeWan A, Langaas M. Saddlepoint approximations to score test statistics in logistic regression for analyzing genome‐wide association studies. Statistics In Medicine 2023, 42: 2746-2759. PMID: 37094813, DOI: 10.1002/sim.9746.Peer-Reviewed Original ResearchInferring feature importance with uncertainties with application to large genotype data
Johnsen P, Strümke I, Langaas M, DeWan A, Riemer-Sørensen S. Inferring feature importance with uncertainties with application to large genotype data. PLOS Computational Biology 2023, 19: e1010963. PMID: 36917581, PMCID: PMC10038287, DOI: 10.1371/journal.pcbi.1010963.Peer-Reviewed Original ResearchDyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study
Hosier H, Lipkind H, Rasheed H, DeWan A, Rogne T. Dyslipidemia and Risk of Preeclampsia: A Multiancestry Mendelian Randomization Study. Hypertension 2023, 80: 1067-1076. PMID: 36883459, DOI: 10.1161/hypertensionaha.122.20426.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaProtective effectCholesteryl Ester Transfer Protein InhibitionLack of effectMendelian randomization studyMendelian randomization analysisMaternal morbidityElevated HDLLeading causeLipid levelsObservational studyPreeclampsiaLipid measurementsReduced riskAncestry groupsPharmacological targetsRandomization studyHDLLDLRandomization analysisSingle nucleotide polymorphismsNew targetsDyslipidemiaRiskProtein inhibitionEarly-Onset Colorectal Cancer Somatic Gene Mutations by Population Subgroups.
Shen X, DeWan A, Johnson C. Early-Onset Colorectal Cancer Somatic Gene Mutations by Population Subgroups. Cancer Discovery 2023, 13: 530-531. PMID: 36855917, DOI: 10.1158/2159-8290.cd-22-1464.Peer-Reviewed Original ResearchThe genetic contribution of the X chromosome in age-related hearing loss
Naderi E, Cornejo-Sanchez D, Li G, Schrauwen I, Wang G, Dewan A, Leal S. The genetic contribution of the X chromosome in age-related hearing loss. Frontiers In Genetics 2023, 14: 1106328. PMID: 36896235, PMCID: PMC9988903, DOI: 10.3389/fgene.2023.1106328.Peer-Reviewed Original ResearchX chromosomeChromosome XGenome-wide significance levelMRNA expression analysisExpression analysisChromosomesAssociation analysisGenetic variantsCommon sensory impairmentGenetic contributionAnalysis of malesAge-related hearing lossHair cellsInner ear tissuesInner hair cellsUK BiobankARHLVariantsHuman inner ear tissueEar tissueGenesLociHeritabilitySex-stratified analysesCellsRare-variant association analysis reveals known and new age-related hearing loss genes
Cornejo-Sanchez D, Li G, Fabiha T, Wang R, Acharya A, Everard J, Kadlubowska M, Huang Y, Schrauwen I, Wang G, DeWan A, Leal S. Rare-variant association analysis reveals known and new age-related hearing loss genes. European Journal Of Human Genetics 2023, 31: 638-647. PMID: 36788145, PMCID: PMC10250305, DOI: 10.1038/s41431-023-01302-2.Peer-Reviewed Original ResearchType 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood
Dong Z, Myklebust Å, Johnsen I, Jartti T, Døllner H, Risnes K, DeWan A. Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood. Frontiers In Immunology 2023, 13: 1054119. PMID: 36685501, PMCID: PMC9852873, DOI: 10.3389/fimmu.2022.1054119.Peer-Reviewed Original ResearchConceptsAllergic asthmaViral bronchiolitisRisk factorsViral infectionDetailed lung function testsAllergic asthma developmentHistory of bronchiolitisHuman Metapneumovirus InfectionVariable airway obstructionAsthma risk factorsType 2 cytokinesDevelopment of asthmaLung function testsGenetic variantsCohort of childrenSpecific viral infectionsEarly childhoodType 2 cytokine genesSchool agePotential candidate targetAirway obstructionMetapneumovirus infectionMedian ageAsthma developmentFunction testsDyslipidemia and risk of hypertensive disorders of pregnancy: a multi-ancestry Mendelian Randomization study
Hosier H, Lipkind H, DeWan A, Rogne T. Dyslipidemia and risk of hypertensive disorders of pregnancy: a multi-ancestry Mendelian Randomization study. American Journal Of Obstetrics And Gynecology 2023, 228: s141-s142. DOI: 10.1016/j.ajog.2022.11.280.Peer-Reviewed Original Research
2022
Circulating miRNAs in the first trimester and pregnancy complications: a systematic review
Subramanian A, Weiss D, Nyhan K, Dewan A, Jukic A. Circulating miRNAs in the first trimester and pregnancy complications: a systematic review. Epigenetics 2022, 18: 2152615. PMID: 36503407, PMCID: PMC9980650, DOI: 10.1080/15592294.2022.2152615.Peer-Reviewed Original ResearchConceptsPregnancy complicationsSystematic reviewFirst trimesterMiR-520hPlacental originMiR-518bFuture pregnancy complicationsMost pregnancy complicationsFirst-trimester serumFirst trimester biomarkersPotential early biomarkersGestational hypertensionPreterm birthPlacental pathologyEarly biomarkersComplicationsEarly placentationPotential biomarkersPlasma miRNAsPreeclampsiaMiR-125bEarly detectionBiomarkersMiR-365aMost evidenceEscalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization
Kim T, DeWan A, Murray M, Wang H, Mani A, Mena-Hurtado C, Guzman R, Chaar C. Escalation of Antithrombotic Therapy in Patients With Premature Peripheral Artery Disease Undergoing Lower Extremity Revascularization. Journal Of Vascular Surgery 2022, 75: e281. DOI: 10.1016/j.jvs.2022.03.640.Peer-Reviewed Original ResearchLower Extremity Revascularization Among Patients With Premature Peripheral Artery Disease Compared To Patients At The Common Age Of Presentation In The Vascular Quality Initiative
Kim T, Loh S, Dewan A, Murray M, Mojibian H, Mani A, Mena-Hurtado C, Chaar C. Lower Extremity Revascularization Among Patients With Premature Peripheral Artery Disease Compared To Patients At The Common Age Of Presentation In The Vascular Quality Initiative. Annals Of Vascular Surgery 2022, 79: 400-401. DOI: 10.1016/j.avsg.2021.12.049.Peer-Reviewed Original ResearchMajor adverse limb eventsLower extremity revascularizationPeripheral artery diseaseCommon ageExtremity revascularizationArtery diseaseAdverse limb eventsDe novo diseaseOutcomes of patientsVascular Quality InitiativeInsulin-dependent diabetesSevere disease burdenNovo diseaseTASC classificationConclusions PatientsPatient agePatients 60Poor outcomeDisease burdenSevere diseaseLimb eventsPatientsLogistic regressionOne-yearDisease