2025
Evaluation of dried blood spot with inductively coupled plasma mass spectrometry for trace toxic elements measurement in human biomonitoring
Sun Q, Wang Y, Cui W, Yu X, Bai X, Qiu T, Lu Y, Shi X. Evaluation of dried blood spot with inductively coupled plasma mass spectrometry for trace toxic elements measurement in human biomonitoring. Microchemical Journal 2025, 217: 115100. DOI: 10.1016/j.microc.2025.115100.Peer-Reviewed Original ResearchMass spectrometryInductively coupled plasma mass spectrometryInter-batch precisionLow detection limitPlasma mass spectrometryMatrix-matched calibrationDried Blood SpotsICP-MSMatrix effectsSample extraction methodMatrix interferencesDetection limitSatisfactory intra-Excellent linearityInternal standardWorking curveHuman biomonitoringTrace element determinationHuman whole bloodSpectrometryBlood spotsNational human biomonitoring programElement determinationHuman biomonitoring programsField-deployable methodUrinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study
Li C, Guo X, Ren H, Xu Y, Fang J, Sun P, Ding E, Lu Y, Li C, Zhao X, Long K, Cao K, Qian J, Chen Y, Wang Y, Deng F, Hou M, Shi Y, Cai Y, Tong S, Shen T, Tang S, Shi X. Urinary Organophosphate Esters and Increased Oxidative Stress in Healthy Older Adults: The China BAPE Study. Environment & Health 2025 DOI: 10.1021/envhealth.5c00050.Peer-Reviewed Original ResearchOlder adultsHealthy older adultsOrganophosphate estersAdverse health outcomesGeriatric diseasesDiphenyl phosphateQuantile g-computationGeneralized Additive Mixed ModelsExposure to organophosphate estersBayesian kernel machine regressionHealth hazardsHealth outcomesOPE exposureKernel machine regressionAdditive mixed modelsG-computationDibutyl phosphateBis(1,3-dichloro-2-propyl) phosphateAcute endocrine disrupting effect of fine particulate constituents on thyroid homeostasis: A multicenter cross-sectional study in China
Tian Y, Chen C, Li J, Liu S, Fang J, Zhao F, Tang S, Zhang Y, Du P, Wang J, Zhang Z, Li Y, Ding E, Liu Y, Wang F, Shi W, Sun Q, Hu J, Shi X. Acute endocrine disrupting effect of fine particulate constituents on thyroid homeostasis: A multicenter cross-sectional study in China. Ecotoxicology And Environmental Safety 2025, 303: 118976. PMID: 40925186, DOI: 10.1016/j.ecoenv.2025.118976.Peer-Reviewed Original ResearchConceptsImpacts of PM2.5Endocrine disrupting effectsBeijing-Tianjin-HebeiHeavy metalsAmbient fine particulate matterFine particulate matterAir pollutant concentrationsAssociated with thyroid hormone levelsThyroid hormone homeostasisPollutant concentrationsIQR increaseParticulate matterMonitoring stationsConstituent concentrationsParticulate constituentsThyroid homeostasisPbSurrounding areaMultiple linear regression modelZnHormone homeostasisThyroid hormone levelsMetalAssociated with T3CdAssociations of ambient particulate matter and nitrogen dioxide with hospital admissions for Parkinson's disease: A nationwide case-crossover study in China
Bai L, Jiang Y, Zhang K, Su H, Sun S, Deng F, Baccarelli A, Shi X, Guo X, Wu S. Associations of ambient particulate matter and nitrogen dioxide with hospital admissions for Parkinson's disease: A nationwide case-crossover study in China. Environmental Pollution 2025, 385: 127062. PMID: 40902708, DOI: 10.1016/j.envpol.2025.127062.Peer-Reviewed Original ResearchAssociation of PM2.5 wiAmbient particulate matterParticulate matterAir pollutionCo-exposureAssociation of ambient particulate matterCase-crossover studyNitrogen dioxideInterquartile range increaseLow concentration exposureHigh-concentration exposuresCoarse PMPD admissionsRange increasePrincipal discharge diagnosisPollutionHospital admissionPopulation-based evidenceHospital admission dataAssociated with increasesMedical insurance schemeMatterAirExposureDioxideAssociation of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study
