Douglas Brackney
Professor Adjunct of Epidemiology (Microbial Diseases)About
Research
Publications
2025
Cellular and molecular keys to entry: Mechanisms mediating Orthoflavivirus infection of the mosquito midgut
Nattoh G, Armstrong P, Brackney D. Cellular and molecular keys to entry: Mechanisms mediating Orthoflavivirus infection of the mosquito midgut. PLOS Pathogens 2025, 21: e1013617. PMID: 41144442, PMCID: PMC12558446, DOI: 10.1371/journal.ppat.1013617.Peer-Reviewed Original ResearchImplications of successive blood feeding on Wolbachia-mediated dengue virus inhibition in Aedes aegypti mosquitoes
Johnson R, Breban M, Nolan B, Sodeinde A, Ott I, Ross P, Gu X, Grubaugh N, Perkins T, Brackney D, Vogels C. Implications of successive blood feeding on Wolbachia-mediated dengue virus inhibition in Aedes aegypti mosquitoes. Nature Communications 2025, 16: 6971. PMID: 40730791, PMCID: PMC12307751, DOI: 10.1038/s41467-025-62352-2.Peer-Reviewed Original ResearchMosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti
Hall D, Johnson R, Kwon H, Ferdous Z, Laredo-Tiscareño S, Blitvich B, Brackney D, Smith R. Mosquito immune cells enhance dengue and Zika virus infection in Aedes aegypti. Nature Communications 2025, 16: 5891. PMID: 40593674, PMCID: PMC12214649, DOI: 10.1038/s41467-025-61139-9.Peer-Reviewed Original ResearchUsing geospatial analysis to describe the association between active tick surveillance data and clinical cases of anaplasmosis in Connecticut
Desiato J, Chan G, Palmeri M, Cantoni J, Cozens D, Linske M, Brackney D, Stafford K, Banach D. Using geospatial analysis to describe the association between active tick surveillance data and clinical cases of anaplasmosis in Connecticut. Journal Of Medical Entomology 2025, 62: 1026-1031. PMID: 40341955, DOI: 10.1093/jme/tjaf055.Peer-Reviewed Original ResearchDepartment of Public HealthConnecticut Department of Public HealthCases of anaplasmosisClinical cases of anaplasmosisIncidence ratePublic healthSurveillance dataPublic health interventionsPotential associationI. scapularisHealth interventionsTick surveillance dataConnecticut Agricultural Experiment StationIdentified geographic areasAgricultural Experiment StationEvaluate potential associationsIxodes scapularis ticksBacterium Anaplasma phagocytophilumPrevalence dataActive tick surveillanceClinical casesQuesting I. scapularisSpearman rank correlationIncreased riskAnaplasma phagocytophilumFunctional connectivity for white-tailed deer drives the distribution of tick-borne pathogens in a highly urbanized setting
Lilly M, Davis M, Kross S, Konowal C, Gullery R, Lee S, Poulos K, Gregory N, Nagy C, Cozens D, Brackney D, del Pilar Fernandez M, Diuk-Wasser M. Functional connectivity for white-tailed deer drives the distribution of tick-borne pathogens in a highly urbanized setting. Landscape Ecology 2025, 40: 87. PMID: 40270782, PMCID: PMC12011924, DOI: 10.1007/s10980-025-02101-4.Peer-Reviewed Original Research
2024
MosAIC: An annotated collection of mosquito-associated bacteria with high-quality genome assemblies
Foo A, Brettell L, Nichols H, Students 2, Muñoz M, Lysne J, Dhokiya V, Hoque A, Brackney D, Caragata E, Hutchinson M, Jacobs-Lorena M, Lampe D, Martin E, Moro C, Povelones M, Short S, Steven B, Xu J, Paustian T, Rondon M, Hughes G, Coon K, Heinz E. MosAIC: An annotated collection of mosquito-associated bacteria with high-quality genome assemblies. PLOS Biology 2024, 22: e3002897. PMID: 39546548, PMCID: PMC11633956, DOI: 10.1371/journal.pbio.3002897.Peer-Reviewed Original ResearchMultiple bloodmeals enhance dissemination of arboviruses in three medically relevant mosquito genera
