2024
Associations of Serum Per- and Polyfluoroalkyl Substances with Hyperuricemia in Adults: A Nationwide Cross-Sectional Study
Zheng X, Pan Y, Qu Y, Ji S, Wang J, Li Z, Zhao F, Wu B, Xie L, Li Y, Song H, Hu X, Qiu Y, Zhang Z, Zhang W, Yang Y, Cai J, Zhu Y, Zhu Y, Cao Z, Ji J, Lv Y, Dai J, Shi X. Associations of Serum Per- and Polyfluoroalkyl Substances with Hyperuricemia in Adults: A Nationwide Cross-Sectional Study. Environmental Science And Technology 2024 PMID: 38980177, DOI: 10.1021/acs.est.3c11095.Peer-Reviewed Original ResearchNationwide cross-sectional studyPublic health planningCross-sectional studyOdds of hyperuricemiaChinese adultsHealth plansJoint effectsElevated oddsGeneral populationNationwide studyNonmonotonic dose responsePositive associationRisk factorsAdultsHealthEffects of polyfluoroalkyl substancesHealth hazardsParticipantsSerum polyfluoroalkyl substancesJoint effects of PFAS mixtureMeasured serum concentrationsFish consumptionSerum concentrations of uric acidAssociationHyperuricemiaAnalysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study
Huang Q, Zhang P, Shen D, Gao J, Li Z, Lv Y, Shi X, Mao C. Analysis of changes in social isolation, loneliness, or both, and subsequent cognitive function among older adults: Findings from a nationwide cohort study. Alzheimer's & Dementia 2024 PMID: 38946708, DOI: 10.1002/alz.14080.Peer-Reviewed Original ResearchAssociated with accelerated cognitive declineCognitive impairment riskPersistent lonelinessSocial isolationCognitive declineOlder adultsImpairment riskChinese Longitudinal Healthy Longevity SurveyIncident cognitive impairmentCognitive impairmentAssociation of changesNationwide cohort studyAccelerated cognitive declineCognitive functionLongevity SurveyCohort studyChanging statusLonelinessRisk factorsRegression modelsTobit regression modelCox modelShort-termRiskAdultsMetabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study
Song W, Zhong W, Gao J, Li Z, Ren J, Shen D, Wang X, Shen Q, You F, Fu Q, Li C, Chen H, Lv Y, Shi X, Mao C. Metabolic obesity phenotypes and all-cause mortality among the Chinese oldest-old population: a prospective cohort study. International Journal Of Obesity 2024, 1-9. PMID: 38926462, DOI: 10.1038/s41366-024-01571-x.Peer-Reviewed Original ResearchMetabolically unhealthy non-obeseMetabolically healthy non-obeseMetabolically healthy obesityMetabolic obesity phenotypesOldest-old populationMetabolically unhealthy obesityProspective cohort studyMortality riskCohort studyHazard ratioObese phenotypeManagement of metabolic healthUnhealthy non-obeseOldest-old adultsHealthy non-obeseMethodsThis prospective cohort studyDecreased mortality riskIncreased mortality riskHigher mortality riskYears of follow-upAll-cause mortalityNon-obeseEffect of obesityHealthy obesityCentral obesityPersonal exposure to airborne organic pollutants and lung function changes among healthy older adults
Guo X, Ren H, Sun P, Ding E, Fang J, Fang K, Ma X, Li C, Li C, Xu Y, Cao K, Lin E, Guo P, Pollitt K, Tong S, Tang S, Shi X. Personal exposure to airborne organic pollutants and lung function changes among healthy older adults. Environmental Research 2024, 258: 119411. PMID: 38876423, DOI: 10.1016/j.envres.2024.119411.Peer-Reviewed Original Research[Prediction model related to 6-year risk of frailty in older adults aged 65 years or above in China].
