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INFORMATION FOR

Ying Chen, MD, PhD

Associate Professor of Epidemiology (Environmental Health)
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Contact Info

ying.chen@yale.edu
203.785.4694

Environmental Health Sciences

60 College St, LEPH 521

New Haven, CT 06520

United States

About

Titles

Associate Professor of Epidemiology (Environmental Health)

Biography

Dr. Chen has a broad background in environmental genetics and molecular toxicology, with specific training and expertise in redox biology, oxidative stress related diseases, and transgenic mouse models of redox dysregulation. Her research over the past ten years utilizes unique animal models and applies the system biology approach integrating multi-omics data and histopathology to understand the mechanistic roles of redox homeostasis in disease conditions related to environmental and dietary exposures.

  1. How does redox-elicited modifications of the liver proteome tune cellular response to protect against alcohol-associated fatty liver disease?
  2. Does oxidative stress play a mutagenic role in emerging water contaminant 1,4-dioxane-induced liver cancer
  3. What is the functional crosstalk between antioxidants in the central nervous system as they relate to neuronal health and disease?
  4. What is the translational importance of these new knowledge in risk assessment, disease prevention and treatment? 
Last Updated on February 19, 2023.

Appointments

Other Departments & Organizations

Education & Training

Postdoctoral Research Associate
University of Colorado (2010)
Postdoctoral fellow
University of Cincinnati (2008)
PhD
University of Cincinnati, Department of Environmental and Public Health Sciences (2007)
MD
Xiangya School of Medicine, Clinical Medicine (1994)

Research

Overview

Dr. Chen’s research focuses on understanding the mechanistic functions of redox homeostasis and antioxidant deficiencies in human diseases associated with environmental and dietary stress. Reduced GSH is the most abundant thiol antioxidant that combats excessive oxidants generated during cellular metabolism or in response to environmental assaults. GSH deficiency has been associated with numerous pathological conditions in human. Dr. Chen’s research work involves the use of unique redox animal models and system biology approach to elucidate the molecular mechanisms underlying liver diseases and neurological disorders. 

Specific research projects include:

  • Redox-mediated mechanisms in protection against alcohol-associated fatty liver disease
  • The mechanistic role of oxidative stress in water contaminant 1,4-dioxane-induced liver cytotoxicity and genotoxicity
  • The functional interplay between two  antioxidants (glutathione and ascorbate) in the central nervous system

Medical Research Interests

Digestive System Diseases; Disorders of Environmental Origin; Nervous System Diseases; Nutritional and Metabolic Diseases

Public Health Interests

Metabolomics; Genetics, Genomics, Epigenetics; Environmental Health; Cancer

Research at a Glance

Yale Co-Authors

Frequent collaborators of Ying Chen's published research.

Publications

2025

2024

2023

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Academic Achievements & Community Involvement

Activities

  • activity

    National Institute of Environmental Health Sciences

    2024 - PresentPeer Review Groups and Grant Study SectionsAd-hoc reviewer
  • activity

    Yale School of Public Health Stolwijk Fellowship

    2023 - PresentCommitteesCommittee Member

Get In Touch

Contacts

Email
Academic Office Number
Lab Number
Office Fax Number
Mailing Address

Environmental Health Sciences

60 College St, LEPH 521

New Haven, CT 06520

United States

Locations

  • Yale School of Public Health (LEPH)

    Lab

    60 College Street, Fl 5th, Rm 508

    New Haven, CT 06510

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