Siqi Zhang
Associate Research ScientistCards
About
Research
Publications
2025
Omega-3 Fatty Acid Intake and Oxylipin Production in Response to Short-Term Ambient Air Pollution Exposure in Healthy Adults
Chen H, Zhang S, Pan X, Schneider A, Diaz-Sanchez D, Samet J, Tong H. Omega-3 Fatty Acid Intake and Oxylipin Production in Response to Short-Term Ambient Air Pollution Exposure in Healthy Adults. Toxics 2025, 13: 1063. PMID: 41441285, PMCID: PMC12737357, DOI: 10.3390/toxics13121063.Peer-Reviewed Original ResearchExposure to PM2.5Short-term air pollution exposureAir pollution exposurePollution exposureAir pollutionAmbient air pollution exposureExposure to air pollutionMixed-effects modelsPollutionN-3 FA groupElevated levelsPlasma concentrationsExposureParticipants' plasma samplesN-3 groupFA groupSpeciesHealthy adultsAssociated with systemic inflammationPro-inflammatory oxylipinsN-3Fatty acid intakeFatty acidsShort-Term Exposure to Low and High Temperatures and Mortality Among Patients With Heart Failure in Sweden
Ni W, Benson L, Ljungman P, Nobile F, Breitner S, Zhang S, de Bont J, Lund L, Savarese G, Schneider A, Agewall S. Short-Term Exposure to Low and High Temperatures and Mortality Among Patients With Heart Failure in Sweden. JAMA Cardiology 2025, 10: 1276-1284. PMID: 41123904, PMCID: PMC12547678, DOI: 10.1001/jamacardio.2025.3932.Peer-Reviewed Original ResearchConceptsCase-crossover studyAll-CauseOdds ratioCardiovascular mortalityCause of Death RegisterRisk of all-causeSwedish National Patient RegisterNational Patient RegisterAll-Cause MortalityStudy periodComorbid atrial fibrillationDeath RegisterAssociated with mortalityPatient RegisterMain OutcomesComorbid diabetesExposure to ambient temperatureDiuretic usersHeart failurePrimary outcomeSwedish patientsMortalityShort-term exposureAssociationRegisterImprovements in life expectancy mask rising trends in heat-related excess mortality attributable to climate change
Huber V, Breitner-Busch S, Feldbusch H, Frieler K, He C, Matthies-Wiesler F, Mengel M, Zhang S, Peters A, Schneider A. Improvements in life expectancy mask rising trends in heat-related excess mortality attributable to climate change. Nature Communications 2025 PMID: 41298519, DOI: 10.1038/s41467-025-66681-0.Peer-Reviewed Original ResearchExcess mortalityLife expectancyTemperature-mortality associationsAssociated with improvementsHealth outcomesClimate changeDeath burdenAttribution studiesHuman health outcomesTemporal trendsStudy periodNon-climatic driversReanalysis seriesAnthropogenic fingerprintSummer warmingTemperature dataMortalityLifeDoes personalization in exposure assessment change ambient air pollution exposure-response relationships? A panel study
Pulczinski J, Zhang S, Breen M, Breen M, Isakov V, Schneider A, Rappold A, Diaz-Sanchez D, Devlin R, Samet J, Tong H. Does personalization in exposure assessment change ambient air pollution exposure-response relationships? A panel study. Ecotoxicology And Environmental Safety 2025, 307: 119422. PMID: 41260034, DOI: 10.1016/j.ecoenv.2025.119422.Peer-Reviewed Original ResearchConceptsAir quality monitoringAmbient air pollutionAir pollutionExposure-response relationshipAccurate exposure assessmentLag0Exposure modelExposure assessmentCardiopulmonary biomarkersQuality monitoringPollutionMixed-effects modelsExposureLag4Lag1Cardiopulmonary diseaseNegative associationConcentrationPositive associationAirAssociations of Long-Term Exposure to Temperature Variability with Glucose Metabolism: Results from KORA F4 and FF4
Ni W, Zhang S, Herder C, Breitner-Busch S, Wolf K, Liao M, Nikolaou N, Pickford R, Koenig W, Rathmann W, Schwettmann L, Roden M, Thorand B, Peters A, Schneider A. Associations of Long-Term Exposure to Temperature Variability with Glucose Metabolism: Results from KORA F4 and FF4. Environmental Science And Technology 2025, 59: 24246-24256. PMID: 41200836, PMCID: PMC12631984, DOI: 10.1021/acs.est.5c04956.Peer-Reviewed Original ResearchConceptsKORA F4Homeostasis model assessmentQuantitative insulin sensitivity check indexAssociated with higher fasting insulinPopulation-based cohortExposure to temperature variabilityGlucose metabolismAssessment of B-cell functionGeneralized Estimating EquationsFasting insulinGlucose metabolism biomarkersGlobal diabetes epidemicHigher fasting insulinTemperature variabilityDiabetes prevalenceDiabetes epidemicLongitudinal associationsHealth remainsHOMA-IRFasting GlucoseModel assessment of insulin resistanceAssessment of insulin resistanceHomeostasis model assessment of insulin resistanceMetabolismInsulin sensitivity check indexLong-term exposure to traffic-related air pollution is associated with epigenetic age acceleration
