2025
Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana
Amegashie E, Kwayisi‐Darkwah C, Adusei‐Poku M, Sikeola R, Ativi L, Ahene A, Atampugbire G, Tagoe E, Paintsil E, Torpey K, Quaye O. Lipid Peroxidation and Glutathione Levels Among People Living With HIV Co‐infected With Human Coronaviruses in Ghana. Journal Of Medical Virology 2025, 97: e70301. PMID: 40110873, DOI: 10.1002/jmv.70301.Peer-Reviewed Original ResearchMeSH KeywordsAdultCoinfectionCoronavirus InfectionsCross-Sectional StudiesCyclopropanesDideoxyadenosineDideoxynucleosidesFemaleGhanaGlutathioneHeterocyclic Compounds, 3-RingHIV InfectionsHumansLipid PeroxidationMaleMalondialdehydeMiddle AgedOxazinesOxidative StressPiperazinesProspective StudiesPyridonesYoung AdultConceptsHuman immunodeficiency virusHuman immunodeficiency virus co-infectionCo-infectionGSH levelsART-experienced individualsPLWH co-infectedHuman coronavirusesHIV co-infectionHIV-negative individualsMalondialdehyde levelsOxidative stressOxidative stress markersIncreased MDA levelsCross-sectional studyOro-pharyngeal swabsImmunodeficiency virusGhanaian patientsMono-infectionReduced GSH levelsTreatment strategiesPlasma samplesDisease severityMDA levelsStress markersTailored monitoringIdentifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana
Mensah B, Mensah-Brown H, Partey F, Addo C, Buah G, Afudego G, Okyere D, Tetteh M, Boateng E, Wilson M, Paintsil E. Identifying risk factors for loss to follow-up in adults living with HIV in a high-burden district in Ghana. BMC Public Health 2025, 25: 1042. PMID: 40102895, PMCID: PMC11917097, DOI: 10.1186/s12889-025-22254-w.Peer-Reviewed Original ResearchConceptsFactors associated with LTFUHigh-burden districtsIdentified risk factorsRisk factorsAssociated with loss to follow-upPromote health literacyCare of personsBackgroundLoss to follow-upLoss to follow-upGlobal health initiativesAssociated with LTFULogistic regression modelsAntiretroviral therapyHealth literacyHIV careHealth initiativesFollow-upNo educationHIV clinicEffective interventionsEffectiveness of treatment strategiesLTFUHospital visitsCareMethodsA retrospective analysis
2024
Asymptomatic malaria parasitaemia and virological non-suppression among children living with HIV in a low transmission area in Accra, Ghana: a cross-sectional study
Afrane A, Alhassan Y, Amoah L, Nyarko M, Addo-Lartey A, Paintsil E, Torpey K. Asymptomatic malaria parasitaemia and virological non-suppression among children living with HIV in a low transmission area in Accra, Ghana: a cross-sectional study. BMC Infectious Diseases 2024, 24: 1144. PMID: 39394078, PMCID: PMC11470549, DOI: 10.1186/s12879-024-09974-x.Peer-Reviewed Original ResearchConceptsVirological non-suppressionAsymptomatic malaria parasitaemiaKorle Bu Teaching HospitalLow transmission areasMalaria parasitaemiaAntiretroviral therapyNon-suppressionCross-sectional studyUndetectable viral load levelsProportion of HIV-infected childrenStudy populationBackgroundHuman immunodeficiency virusHIV-infected childrenPaediatric HIV clinicMalaria preventive behaviorsResultsThe median ageViral load levelsLow-level viraemiaTransmission areasMethodsThis cross-sectional studyAsymptomatic malariaMalaria parasitemiaMalaria casesChi-square testProportion of childrenScreening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence
Adu-Gyamfi R, Enos J, Yeboah K, Shabanova V, Hawley N, Ogum D, Nkansah A, Paintsil E, Torpey K. Screening for Hypertension in adolescents living with HIV: Protocol for a cluster randomized trial to improve guideline adherence. PLOS ONE 2024, 19: e0302016. PMID: 38701070, PMCID: PMC11068165, DOI: 10.1371/journal.pone.0302016.Peer-Reviewed Original ResearchConceptsTheory-based interventionsImplementation of clinical practice guidelinesClinic visitsProvision of job aidsHealthcare workers' adherenceCluster randomized trialAvailability of guidelinesClinical practice guidelinesBehavior-based interventionsCluster-randomized studyAntiretroviral therapy sitesCardiovascular disease-related morbidityBlood pressureAIDS-related deathsIntervention facilitiesGreater Accra Region of GhanaAccra Region of GhanaGuideline adherenceHypertension screeningAntiretroviral careWorker adherenceIncidence of hypertensionHypertension riskGreater Accra RegionJob aidsClinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV
Amegashie E, Asamoah P, Ativi L, Adusei-Poku M, Bonney E, Tagoe E, Paintsil E, Torpey K, Quaye O. Clinical outcomes and immunological response to SARS-CoV-2 infection among people living with HIV. Experimental Biology And Medicine 2024, 249: 10059. PMID: 38628843, PMCID: PMC11020089, DOI: 10.3389/ebm.2024.10059.Peer-Reviewed Original ResearchConceptsLevels of inflammatory markersResponse to SARS-CoV-2 infectionClinical outcomesSARS-CoV-2 infectionCo-infectionInflammatory markersSARS-CoV-2HIV patients co-infectedImmune response to SARS-CoV-2 infectionCD4<sup>+</sup> countInitiation of ARTT cell exhaustionPatients co-infectedSevere outcomesAssociated with severe outcomesStudy assessed risk factorsMono-infected individualsResponse to SARS-CoV-2Respiratory tract infectionsImmunological response to SARS-CoV-2Immunological response to SARS-CoV-2 infectionAfrican American raceChronic kidney diseaseIntensive care unitPositive conversion rate
2014
Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ Inhibition
Selvaraj S, Ghebremichael M, Li M, Foli Y, Langs-Barlow A, Ogbuagu A, Barakat L, Tubridy E, Edifor R, Lam W, Cheng Y, Paintsil E. Antiretroviral Therapy–Induced Mitochondrial Toxicity: Potential Mechanisms Beyond Polymerase‐γ Inhibition. Clinical Pharmacology & Therapeutics 2014, 96: 110-120. PMID: 24637942, PMCID: PMC4065195, DOI: 10.1038/clpt.2014.64.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsATP-Binding Cassette TransportersCase-Control StudiesDeoxyribonucleotidesDNA Polymerase gammaDNA, MitochondrialDNA-Directed DNA PolymeraseFemaleGene DosageHIV InfectionsHumansMaleMiddle AgedMitochondriaNucleic Acid Synthesis InhibitorsNucleotide Transport ProteinsNucleotidesReverse Transcriptase InhibitorsRibonucleotidesConceptsAntiretroviral therapyPeripheral blood mononuclear cellsMitochondrial toxicityBlood mononuclear cellsNegative controlMitochondrial DNA copy numberMononuclear cellsDNA copy numberMitochondrial dysfunctionHigh expression levelsPotential mechanismsGroup differencesExpression levelsPositive controlTherapyMedian valueToxicityDeoxyribonucleotide poolsCellular kinasesCassette proteinCellsDysfunctionTriphosphateControl
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