Zhou J, Qi L, Wang J, Liu S, Shi W, Ye L, Zhang Z, Zhang Z, Meng X, Cui J, Chen C, Lyu Y, Shi X. [Prediction model related to 6-year risk of frailty in older adults aged 65 years or above in China]. Chinese Journal Of Epidemiology 2024, 45: 809-816. PMID: 38889980, DOI: 10.3760/cma.j.cn112338-20231205-00333.Peer-Reviewed Original ResearchConceptsDaily living scoresPredictors of frailtyArea under the receiver operating characteristic curveIncident frailtyOlder adultsLiving scoresChinese Longitudinal Healthy Longevity SurveyRisk thresholdSelf-rated healthChinese older adultsRisk of incident frailtyRisk of frailtyFree of frailtyPhysical examination variablesCox proportional hazards regression modelsProportional hazards regression modelsRisk prediction modelInstrumental activitiesHazards regression modelsLongevity SurveyFrailty incidenceFollow-up timeDecision-curve analysisOlder personsReceiver operating characteristic curvePositive Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Hypertension May Be Attenuated by Endogenous Sex Hormones: A Nationally Representative Cross-Sectional Study
Wu B, Sheng N, Li Z, Wang J, Ji S, Zhao F, Pan Y, Qu Y, Wei Y, Xie L, Li Y, Hu X, Wu C, Zhang Z, Qiu Y, Zheng X, Zhang W, Hu X, Song H, Cai J, Cao Z, Ji J, Lv Y, Dai J, Shi X. Positive Associations of Perfluoroalkyl and Polyfluoroalkyl Substances With Hypertension May Be Attenuated by Endogenous Sex Hormones: A Nationally Representative Cross-Sectional Study. Hypertension 2024, 81: 1799-1810. PMID: 38853753, DOI: 10.1161/hypertensionaha.123.22127.Peer-Reviewed Original ResearchDiastolic blood pressureSystolic blood pressureEndogenous sex hormonesBlood pressureNationally representative cross-sectional studyPositive associationPerfluoroheptane sulfonic acidWeighted multiple logistic regressionSex hormonesLevels of endogenous sex hormonesPrevalence of hypertensionCross-sectional studyMultiple logistic regressionAssociations of polyfluoroalkyl substancesPFAS mixtureJoint effects of PFAS mixtureAssociated with hypertensionProgression of hypertensionChinese adultsSynergy indexOdds ratioG-computationQuantile-based g-computationRisk ratioLogistic regressionA Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults — China, 2017–2021
Qiu Y, Ji S, Chen C, Zhou J, Wang J, Wu B, Wei Y, Li F, Zheng X, Xu L, Zhang Z, Zhao F, Chen G, Ji J, Lyu Y, Tong S, Shi X. A Prospective Cohort Study of Antimony Exposure and Cognitive Impairment in Older Adults — China, 2017–2021. China CDC Weekly 2024, 6: 537-541. PMID: 38933661, PMCID: PMC11196874, DOI: 10.46234/ccdcw2024.104.Peer-Reviewed Original Research[Exploring implementation strategies for healthy longevity among the elderly population in China based on the delphi method].
Chai X, Cui J, Ye L, Lyu Y, Shao R, Zhang J, Shi X. [Exploring implementation strategies for healthy longevity among the elderly population in China based on the delphi method]. Chinese Preventive Medicine 2024, 58: 883-890. PMID: 38955737, DOI: 10.3760/cma.j.cn112150-20230804-00056.Peer-Reviewed Original ResearchConceptsHarmony coefficientsImplementation strategiesHealthy longevityAuthority coefficientPromote healthy longevityExpert active coefficientElderly populationChinese elderly populationDelphi methodDelphi consultationConsultation questionnaireElderly care service industryPublic healthFeasibility scoreScore of feasibilityAverage scoreConsultationExpert discussionScoresLiterature reviewClinical medicineHealthy Lifestyle and the Likelihood of Becoming a Centenarian
