Qing Lan, MD, PhD
Professor Adjunct, Environmental Health SciencesAbout
Research
Publications
2024
Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium
Kishida R, Yin X, Abe S, Rahman S, Saito E, Islam R, Lan Q, Blechter B, Rothman N, Sawada N, Tamakoshi A, Shu X, Hozawa A, Kanemura S, Kim J, Sugawara Y, Park S, Kweon S, Ahsan H, Boffetta P, Chia K, Matsuo K, Qiao Y, Zheng W, Inoue M, Kang D, Seow W. Association between family history with lung cancer incidence and mortality risk in the Asia Cohort Consortium. International Journal Of Cancer 2024 PMID: 39361428, DOI: 10.1002/ijc.35191.Peer-Reviewed Original ResearchFamily history of lung cancerAsia Cohort ConsortiumCohort ConsortiumLC incidenceSmoking statusFamily historyHazard ratioRisk of lung cancerIncreased risk of lung adenocarcinomaHistory of lung cancerConfidence intervalsLung cancer incidenceSignificant effect modificationEstimate hazard ratiosIncreased riskPopulation-based cohortCox proportional hazards regression modelsRisk of lung adenocarcinomaProspective cohort studyAssociated with increased riskLung cancerProportional hazards regression modelsEthnic groupsHazards regression modelsCancer incidenceContext-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes
Long E, Yin J, Shin J, Li Y, Li B, Kane A, Patel H, Sun X, Wang C, Luong T, Xia J, Han Y, Byun J, Zhang T, Zhao W, Landi M, Rothman N, Lan Q, Chang Y, Yu F, Amos C, Shi J, Lee J, Kim E, Choi J. Context-aware single-cell multiomics approach identifies cell-type-specific lung cancer susceptibility genes. Nature Communications 2024, 15: 7995. PMID: 39266564, PMCID: PMC11392933, DOI: 10.1038/s41467-024-52356-9.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesGenome-wide association study lociSusceptibility genesLung cancer susceptibility genesTranscription factor footprintsChromatin accessibility mapsCis-regulatory elementsRisk-associated variantsRare cell typesRegulate gene expressionCell typesCell type-specificCancer susceptibility genesCausal variantsAssociation studiesGene regulationGene functionMultiomics approachTarget genesLociGene expressionGenesType-specificHuman lung cellsCCREsSRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma
Chen H, Gao S, Wang P, Xie M, Zhang H, Fan Y, Nie E, Lan Q. SRBD1 Regulates the Cell Cycle, Apoptosis, and M2 Macrophage Polarization via the RPL11‐MDM2‐p53 Pathway in Glioma. Environmental Toxicology 2024 PMID: 39258423, DOI: 10.1002/tox.24396.Peer-Reviewed Original ResearchRNA-binding proteinsP53 signalingInhibits Mdm2-mediated p53 ubiquitinationMDM2-mediated p53 ubiquitinationRPL11-MDM2-p53 pathwayElevated p53 levelsRibosomal protein expressionBinding to MDM2Tumor-associated macrophagesP53 signaling pathwayInactivation of p53P53 ubiquitinationRibosomal proteinsRNA translationM2 macrophage polarizationP53 levelsTumor growthRPL11Mouse xenograft modelEctopic expressionGlioma tumor growthCell cycleBinding proteinTarget genesSignaling pathwayOccupational exposure to benzene and risk of non‐Hodgkin lymphoma in an extended follow‐up of two population‐based prospective cohorts of Chinese men and women
Bassig B, Shu X, Friesen M, Vermeulen R, Purdue M, Ji B, Yang G, Wong J, Appel N, Hu W, Gao Y, Zheng W, Rothman N, Lan Q. Occupational exposure to benzene and risk of non‐Hodgkin lymphoma in an extended follow‐up of two population‐based prospective cohorts of Chinese men and women. International Journal Of Cancer 2024, 155: 2159-2168. PMID: 39221990, DOI: 10.1002/ijc.35095.Peer-Reviewed Original ResearchNon-Hodgkin's lymphomaRisk of non-Hodgkin lymphomaPopulation-based cohortCumulative exposurePopulation-based prospective cohortOccupational benzene exposurePooled analysisFollow-upAssociated with non-Hodgkin lymphomaChronic lymphocytic leukemia subtypesNon-Hodgkin lymphoma riskAssociated with NHL riskPopulation-based cohort of menLifetime cumulative exposureInternational Agency for Research on CancerCox proportional hazards modelsCumulative exposure estimatesCohort of menProportional hazards modelInconclusive associationsNHL riskExposure-response relationshipProspective cohortElevated riskSignificant exposure-responseInverse Probability Weighting to Estimate Impacts of Hypothetical Occupational Limits on Radon Exposure to Reduce Lung Cancer
