About
Research
Overview
In the Iwasaki Laboratory, we focus on understanding how viruses infect the host through the mucosal surfaces to cause diseases, how the immune system deals with viral infections within these local tissues, how acute infections lead to long-term diseases, and to use such insights to design vaccines and therapeutics against acute & chronic viral diseases, post-viral diseases, autoimmunity, and cancer. We study immune responses to a variety of viruses including herpes simplex viruses, Zika virus, influenza viruses, rhinoviruses, and retroviruses - with the most recent focus on SARS-CoV-2. Our studies have led to the development of mucosal vaccines that can prevent infection, transmission, and recurrent diseases.
Our research addresses mechanisms of innate immune recognition of viruses and initiation of adaptive antiviral immunity, particularly at the natural site of virus encounter at the mucosal surfaces. Basic insights gained from studying the natural immune protective mechanisms help propel better vaccine designs. On the other hand, when the immune system fails to successfully deal with the pathogens, downstream consequences include the development of infectious diseases, autoimmunity, neurodegenerative diseases, and cancer. For specific projects being carried out in this laboratory, please click on the links below.
Medical Research Interests
Public Health Interests
Academic Achievements & Community Involvement
News & Links
News
- March 15, 2026Source: The New York Times (with Akiko Iwasaki)
Confidential Report Calls for Sweeping Changes to Track Covid Vaccine Harms
- March 06, 2026Source: TIME (with Akiko Iwasaki, PhD, and Ellen Foxman, MD, PhD)
Are We Close to a Universal Vaccine for Respiratory Illnesses?
- February 26, 2026Source: Everyday Health (with Akiko Iwasaki, PhD)
What Is Inflammation and How Can It Affect Your Health?
- February 24, 2026
Using Machine Learning to Develop Personalized Vaccines for Cancer
Get In Touch
Contacts
Immunobiology
PO Box 208011, 300 Cedar Street
New Haven, CT 06520
United States
Administrative Support
Locations
The Anlyan Center
Academic Office
300 Cedar Street, Ste Suite 655B
New Haven, CT 06519
The Anlyan Center
Lab
300 Cedar Street, Ste S630
New Haven, CT 06519
Appointments
203.785.7662
Events
Yale Only Akiko Iwasaki, PhD - Noah Wolcott Palm, PhD - Emilia Favuzzi, PhD - Shawn Ferguson, PhD - Le Zhang, PhD - David R. Martinez, PhD - Yifei Cai
Yale Only Craig M Crews, PhD - Andrew Goodman, PhD - Akiko Iwasaki, PhD - Armita Nourmohammad - Megan Levings - Douglas Melton