Yao Y, Wolf K, Breitner S, Zhang S, Waldenberger M, Winkelmann J, Schneider A, Peters A. Long-term exposure to traffic-related air pollution is associated with epigenetic age acceleration. Environmental Research 2025, 288: 123284. PMID: 41202959, DOI: 10.1016/j.envres.2025.123284.Peer-Reviewed Original ResearchConceptsAnnual average concentrationsTraffic-related air pollutionExposure to traffic-related air pollutionLong-term exposure to traffic-related air pollutionAir pollutionParticulate matterEpigenetic ageing biomarkersAverage concentrations of ultrafine particlesLong-term exposure to air pollutionLand-use regression modelsExposure to air pollutionConcentrations of ultrafine particlesAir pollution exposureEpigenetic age accelerationAge accelerationPopulation-based Cooperative Health ResearchPollution exposureNegative impactEpigenome-wide association studiesPollutionCooperative Health ResearchRegion of AugsburgLinear mixed-effects regression modelsS4 surveyCoarse particlesShort-term association between ambient air pollution and heart rate variability: results from the population-based KORA S4 and FF4 studies
Li Y, Breitner-Busch S, Cascio W, Zhang S, Wolf K, Rückert-Eheberg I, Kääb S, Schmidt G, Strom A, Peters A, Schneider A. Short-term association between ambient air pollution and heart rate variability: results from the population-based KORA S4 and FF4 studies. Particle And Fibre Toxicology 2025, 22: 26. PMID: 41107970, PMCID: PMC12534996, DOI: 10.1186/s12989-025-00645-6.Peer-Reviewed Original ResearchConceptsGeneralized Additive Mixed ModelsGeneralized additive modelAir pollutionShort-term effectsShort-term effects of air pollutionEffects of ambient PM2.5Effects of air pollutionBackgroundAmbient air pollutionAir quality standardsExposure to PM2.5Low pollution levelsAmbient air pollutionAir pollution dataAdditive mixed modelsShort-term associationsKORA S4Low ambient concentrationsKORA FF4Heart rate variabilityAmbient PM2.5Pollution levelsIQR increaseAmbient concentrationsPollution dataMonitoring stationsWhat Are the Costs of Heat Spell Mortality in Europe’s Urban Areas up to 2050?
Andersen M, Aunan K, Christensen J, Im U, Stafoggia M, Suhrcke M, Ye Z, Zafeiratou S, Zhang S. What Are the Costs of Heat Spell Mortality in Europe’s Urban Areas up to 2050? Weather Climate And Society 2025, 17: 1043-1059. DOI: 10.1175/wcas-d-25-0026.1.Peer-Reviewed Original ResearchGlobal warmingHeat wave yearHeat spellsHealth impacts of heatUrban areasAir Quality DirectiveAir pollutionAir quality improvementAmbient Air Quality DirectiveSocial cost of carbonSummer temperaturesHeat-related deathsCost of carbonQuality DirectiveExposure-response functionsSocial costsClimatic gradientWarmingSoutheastern EuropeClimateDegree-daysEconomic valuationSignificant health impactsImpact of heatPremature mortalityShort-term effects of ultrafine particles on stroke events: an assessment using four different exposure metrics
Liao M, Zhang S, Schwarz M, He C, Breitner-Busch S, Cyrys J, Naumann M, Braadt L, Traidl-Hoffmann C, Hammel G, Peters A, Ertl M, Schneider A. Short-term effects of ultrafine particles on stroke events: an assessment using four different exposure metrics. Environment International 2025, 204: 109823. PMID: 41033071, DOI: 10.1016/j.envint.2025.109823.Peer-Reviewed Original ResearchConceptsEffects of ultrafine particlesUltrafine particle metricsUltrafine particlesImpact of traffic-related air pollutionShort-term effects of ultrafine particlesTraffic-related air pollutionHealth impactsMonitoring of ultrafine particlesInterquartile range increaseShort-term effectsShort-term exposureCumulative effectPolluted areasMonitoring sitesStroke eventsAir pollutionCase-crossover studyRange increaseElevated riskSize fractionsRisk of stroke eventsSurface area concentrationConditional logistic regressionExposure metricsAssociated with strokeShort-term exposure to ambient temperature variability and myocardial infarction hospital admissions: A nationwide case-crossover study in Sweden
Ni W, Stafoggia M, Zhang S, Ljungman P, Breitner S, de Bont J, Jernberg T, Atar D, Schneider A, Agewall S. Short-term exposure to ambient temperature variability and myocardial infarction hospital admissions: A nationwide case-crossover study in Sweden. PLOS Medicine 2025, 22: e1004607. PMID: 40392899, PMCID: PMC12091774, DOI: 10.1371/journal.pmed.1004607.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionNon-ST-segment elevation myocardial infarctionAssociated with increased riskHospital admissionAssociated with increased risk of hospital admissionElevation myocardial infarctionHospitalization riskRisk of hospital admissionConditional logistic regression modelsPopulation-based nationwide studyMyocardial infarctionShift exposureCase-crossover designPotential effect modifiersCase-crossover studyAssociated with decreased riskPatient's residential areaTemperature variabilityLogistic regression modelsNo significant associationHistory of diseaseTime-stratifiedMI hospitalizationSWEDEHEART registryClimate change
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