Li Y, Wang K, Jigeer G, Jensen G, Tucker K, Lv Y, Shi X, Gao X. Healthy Lifestyle and the Likelihood of Becoming a Centenarian. JAMA Network Open 2024, 7: e2417931. PMID: 38900423, PMCID: PMC11190803, DOI: 10.1001/jamanetworkopen.2024.17931.Peer-Reviewed Original ResearchConceptsHealthy lifestyleCase-control studyLifestyle factorsOlder adultsChinese Longitudinal Healthy Longevity SurveySelf-reported chronic conditionsHealthy lifestyle scoreImprove lifestyle behaviorsChinese older adultsAssociated with life expectancyProspective nested case-control studyNested case-control studyLifestyle scoreLifestyle behaviorsLongevity SurveyOlder age groupsHealth outcomesChronic conditionsSociodemographic characteristicsCommunity-basedMental wellnessYear of entryMain OutcomesOdds ratioMiddle-agedDietary seafood as a potential modifier in the relationship between per- and polyfluoroalkyl substances (PFASs) burden and prediabetes/diabetes: Insights from a nationally representative cross-sectional study
Qu Y, Sheng N, Ji S, Li Z, Wang J, Pan Y, Hu X, Zheng X, Li Y, Song H, Xie L, Zhang W, Cai J, Zhao F, Zhu Y, Cao Z, Lv Y, Dai J, Shi X. Dietary seafood as a potential modifier in the relationship between per- and polyfluoroalkyl substances (PFASs) burden and prediabetes/diabetes: Insights from a nationally representative cross-sectional study. Journal Of Hazardous Materials 2024, 473: 134645. PMID: 38762989, DOI: 10.1016/j.jhazmat.2024.134645.Peer-Reviewed Original ResearchPolyfluoroalkyl substancesSeafood consumptionImpact of polyfluoroalkyl substancesPFAS burdenPFAS levelsHuman biomonitoring dataEffects of PFAS exposureDietary seafoodSeafood consumersCl-PFESABiomonitoring dataSeafood intakePFAS concentrationsPolyfluoroalkyl substances exposuresSeafoodLevels of PERPFAS exposurePFOSPolyfluoroalkylNon-linear relationshipSerum PFAS concentrationsPERPrevalence of prediabetesPFOAPFUnDAHeat exposure induced risks of preterm birth mediated by maternal hypertension
Wang L, Di J, Wang Q, Zhang H, Zhao W, Shi X, Di Q, Ji J, Liang W, Huang C. Heat exposure induced risks of preterm birth mediated by maternal hypertension. Nature Medicine 2024, 1-8. PMID: 38750350, DOI: 10.1038/s41591-024-03002-w.Peer-Reviewed Original ResearchRisk of maternal hypertensionRisk of preterm birthMaternal hypertensionPreterm birthClinical subtypes of preterm birthIncreased risk of preterm birthSubtypes of preterm birthIncidence of preterm birthBlood pressureMaternal blood pressureSingleton live birthsElevated blood pressureGestational weeksLarge-population studiesEarly pregnancyLive birthsClinical subtypesCohort studyIncreased riskHypertensionBirthMediation analysisEffects of heat exposureHeat exposureExposure[Exploring a definition of healthy longevity in Chinese population based on Delphi method].
Chai X, Cui J, Ye L, Zhou J, Shao R, Shi X, Lyu Y, Zhang J. [Exploring a definition of healthy longevity in Chinese population based on Delphi method]. Chinese Preventive Medicine 2024, 58: 629-635. PMID: 38715502, DOI: 10.3760/cma.j.cn112150-20230924-00220.Peer-Reviewed Original ResearchConceptsHealthy longevityMental healthNon-communicable disease indicatorsSelf-rated healthTwo-round Delphi consultationCognitive functionWell-beingChinese populationFunctions of daily lifeHigh disability rateSubjective well-beingGeriatric healthDelphi consultationPhysical healthFunctional abilityHearing functionElderly care service industryDelphi surveyExpert consultationDisability rateHealthPublic healthMeasurement toolsMultiple-choice questionsFamily membersBody mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study
Lv Y, Zhang Y, Li X, Gao X, Ren Y, Deng L, Xu L, Zhou J, Wu B, Wei Y, Cui X, Xu Z, Guo Y, Qiu Y, Ye L, Chen C, Wang J, Li C, Luo Y, Yin Z, Mao C, Yu Q, Lu H, Kraus V, Zeng Y, Tong S, Shi X. Body mass index, waist circumference, and mortality in subjects older than 80 years: a Mendelian randomization study. European Heart Journal 2024, 45: 2145-2154. PMID: 38626306, PMCID: PMC11212828, DOI: 10.1093/eurheartj/ehae206.Peer-Reviewed Original ResearchChinese Longitudinal Healthy Longevity SurveyHigher body mass indexAssociation of body mass indexBody mass indexNon-CVD mortalityOldest-old peopleWaist circumferenceOldest-oldMortality riskMendelian randomizationSingle-nucleotide polymorphismsInverse relationship of BMIStudies of body mass indexRelationship of body mass indexCardiovascular diseaseOptimal body mass indexMass indexAssociated with body mass indexCardiovascular disease mortalityMendelian randomization studiesAssociated with decreased mortality riskGenetic risk scoreNon-linear MR analysisLower mortality riskJoint effect analysisAccountability analysis of health benefits related to National Action Plan on Air Pollution Prevention and Control in China