Keil A, Li Y, Lan Q, Bertke S, Daniels R, Edwards J, Kelly-Reif K. Inverse Probability Weighting to Estimate Impacts of Hypothetical Occupational Limits on Radon Exposure to Reduce Lung Cancer. American Journal Of Epidemiology 2024, kwae299. PMID: 39168837, DOI: 10.1093/aje/kwae299.Peer-Reviewed Original ResearchHealthy worker survivor biasInverse probability weightingCumulative risk of lung cancerReduce lung cancer mortalitySurvivor biasRisk of lung cancerLung cancer mortalityReduce lung cancerRadon exposureProbability weightingWorking level monthsHealth effectsHealth outcomesCancer mortalityOccupational cohortOccupational limitsCumulative riskLung cancerHealthInverse probabilityUS Mine SafetyWorkersCancerAnnual standardEstimated impactEpigenome-wide association study of household air pollution exposure in an area with high lung cancer incidence.
Rahman M, Portengen L, Wong J, Breeze C, Blechter B, Hu W, Downward G, Zhang Y, Cardenas A, Ning B, Li J, Yang K, Hosgood H, Silverman D, Huang Y, Rothman N, Vermeulen R, Lan Q. Epigenome-wide association study of household air pollution exposure in an area with high lung cancer incidence. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1088.Peer-Reviewed Original ResearchHousehold air pollution and telomere length among women in Guatemala and Peru: the Household Air Pollution Intervention Network (HAPIN) trial
Salmons K, Keller K, Chang H, Chen Y, Jabbarzadeh S, Pillarisetti A, Young B, Steenland K, Mccracken J, Diaz Artiga A, Thompson L, Checkley W, Underhill L, Rothman N, Blechter B, Barr D, Peel J, Lan Q, Clark M. Household air pollution and telomere length among women in Guatemala and Peru: the Household Air Pollution Intervention Network (HAPIN) trial. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1581.Peer-Reviewed Original ResearchGene-environment interaction between exposure to smoky coal combustion and a polygenic risk score with the risk of lung cancer
Blechter B, Portengen L, Wang K, Wong J, Downward G, Hu W, Zhang Y, Rahman M, Hosgood H, Silverman D, Rothman N, Vermeulen R, Lan Q. Gene-environment interaction between exposure to smoky coal combustion and a polygenic risk score with the risk of lung cancer. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.0467.Peer-Reviewed Original ResearchEpigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai, China
Rahman M, Breeze C, Shu X, Wong J, Cardenas A, Wang X, Ji B, Hu W, Blechter B, Cai Q, Hosgood H, Yang G, Shi J, Long J, Gao Y, Bell D, Zheng W, Rothman N, Lan Q. Epigenome-wide association study of lung cancer among never-smokers in two prospective cohorts in Shanghai, China. ISEE Conference Abstracts 2024, 2024 DOI: 10.1289/isee.2024.1672.Peer-Reviewed Original ResearchExpanded PAH analysis of household air pollution in a rural region of China with high lung cancer incidence
Zhang Y, Meliefste K, Hu W, Portengen L, Rothman N, Reiss B, Li J, Xu J, Ning B, Liu D, Cassee F, Wong J, Vermeulen R, Lan Q, Downward G. Expanded PAH analysis of household air pollution in a rural region of China with high lung cancer incidence. Environmental Pollution 2024, 361: 124717. PMID: 39147225, DOI: 10.1016/j.envpol.2024.124717.Peer-Reviewed Original ResearchMethyl-PAHsHousehold air pollutionAir pollutionExposure assessmentReduce household air pollutionHuman carcinogenCoal combustion productsHighest lung cancer ratesDomestic combustionHigh lung cancer incidenceControlled burningStove typeStove ventilationHealth risksSmokeless coalRegions of ChinaStove useSuspected human carcinogensCoal sourcesFuel typeDriving factorsFuel transitionRural regions of ChinaSmoky coalPAHs