Wang X, Zhong W, Chen Z, Song W, You F, Li Z, Lv Y, Liu D, Shi X, Mao C. Association of Adiposity Markers, Serum 25-Hydroxyvitamin D, and Frailty in Older Adults: A Prospective Cohort Study. American Journal Of Clinical Nutrition 2025 PMID: 40876539, DOI: 10.1016/j.ajcnut.2025.08.013.Peer-Reviewed Original ResearchWeight-adjusted waist indexAssociated with frailty riskBody roundness indexAdiposity markersFrailty riskOlder adultsProspective cohort studyFrailty indexCohort studyHigh frailty riskSerum 25-hydroxyvitamin DWaist indexRoundness indexSerum 25(OH)DBody shape indexAssociation of adiposityFollow-upBody mass indexFrailty preventionJoint associationsWaist circumferenceBiomarkers Cohort StudyHealth deficitsLinear mixed modelsLow serum 25(OH)DThe Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study
Yang J, Huang J, Huang Q, Gao J, Liu D, Li Z, Lv Y, Shi X, Mao C. The Impact of Social Stress and Healthy Lifestyle on the Mortality of Chinese Older Adults: Prospective Cohort Study. JMIR Aging 2025, 8: e75942. PMID: 40795324, PMCID: PMC12342692, DOI: 10.2196/75942.Peer-Reviewed Original Research[Association of cadmium internal exposure levels with blood lipid in adults aged 18 to 79 years in China].
Song H, Ji S, Li Z, Li Y, Zhao F, Qu Y, Lu Y, Han Y, Liu J, Cai J, Qiu T, Zhang W, Lin X, Cai J, Lyu Y, Shi X. [Association of cadmium internal exposure levels with blood lipid in adults aged 18 to 79 years in China]. Chinese Preventive Medicine 2025, 59: 1254-1263. PMID: 40829911, DOI: 10.3760/cma.j.cn112150-20241016-00819.Peer-Reviewed Original ResearchConceptsMultiple linear mixed effects modelsGeneralized linear mixed effects modelsAssociation of bloodLipid profile levelsChinese adultsLinear mixed effects modelsBlood cadmium levelsMulti-stage stratified random sampling methodMixed effects modelsPrevalence ratesConclusion:Results:LDL-CCross-sectional surveyUrinary cadmium levelsTotal cholesterolHDL-CLipoprotein cholesterolLow HDL-CHigh LDL-CEffects modelPrevalence rates of hypercholesterolemiaHigh-density lipoprotein cholesterolRates of hypercholesterolemiaExposure groupUrinary monohydroxylated polycyclic aromatic hydrocarbons among healthy elderly in the China BAPE study: Exposure characteristics, influencing factors, and health risks
Qian J, Guo X, Qi C, Sun P, Li C, Li C, Cao K, Xu Y, Ren H, Zhang J, Wang Y, Bao S, Qiu T, Wang C, Gu W, Lu Y, Tong S, Tang S, Shi X. Urinary monohydroxylated polycyclic aromatic hydrocarbons among healthy elderly in the China BAPE study: Exposure characteristics, influencing factors, and health risks. Journal Of Hazardous Materials 2025, 496: 139444. PMID: 40773834, DOI: 10.1016/j.jhazmat.2025.139444.Peer-Reviewed Original ResearchConceptsPolycyclic aromatic hydrocarbonsHealth risksHazard indexOH-PAHsPAH exposureUrinary OH-PAH concentrationsDietary exposure routeNon-carcinogenic riskPolycyclic aromatic hydrocarbon exposureOH-PAH concentrationsHuman health risksHealth risk assessmentRisk assessmentCarcinogenic risk assessmentConsumption of drinking waterAromatic hydrocarbonsExposure routesPartial burningMitigation policiesMixed-effects modeling techniquesDrinking waterComprehensive exposureCorn productionShandong ProvinceCarbon-based materialsCombined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study