Li T, Chen C, Zhang M, Zhao L, Liu Y, Guo Y, Wang Q, Du H, Xiao Q, Liu Y, He M, Kinney P, Cohen A, Tong S, Shi X. Accountability analysis of health benefits related to National Action Plan on Air Pollution Prevention and Control in China. PNAS Nexus 2024, 3: pgae142. PMID: 38689709, PMCID: PMC11060103, DOI: 10.1093/pnasnexus/pgae142.Peer-Reviewed Original ResearchBeijing-Tianjin-HebeiAir pollution preventionEffects of PM<sub>2.5</sub>Pollution preventionAir pollution control measuresCoal emissionsAir pollution sourcesPollution control measuresHealth effectsNational Action PlanAcute health effectsPollution sourcesQuasi-Poisson regression modelCoal combustionAction planConsumer of coalCirculatory mortalityReduce emissionsRandom-effects meta-analysisHealth benefitsEffects meta-analysisTwo-stage analysis strategySignificant health benefitsControl measuresAirHeavy metals and metalloids exposure and liver function in Chinese adults — A nationally representative cross-sectional study
Wang S, Lyu Y, Ji S, Liu N, Wu B, Zhao F, Li Z, Qu Y, Zhu Y, Xie L, Li Y, Zhang Z, Song H, Hu X, Qiu Y, Zheng X, Zhang W, Yang Y, Li F, Cai J, Zhu Y, Cao Z, Tan F, Shi X. Heavy metals and metalloids exposure and liver function in Chinese adults — A nationally representative cross-sectional study. Environmental Research 2024, 252: 118653. PMID: 38518907, DOI: 10.1016/j.envres.2024.118653.Peer-Reviewed Original ResearchHeavy metalsEffects of heavy metalsChinese adultsHuman biomonitoring surveyMetalloid exposureBiomonitoring surveysEnvironmental presenceSample of Chinese adultsBenefits of seleniumCross-sectional studyHigher concentrationsNo significant associationMetalloidsLiver functionAspartate aminotransferaseAlcohol consumptionAlanine aminotransferaseAlcohol intakeSeleniumManganeseSignificant associationHealthMetalLiver healthAnalyzed dataAssociation between exposure to chemical mixtures and epigenetic ageing biomarkers: Modifying effects of thyroid hormones and physical activity
Shi W, Fang J, Ren H, Sun P, Liu J, Deng F, Zhang S, Wang Q, Wang J, Tong S, Tang S, Shi X. Association between exposure to chemical mixtures and epigenetic ageing biomarkers: Modifying effects of thyroid hormones and physical activity. Journal Of Hazardous Materials 2024, 469: 134009. PMID: 38492399, DOI: 10.1016/j.jhazmat.2024.134009.Peer-Reviewed Original ResearchPolycyclic aromatic hydrocarbonsChemical mixture exposureOrganophosphate estersPolyfluoroalkyl substancesMixture exposurePhysical activityAir pollution exposureExposure to chemical mixturesEffects of environmental chemicalsLevels of physical activityAromatic hydrocarbonsPollution exposureHealthy ageing strategiesAged care policyChemical mixturesHealthy older adultsEnvironmental chemicalsEpigenetic ageing biomarkersAdverse effects of environmental chemicalsAcceleration of population agingLifestyle factorsCare policyOlder adultsHormone homeostasisPhthalateAssociations of environmental cadmium exposure with kidney damage: Exploring mediating DNA methylation sites in Chinese adults
