2022
EGFR pathway targeting drugs in head and neck cancer in the era of immunotherapy
Kang J, Ko A, Kil S, Mallen-St Clair J, Shin D, Wang M, Srivatsan E. EGFR pathway targeting drugs in head and neck cancer in the era of immunotherapy. Biochimica Et Biophysica Acta (BBA) - Reviews On Cancer 2022, 1878: 188827. PMID: 36309124, DOI: 10.1016/j.bbcan.2022.188827.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorReceptor tyrosine kinasesEGFR mAbsNeck cancerEGFR monoclonal antibody cetuximabEra of immunotherapyTreatment of HNCMonoclonal antibody cetuximabTyrosine kinase inhibitorsEGFR variant IIIGrowth factor receptorMetastatic HNCEGFR resistanceImmune cellsClinical trialsOnly FDAAntibody cetuximabGrowth factor ligandsSmall molecule inhibitorsVariant IIIMTOR pathwayCombinatorial treatmentEGFR overexpressionTumor microenvironmentImmunotherapy
2021
Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study
Ticona J, Nery N, Ladines-Lim JB, Gambrah C, Sacramento G, de Paula Freitas B, Bouzon J, Oliveira-Filho J, Borja A, Adhikarla H, Montoya M, Chin A, Wunder EA, Ballalai V, Vieira C, Belfort R, Almeida A, Reis MG, Harris E, Ko AI, Costa F. Developmental outcomes in children exposed to Zika virus in utero from a Brazilian urban slum cohort study. PLOS Neglected Tropical Diseases 2021, 15: e0009162. PMID: 33544730, PMCID: PMC7891708, DOI: 10.1371/journal.pntd.0009162.Peer-Reviewed Original ResearchConceptsPopulation attributable fractionZIKV exposureMonths of ageMild cognitive delayZika virus exposureZIKV-exposed childrenPopulation-based cohortCognitive delayDevelopmental alterationsMonoclonal antibody blockadeMonths of lifeGross birth defectsAppropriate control groupsProspective serosurveyCohort studyNeurodevelopmental outcomesAntibody blockadeNeurodevelopmental evaluationVirus exposureAttributable fractionBehavioral abnormalitiesControl groupRest of womenZika virusCohort
1987
Characterization of protective and non-protective surface membrane carbohydrate epitopes of Schistosoma mansoni
Ko A, Harn D. Characterization of protective and non-protective surface membrane carbohydrate epitopes of Schistosoma mansoni. Memórias Do Instituto Oswaldo Cruz 1987, 82: 115-119. PMID: 2474123, DOI: 10.1590/s0074-02761987000800019.Peer-Reviewed Original ResearchConceptsKeyhole limpet hemocyaninNon-protective antibodiesMonoclonal antibodiesCarbohydrate epitopesProtective monoclonal antibodyEpitope mapping studiesDifferent carbohydrate epitopesLimpet hemocyaninSchistosomula antigensDifferent epitopesSchistosoma mansoniAntibodiesAntigenEpitopesImmunoprecipitation studiesBinding assaysInhibition studiesVaccineMansoni