Zhong W, Wang X, Chen H, Song W, Gao J, Chen P, Shen Q, You F, Li C, Lv Y, Li Z, Shi X, Mao C. Combined effects of physical activity, cognitive activity, and dietary patterns on cognitive impairment in older adults with consideration of APOE genotype: a cohort study. Alzheimer's Research & Therapy 2025, 17: 158. PMID: 40660329, PMCID: PMC12257734, DOI: 10.1186/s13195-025-01806-7.Peer-Reviewed Original ResearchConceptsCombined effects of physical activityEffects of physical activityPhysical activityApolipoprotein E genotypeRisk of cognitive impairmentHealthy dietHazard ratioCognitive impairmentOlder adultsDietary patternsActivity levelsLow risk of cognitive impairmentAdjusted Cox proportional hazards modelsMini-Mental State ExaminationNon-carriersOlder Chinese adultsApolipoprotein ELow riskCox proportional hazards modelsHigh PAProportional hazards modelDiet qualityCombination of activity levelMini-MentalChinese adultsAssociation between vegetarian diet and risk of frailty in Chinese older adults: a prospective study
Huang Y, Jigeer G, Lv Y, Wang K, Ma X, Zou J, Xia R, Shen X, Shi X, Li Y, Gao X. Association between vegetarian diet and risk of frailty in Chinese older adults: a prospective study. BMC Medicine 2025, 23: 352. PMID: 40598166, PMCID: PMC12211529, DOI: 10.1186/s12916-025-04232-6.Peer-Reviewed Original ResearchConceptsRisk of frailtyChinese older adultsOlder adultsAssociated with higher riskFrailty riskDiet trajectoriesIncident frailtyAssociated with higher risk of frailtyChinese community-dwelling older adultsMultivariable time-varying Cox proportional hazards modelsChinese Longitudinal Healthy Longevity SurveyPesco-vegetariansCommunity-dwelling older adultsHigher risk of frailtyHazard ratioTime-varying Cox proportional hazards modelsConfidence intervalsRisk of incident frailtyFree of frailtyFood frequency questionnaireVegetarian dietHigher risk of incident frailtyHigh riskCox proportional hazards modelsLongevity SurveyPhysical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study
Xu L, Wang J, Li X, Li Y, Chen C, Xu Z, Xia Y, Lu Z, Zhou J, Zhang M, Wei Y, Wu B, Zhang Z, Li F, Luo Y, Chen G, Lv Y, Shi X. Physical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study. BMC Medicine 2025, 23: 361. PMID: 40598362, PMCID: PMC12220457, DOI: 10.1186/s12916-025-04176-x.Peer-Reviewed Original ResearchConceptsPhysical activityRegular exerciseOlder adultsLeisure activitiesHealth benefits of physical activityBenefits of physical activityChinese Longitudinal Health Longevity SurveyProspective community-based cohort studyGenetic riskCommunity-based cohort studyHazard ratioChinese older adultsPhysical workFace-to-face interviewsHigh leisure activityAll-Cause MortalityPA recommendationsPA informationLongevity SurveyFace-to-faceMedian scoreCohort studyExerciseCox proportional risk modelHealth benefitsChlorinated paraffins in plasma of healthy elderly adults: Method development, temporal variability, and exposure determinants
Fang K, Guo X, He R, Sun Y, Huang Y, Cui H, Lu Y, Gu W, Wang C, Wan Y, Tang S, Shi X. Chlorinated paraffins in plasma of healthy elderly adults: Method development, temporal variability, and exposure determinants. Journal Of Hazardous Materials 2025, 495: 139065. PMID: 40580735, DOI: 10.1016/j.jhazmat.2025.139065.Peer-Reviewed Original ResearchConceptsShort-chain chlorinated paraffinsMedium-chain chlorinated paraffinsLong-chain chlorinated paraffinsChlorinated paraffinsMethod quantification limitsHuman internal exposureMethod detection limitsGroup of persistent organic pollutantsLinear mixed-effects modelsTemporal variabilityPersistent organic pollutantsPrimary exposure pathwayCP exposureInternal exposureDietary pathwayExposure pathwaysPersistent pollutantsBiomonitoring samplesOrganic pollutantsVSCCPsExposure dynamicsDetection frequencyHealth risksShort-term variationsMixed-effects modelsAssociations between urinary polycyclic aromatic hydrocarbons and glycometabolic markers and potential mechanisms in healthy older adults: The China BAPE study