Ferdous Z, Dieme C, Sproch H, Kramer L, Ciota A, Brackney D, Armstrong P. Multiple bloodmeals enhance dissemination of arboviruses in three medically relevant mosquito genera. Parasites & Vectors 2024, 17: 432. PMID: 39427222, PMCID: PMC11490111, DOI: 10.1186/s13071-024-06531-y.Peer-Reviewed Original ResearchConceptsAedes aegyptiMidgut infection ratesMultiple bloodmealsVector competence of Aedes aegyptiVirus vectorsLaboratory vector competence studiesVector competence studiesMosquito generaFeeding regimenBiting midgesCulex quinquefasciatusPost-infectionOropouche virusWest Nile virusBloodmealVirus disseminationVector competenceEscape barrierFeeding behaviorDissemination of arbovirusesAedes albopictus mosquitoesAedes triseriatusAedesFemale mosquitoesNile virusThe West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional roles
Huston N, Tsao L, Brackney D, Pyle A. The West Nile virus genome harbors essential riboregulatory elements with conserved and host-specific functional roles. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 121: e2312080121. PMID: 38985757, PMCID: PMC11260092, DOI: 10.1073/pnas.2312080121.Peer-Reviewed Original ResearchConceptsWest Nile virus genomeWest Nile virusPositive-sense RNA virusesFunctional roleArthropod cell linesRiboregulatory elementsGenome foldingFlaviviral genomeRNA genomeIncreasing global threatVirus genomeGenomeRNA virusesStructural homologyHost-dependentSecondary structureLack of effective therapeuticsFunctional validationLocked nucleic acidStructural insightsRNA drugsCell linesArthropod-borneNucleic acidsAntisense locked nucleic acidInvestigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics
Johnson R, Stopard I, Byrne H, Armstrong P, Brackney D, Lambert B. Investigating the dose-dependency of the midgut escape barrier using a mechanistic model of within-mosquito dengue virus population dynamics. PLOS Pathogens 2024, 20: e1011975. PMID: 38557892, PMCID: PMC11008821, DOI: 10.1371/journal.ppat.1011975.Peer-Reviewed Original ResearchConceptsBasal lamina layersInfection dynamicsYellow fever virusEpidemics of severe diseaseMidgut escape barrierDengue virusVirus population dynamicsAmount of virusEstablishment of infectionDose-dependentlyMosquito feeding behaviorDEN virusesExtrinsic incubation periodFever virusMidgut epitheliumBlood feedingFeeding eventsMidgutViral infection dynamicsZika virusAedes aegyptiCourse of infectionEscape barrierAedes albopictusIncubation periodField Isolation and Laboratory Vector-Host Studies of Brazoran Virus (Peribunyaviridae: Orthobunyavirus) from Florida.
Armstrong P, Anderson J, Sharma R, Misencik M, Bransfield A, Vossbrinck C, Brackney D. Field Isolation and Laboratory Vector-Host Studies of Brazoran Virus (Peribunyaviridae: Orthobunyavirus) from Florida. American Journal Of Tropical Medicine And Hygiene 2024, 110: 968-970. PMID: 38531101, PMCID: PMC11066360, DOI: 10.4269/ajtmh.23-0799.Peer-Reviewed Original ResearchConceptsCulex quinquefasciatusMultiple mouse tissuesVector competenceDisseminated infectionNucleotide identityTexas isolatesL segmentField isolatesS segmentFlorida strainBlood mealMidgut infectionDisease signsMouse tissuesLaboratory trialsCulex erraticusIntradermal inoculationAedes aegyptiQuinquefasciatusCulex mosquitoesCulexIsolatesSouthern FloridaSuckling miceVirus transmission
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Epidemiology of Microbial Diseases
123 Huntington St
New Haven, CT 06511
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