2025
Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana
Amegashie E, Kwayisi‐Darkwah C, Adusei‐Poku M, Sikeola R, Ativi L, Ahene A, Atampugbire G, Tagoe E, Paintsil E, Torpey K, Quaye O. Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana. Journal Of Medical Virology 2025, 97: e70301. PMID: 40110873, DOI: 10.1002/jmv.70301.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoinfectionCoronavirus InfectionsCross-Sectional StudiesCyclopropanesDideoxyadenosineDideoxynucleosidesFemaleGhanaGlutathioneHeterocyclic Compounds, 3-RingHIV InfectionsHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxazinesOxidative StressPiperazinesProspective StudiesPyridonesYoung AdultConceptsHuman immunodeficiency virusHuman immunodeficiency virus co-infectionCo-infectionGSH levelsART-experienced individualsPLWH co-infectedHuman coronavirusesHIV co-infectionHIV-negative individualsMalondialdehyde levelsOxidative stressOxidative stress markersIncreased MDA levelsCross-sectional studyOro-pharyngeal swabsImmunodeficiency virusGhanaian patientsMono-infectionReduced GSH levelsTreatment strategiesPlasma samplesDisease severityMDA levelsStress markersTailored monitoringIdentifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana
Mensah B, Mensah-Brown H, Partey F, Addo C, Buah G, Afudego G, Okyere D, Tetteh M, Boateng E, Wilson M, Paintsil E. Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana. BMC Public Health 2025, 25: 1042. PMID: 40102895, PMCID: PMC11917097, DOI: 10.1186/s12889-025-22254-w.Peer-Reviewed Original ResearchConceptsFactors associated with LTFUHigh-burden districtsIdentified risk factorsRisk factorsAssociated with loss to follow-upPromote health literacyCare of personsBackgroundLoss to follow-upLoss to follow-upGlobal health initiativesAssociated with LTFULogistic regression modelsAntiretroviral therapyHealth literacyHIV careHealth initiativesFollow-upNo educationHIV clinicEffective interventionsEffectiveness of treatment strategiesLTFUHospital visitsCareMethodsA retrospective analysis
2024
Prevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana
Gyane F, Modey E, Maya E, Bonney E, Abaidoo-Myles A, Paintsil E, Torpey K. Prevalence and risk factors associated with high-risk human papillomavirus infection among women living with HIV (WLWH) at a tertiary health facility in Accra, Ghana. PLOS ONE 2024, 19: e0303535. PMID: 38814956, PMCID: PMC11139324, DOI: 10.1371/journal.pone.0303535.Peer-Reviewed Original ResearchConceptsTertiary health facilityHealth facilitiesInterviewer-administered questionnaireAnalytical cross-sectional studyCervical cancer screeningCervical cancerPrevention of cervical cancerCross-sectional studyRisk factor assessmentHR-HPVAttending HIV clinicsCancer screeningHIV diagnosisLogistic regression analysisDemographic data collectionHigh-risk human papillomavirus infectionPrevalence of HR-HPVHIV clinicHigher oddsWLWHDescriptive statisticsStudy participantsHigh-risk patient groupsMultiple HPV genotypesPrevalence of HPV
2014
Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ Inhibition
Selvaraj S, Ghebremichael M, Li M, Foli Y, Langs-Barlow A, Ogbuagu A, Barakat L, Tubridy E, Edifor R, Lam W, Cheng Y, Paintsil E. Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ Inhibition. Clinical Pharmacology & Therapeutics 2014, 96: 110-120. PMID: 24637942, PMCID: PMC4065195, DOI: 10.1038/clpt.2014.64.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsATP-Binding Cassette TransportersCase-Control StudiesDeoxyribonucleotidesDNA Polymerase gammaDNA, MitochondrialDNA-Directed DNA PolymeraseFemaleGene DosageHIV InfectionsHumansMaleMiddle AgedMitochondriaNucleic Acid Synthesis InhibitorsNucleotide Transport ProteinsNucleotidesReverse Transcriptase InhibitorsRibonucleotidesConceptsAntiretroviral therapyPeripheral blood mononuclear cellsMitochondrial toxicityBlood mononuclear cellsNegative controlMitochondrial DNA copy numberMononuclear cellsDNA copy numberMitochondrial dysfunctionHigh expression levelsPotential mechanismsGroup differencesExpression levelsPositive controlTherapyMedian valueToxicityDeoxyribonucleotide poolsCellular kinasesCassette proteinCellsDysfunctionTriphosphateControl
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