Wei Y, Wang X, Sun Q, Shi W, Zhang W, Gao X, Li Y, Hao R, Dong X, Chen C, Cao K, Jiang W, Yang Z, Zhu Y, Lv Y, Xv D, Li J, Shi X. Associations of environmental cadmium exposure with kidney damage: Exploring mediating DNA methylation sites in Chinese adults. Environmental Research 2024, 251: 118667. PMID: 38462081, DOI: 10.1016/j.envres.2024.118667.Peer-Reviewed Original ResearchDifferentially methylated positionsUrinary CdDNA methylationAssociated with urinary CdSource of cadmiumExposure to CdEnvironmental Cd exposureNon-smoking adultsCd-induced kidney damageCd exposureEnvironmental CdDNA methylation sitesDNA methylation changesIllumina Infinium MethylationEPIC BeadChip arrayDNA methylation profilesEpigenome-wide associationInfinium MethylationEPIC BeadChip arrayLinear mixed-effects modelsMethylationEPIC BeadChip arrayEnvironmental pollutionPerspective of environmental pollutionMethylation sitesMethylation changesBeadChip arrayMethylation profilesAssociations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China
Ni W, Lv Y, Yuan X, Zhang Y, Zhang H, Zheng Y, Shi X, Xu J. Associations of Low-density Lipoprotein Cholesterol With All-cause and Cause-specific Mortality in Older Adults in China. The Journal Of Clinical Endocrinology & Metabolism 2024, dgae116. PMID: 38436437, DOI: 10.1210/clinem/dgae116.Peer-Reviewed Original ResearchCause-specific mortalityAssociation of low-density lipoprotein cholesterolAll-causeOlder adultsLDL-C levelsLow-density lipoprotein cholesterolAssociated with increased cancer mortalityHazard ratioRisk of all-cause mortalityCVD-specific mortalityLDL-CMultivariable-adjusted HRCardiovascular diseaseProspective cohort studyLipoprotein cholesterolAll-cause mortalityCox proportional hazards modelsOther-cause mortalityHealthy aging researchProportional hazards modelCancer mortalityVital statusMultivariate Cox proportional hazards modelLow LDL-C levelsMedian follow-up time[Association of urinary cadmium level with body mass index and body circumferences among older adults over 65 years old in 9 longevity areas of China].
Zhang Z, Wu B, Qu Y, Li Y, Xu L, Lyu C, Chen C, Wang J, Xue K, Wei Y, Zhou J, Zheng X, Qiu Y, Luo Y, Liu J, Lyu Y, Shi X. [Association of urinary cadmium level with body mass index and body circumferences among older adults over 65 years old in 9 longevity areas of China]. Chinese Preventive Medicine 2024, 58: 227-234. PMID: 38387955, DOI: 10.3760/cma.j.cn112150-20230912-00181.Peer-Reviewed Original ResearchConceptsBody mass indexWaist circumferenceHip circumferenceCalf circumferenceOlder adultsBody circumferencesLongevity areasUrinary cadmium levelsLinear regression modelsMultiple linear regression modelUrinary cadmium concentrationCadmium levelsUrinary cadmiumAssociated with decreased BMIChange of body mass indexCadmium concentrationsRegression modelsSocio-demographic characteristicsRestricted cubic spline curvesRestricted cubic splinesAge of subjectsBiomarkers Cohort StudyHealth statusNegative linear associationWaistDetermination of persistent organochlorine pollutants in human serum by combining liquid-liquid extraction and solid-phase extraction with gas chromatography-tandem mass spectrometry
Qiu T, Jiang W, Bao S, Qian J, Wang C, Tang S, Shi X, Lu Y. Determination of persistent organochlorine pollutants in human serum by combining liquid-liquid extraction and solid-phase extraction with gas chromatography-tandem mass spectrometry. Microchemical Journal 2024, 197: 109699. DOI: 10.1016/j.microc.2023.109699.Peer-Reviewed Original ResearchSolid-phase extractionGas chromatography-tandem mass spectrometryLiquid-liquid extractionPersistent organochlorine pollutantsChromatography-tandem mass spectrometryMatrix effectsTarget analytesMass spectrometryMultiple reaction monitoring (MRM) modeReaction monitoring modeMethod detection limitsOrganochlorine pollutantsElectron impactSample preparation procedureGC-MS/MSDifferent spike levelsHuman serumApplicable analytical methodsLimit of quantificationMethyl tert-butyl etherQuality control samplesMonitoring modeTert-butyl etherDetection limitPreparation procedure