Li C, Fang J, Xu Y, Yang J, Ren H, Cao K, Ding E, Wang Y, Li C, Zhang J, Guo X, Qian J, Lu Y, Tong S, Tang S, Shi X. Associations between urinary polycyclic aromatic hydrocarbons and glycometabolic markers and potential mechanisms in healthy older adults: The China BAPE study. Journal Of Hazardous Materials 2025, 495: 139069. PMID: 40582155, DOI: 10.1016/j.jhazmat.2025.139069.Peer-Reviewed Original ResearchConceptsUrinary PAH metabolitesMonthly follow-up visitsPolycyclic aromatic hydrocarbonsReactive oxygen speciesFollow-up visitPotential mechanismsType 2 diabetesPolycyclic aromatic hydrocarbon exposureUrine metabolomePAH metabolitesMetabolic healthMetabolic perturbationsMetabolic disordersAdverse outcome pathwayOlder adultsAromatic hydrocarbonsDiverse cohortPolycyclic aromatic hydrocarbon compoundsOxidative stressMarkersMolecular initiating eventUrinary polycyclic aromatic hydrocarbonsOxygen speciesMetabolitesAdultsAssociations of White Blood Cell, Platelet Count, Platelet-to-White Blood Cell Ratio with Muscle Mass among Community-Dwelling Older Adults in China
Zhang Z, Zhao Y, Chen H, Qi L, Chen C, Wang J, Shi W, Lyu Y, Shi X. Associations of White Blood Cell, Platelet Count, Platelet-to-White Blood Cell Ratio with Muscle Mass among Community-Dwelling Older Adults in China. Biomedical And Environmental Sciences 2025, 38: 693-705. PMID: 40616485, DOI: 10.3967/bes2025.051.Peer-Reviewed Original ResearchConceptsOlder adultsMuscle massCommunity-dwelling older adultsAssociation of WBC countSkeletal muscle mass indexWhite blood cellsPlatelet countAssociation of white blood cellChinese older adultsMuscle mass indexManagement of sarcopeniaCross-sectional analysisMultivariate linear regressionBioelectrical impedance analysisInflammatory markersMuscle mass lossMonitoring of inflammatory markersPlatelet-to-white blood cell ratioBiomarkers Cohort StudyWBC countStratified analysisCohort studyBlood cellsMale participantsMass indexThree-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study
Zhong W, Wang X, Song W, Chen H, Xie J, Yan H, Wang J, Lv Y, Li Z, Shi X, Mao C. Three-year lifestyle changes, genetic risk, and risk of frailty among older adults: A national community-based cohort study. Clinical Nutrition 2025, 50: 29-37. PMID: 40367593, DOI: 10.1016/j.clnu.2025.04.033.Peer-Reviewed Original ResearchConceptsRisk of frailtyGenetic riskHealthy lifestyleUnhealthy lifestyleOlder adultsFrailty riskLate-lifeLifestyle changesChinese Longitudinal Healthy Longevity SurveyCommunity-based cohort studyHazard ratioPolygenic risk scoresGenetic risk groupsModerate-to-moderatelyCox proportional hazards regression modelsProportional hazards regression modelsLifestyle scoreHazards regression modelsLongevity SurveyHigh frailty riskPrevent frailtyLifestyle factorsFrailty indexCohort studyLifestyle combinationAir Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights
Jiang M, Wang Y, Tian S, Liu S, Luo Y, Song H, Qin J, Lv Y, Baccarelli A, Zhang Z, Shi X, Gao X. Air Pollution Control Mitigates Frailty Progression: Evidence from Two Cohorts of Older Adults and DNA Methylation Insights. Environmental Science And Technology 2025, 59: 9907-9917. PMID: 40353491, DOI: 10.1021/acs.est.4c13675.Peer-Reviewed Original ResearchConceptsChinese Longitudinal Healthy Longevity StudyAssociated with PM2.5 exposure inOlder adultsAir quality improvementHealth and Aging StudyClean Air ActEnvironmental policy interventionsQuasi-experimental studyRisk of worsening frailtyAir ActRange reductionKnowledge gapsLikelihood of improvementFrailty progressionNationwide cohortFollow-up visitFrailty burdenQuality improvementProspective cohortSurvey wavesAging StudyFrailtyMultistate modelling analysisFollow-up dataHealth benefits[Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis].
