2021
Effect of Sewerage on the Contamination of Soil with Pathogenic Leptospira in Urban Slums
Casanovas-Massana A, Souza F, Curry M, de Oliveira D, de Oliveira AS, Eyre MT, Santiago D, Santos M, Serra RMR, Lopes E, Xavier BI, Diggle PJ, Wunder EA, Reis MG, Ko AI, Costa F. Effect of Sewerage on the Contamination of Soil with Pathogenic Leptospira in Urban Slums. Environmental Science And Technology 2021, 55: 15882-15890. PMID: 34767339, PMCID: PMC9302045, DOI: 10.1021/acs.est.1c04916.Peer-Reviewed Original ResearchPoverty, sanitation, and Leptospira transmission pathways in residents from four Brazilian slums
Khalil H, Santana R, de Oliveira D, Palma F, Lustosa R, Eyre MT, Carvalho-Pereira T, Reis MG, Ko AI, Diggle PJ, Lopez Y, Begon M, Costa F. Poverty, sanitation, and Leptospira transmission pathways in residents from four Brazilian slums. PLOS Neglected Tropical Diseases 2021, 15: e0009256. PMID: 33788864, PMCID: PMC8041187, DOI: 10.1371/journal.pntd.0009256.Peer-Reviewed Original ResearchA live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus
Wunder EA, Adhikarla H, Hamond C, Bonner K, Liang L, Rodrigues CB, Bisht V, Nally JE, Alt DP, Reis MG, Diggle PJ, Felgner PL, Ko A. A live attenuated-vaccine model confers cross-protective immunity against different species of the Leptospira genus. ELife 2021, 10: e64166. PMID: 33496263, PMCID: PMC7837694, DOI: 10.7554/elife.64166.Peer-Reviewed Original ResearchConceptsCross-protective immunityPathogenic Leptospira speciesTerms of morbidityLeptospira speciesTransient bacteremiaSingle doseAntibody responseImmune responseApplicable vaccinesVaccine candidatesAnimal modelsEffective preventionAttenuated mutantsZoonotic diseaseLeptospira genusPotential correlatesDisease transmissionDiseaseLeptospirosisImmunityBacteremiaMorbidityImmunizationVaccineRelevant proteinsKnowledge, Attitude, and Practices regarding Leptospirosis among Visitors to a Recreational Forest in Malaysia
Shafie NJ, Halim N, Zalipah M, Amin N, Esa S, Md-Nor S, Casanovas-Massana A, Ko AI, Palma F, Souza F, Costa F. Knowledge, Attitude, and Practices regarding Leptospirosis among Visitors to a Recreational Forest in Malaysia. American Journal Of Tropical Medicine And Hygiene 2021, 104: 1290-1296. PMID: 33534768, PMCID: PMC8045624, DOI: 10.4269/ajtmh.20-0306.Peer-Reviewed Original ResearchConceptsHigh-risk groupPractice scoresWorldwide public health problemCross-sectional studyPublic health problemHigher practice scoresHigher knowledge scoresAppropriate prevention programsGood practice habitsHigh riskHealth problemsKnowledge scorePrevention programsPractice habitsLeptospirosisMajority of respondentsLeptospirosis transmissionMajor causeDiseaseTransmission routesZoonotic diseaseHigher knowledgePotential outbreaksScoresFinal model
2019
Tails of Two Cities: Age and Wounding Are Associated With Carriage of Leptospira interrogans by Norway Rats (Rattus norvegicus) in Ecologically Distinct Urban Environments
Minter A, Himsworth C, Byers K, Childs J, Ko A, Costa F. Tails of Two Cities: Age and Wounding Are Associated With Carriage of Leptospira interrogans by Norway Rats (Rattus norvegicus) in Ecologically Distinct Urban Environments. Frontiers In Ecology And Evolution 2019, 7: 14. DOI: 10.3389/fevo.2019.00014.Peer-Reviewed Original ResearchNorway ratsL. interrogansSignificant human morbidityBite woundsGreater oddsGreater prevalenceJuvenile ratsOld ratsRatsHuman morbidityLeptospira interrogansZoonotic diseaseYoung animalsLinear mixed modelsTransmission dynamicsCarriageInterrogansPrevalencePrimary reservoirDistinct urban environmentsRat characteristicsPathogen statusMixed modelsStatusMorbidity