Zhao Y, Zhang Z, Wang J, Zhou J, Chen H, Qi L, Li Y, Chen Y, Meng X, Zhang Z, Chen C, Shi X, Lyu Y, Shi W. [Association between dietary behavior and sarcopenia in older adults aged 65 years and above in longevity areas of China: a latent class analysis]. Chinese Journal Of Epidemiology 2025, 46: 746-752. PMID: 40494780, DOI: 10.3760/cma.j.cn112338-20241117-00729.Peer-Reviewed Original ResearchConceptsDietary behaviorsOlder adultsCategory scoresLatent class analysisDietary intakeFood intake frequencyRisk of sarcopeniaIncreased riskBalanced dietary patternFood frequency questionnaireIntake of cerealsMultivariate logistic regression modelChronic disease historyNon-sarcopenia groupLogistic regression modelsClass analysisIntake categoriesSARC-CalF.Frequency questionnaireBiomarkers Cohort StudyIntake frequencyDietary patternsSarcopenia groupCohort studyLongevity areas[Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China].
Xu H, Wu Y, Chen C, Meng X, Chen J, Zhang Z, Zhong Z, Yang J, Fu X, Chen S, Chen Y, Li Z, Ye L, Shi X, Lyu Y. [Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China]. Chinese Journal Of Epidemiology 2025, 46: 753-760. PMID: 40494781, DOI: 10.3760/cma.j.cn112338-20250124-00060.Peer-Reviewed Original ResearchConceptsLevels of physical activityPhysical activityOlder adultsCognitive impairmentIntensity levels of physical activityIntensity of physical activityPhysical Activity ScaleChronic disease historyWork-related activitiesMultifactorial logistic regression modelsLogistic regression modelsMini-MentalBiomarkers Cohort StudyChinese versionActivity ScaleActive leisureCohort studyLongevity areasDemographic characteristicsHealthy agingDisease historyHousehold activitiesRegression modelsCognitive functionNegative association[Association between dietary behavior and type 2 diabetes in the older adults aged 65 years and over in 18 longevity areas of China].
Hu X, Chen Y, Zhang Z, Chen C, Qu Y, Meng X, Wang J, Xu Z, Li Z, Liu S, Shi W, Xue Z, Long F, Shi X, Lyu Y. [Association between dietary behavior and type 2 diabetes in the older adults aged 65 years and over in 18 longevity areas of China]. Chinese Preventive Medicine 2025, 59: 588-596. PMID: 40374347, DOI: 10.3760/cma.j.cn112150-20241231-01064.Peer-Reviewed Original ResearchConceptsPlant-based diet indexRisk of T2DMAssociated with T2DMMultivariate logistic regressionLongevity areasDiet indexOlder adultsPrevalence rates of T2DMSelf-health statusLogistic regressionFood intake frequencyRate of T2DMDietary behaviorsFood frequencyBiomarkers Cohort StudyIntake frequencyHigher adherenceType 2 diabetes mellitusFasting venous bloodHigh-level groupCohort studyLow-level groupPrevalence ratesDemographic characteristicsDaily activities[Analysis of the levels and food source of cadmium exposure by dietary pathway among middle-aged and elderly populations in cadmium-contaminated areas of China].
Wang X, Zhang Y, Dong X, Hao R, Ye X, Zhang W, Zhu Y, Liu A, Wei Y, Wu B, Luo Y, Wu C, Ma Y, Yang Z, Lyu Y, Ding G, Xu D, Shi X. [Analysis of the levels and food source of cadmium exposure by dietary pathway among middle-aged and elderly populations in cadmium-contaminated areas of China]. Chinese Preventive Medicine 2025, 59: 597-603. PMID: 40374348, DOI: 10.3760/cma.j.cn112150-20240718-00580.Peer-Reviewed Original ResearchConceptsDietary cadmium intakeCadmium-contaminated areasProvisional Tolerable Monthly IntakeCadmium intakeTotal Diet StudyJoint FAO/WHO Expert Committee on Food AdditivesDietary pathwayFood frequency questionnaireSource of cadmium exposureAreas of ChinaFAO/WHO Expert Committee on Food AdditivesCadmium contentMiddle-agedCadmium exposureDiet studiesMonthly intakeElderly peopleDietary recall surveyFood sourcesStaple foodSurvey regionFrequency questionnaireIntake frequencyVegetationStudy subjects
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