Viknesh Sounderajah
Assistant Professor AdjunctCards
About
Research
Publications
2026
Global analysis of country-level factors associated with chatbot usage for health
Schoenegger P, Costa-Gomes B, Tolmachev P, Wiedemann L, Liu X, Morgan D, Sounderajah V, Kelly C, Bhaskar M, King D, Suleyman M. Global analysis of country-level factors associated with chatbot usage for health. Nature Health 2026, 1-12. DOI: 10.1038/s44360-026-00174-2.Peer-Reviewed Original ResearchPublic use of a generalist LLM chatbot for health queries
Costa-Gomes B, Tolmachev P, Taysom E, Sounderajah V, Richardson H, Schoenegger P, Liu X, Nour M, Spielman S, Way S, Shah Y, Bhaskar M, Nori H, Kelly C, Hames P, Gross B, Suleyman M, King D. Public use of a generalist LLM chatbot for health queries. Nature Health 2026, 1: 689-696. DOI: 10.1038/s44360-026-00117-x.Peer-Reviewed Original Research
2025
Navigating life transitions and mental wellbeing in the digital age: a call for stakeholders to embrace innovation and collaboration
Fegert J, Gottschalk G, Schneider R, Sitarski E, Sounderajah V, Graham G. Navigating life transitions and mental wellbeing in the digital age: a call for stakeholders to embrace innovation and collaboration. Child And Adolescent Psychiatry And Mental Health 2025, 19: 67. PMID: 40517237, PMCID: PMC12166554, DOI: 10.1186/s13034-025-00932-2.Commentaries, Editorials and Letters
2024
Reported outcomes in studies of intermittent claudication - first step toward a core outcome set: systematic review
Shwan A, Lamidi S, Chan C, Daniels E, Song-Smith C, Hanna L, Sounderajah V, Houghton J, Sayers R. Reported outcomes in studies of intermittent claudication - first step toward a core outcome set: systematic review. BJS Open 2024, 8: zrae126. PMID: 39485886, PMCID: PMC11529788, DOI: 10.1093/bjsopen/zrae126.Peer-Reviewed Original ResearchDiagnostic performance of deep learning for infectious keratitis: a systematic review and meta-analysis
Ong Z, Sadek Y, Qureshi R, Liu S, Li T, Liu X, Takwoingi Y, Sounderajah V, Ashrafian H, Ting D, Mehta J, Rauz S, Said D, Dua H, Burton M, Ting D. Diagnostic performance of deep learning for infectious keratitis: a systematic review and meta-analysis. EClinicalMedicine 2024, 77: 102887. PMID: 39469534, PMCID: PMC11513659, DOI: 10.1016/j.eclinm.2024.102887.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statementsinfectious keratitisdiagnostic performancediagnostic accuracylow risksystematic reviewreference standardmeta-analysislow risk of biasrisk of biascorneal blindnessQUADAS-2microbiological resultsclinical registryexpert consensuskeratitisophthalmologistsmeta-analysesinternational validation studydeep learningcornealreviewvalidation studyRevised Tool for the Quality Assessment of Diagnostic Accuracy Studies Using AI (QUADAS-AI): Protocol for a Qualitative Study
Guni A, Sounderajah V, Whiting P, Bossuyt P, Darzi A, Ashrafian H. Revised Tool for the Quality Assessment of Diagnostic Accuracy Studies Using AI (QUADAS-AI): Protocol for a Qualitative Study. JMIR Research Protocols 2024, 13: e58202. PMID: 39293047, PMCID: PMC11447435, DOI: 10.2196/58202.Peer-Reviewed Original ResearchConceptsQuality Assessment of Diagnostic Accuracy StudiesINTERNATIONAL REGISTERED REPORT IDENTIFIERdiagnostic accuracy studiesaccuracy studiesmapping reviewquality assessment toolquality assessmentQUADAS-2risk of biasinternational expertscandidate itemsmethodological qualityitem generationqualitative studydissemination strategiesDelphi consensusDelphi panelconsensus meetingpublic involvementassessment toolEvaluating the diagnostic and triage performance of digital and online symptom checkers for the presentation of myocardial infarction; A retrospective cross-sectional study
Wallace W, Chan C, Chidambaram S, Hanna L, Acharya A, Daniels E, Normahani P, Matin R, Markar S, Sounderajah V, Liu X, Darzi A. Evaluating the diagnostic and triage performance of digital and online symptom checkers for the presentation of myocardial infarction; A retrospective cross-sectional study. PLOS Digital Health 2024, 3: e0000558. PMID: 39102377, PMCID: PMC11299816, DOI: 10.1371/journal.pdig.0000558.Peer-Reviewed Original Researchretrospective cross-sectional studycross-sectional studyatypical casesdiagnostic performanceonline symptom checkersMI patientssymptom checkersMI casesconsecutive MI patientslife-threatening conditionpresentation of myocardial infarctionatypical symptomsclinical datadiagnostic sensitivitytreatment recommendationsunder-diagnosedmyocardial infarctionpatientsprimary diagnosisclinical performancesymptomsInformation is a determinant of health
Graham G, Goren N, Sounderajah V, DeSalvo K. Information is a determinant of health. Nature Medicine 2024, 30: 927-928. PMID: 38351186, DOI: 10.1038/s41591-023-02792-9.Commentaries, Editorials and LettersAn introduction to digital determinants of health
Chidambaram S, Jain B, Jain U, Mwavu R, Baru R, Thomas B, Greaves F, Jayakumar S, Jain P, Rojo M, Battaglino M, Meara J, Sounderajah V, Celi L, Darzi A. An introduction to digital determinants of health. PLOS Digital Health 2024, 3: e0000346. PMID: 38175828, PMCID: PMC10766177, DOI: 10.1371/journal.pdig.0000346.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statementssocial determinants of healthdeterminants of healthdigital health literacysocial determinantsdigital health systemshealth literacydelivery of serviceshealth disparitieshealthcare outcomeshealth outcomeshealth systemmobile phone applicationhealthartificial intelligence systemshealthcaresocietal levelintelligent systemsphone applicationdigital technologiesoutcomesdigital dividetelemedicine
2023
Cardiovascular Health Equity for Survivors of Childhood Cancer Understanding the Drivers of Cardiovascular Risk ∗
Graham G, Sounderajah V, Johnson M. Cardiovascular Health Equity for Survivors of Childhood Cancer Understanding the Drivers of Cardiovascular Risk ∗. JACC CardioOncology 2023, 5: 501-503. PMID: 37614578, PMCID: PMC10443103, DOI: 10.1016/j.jaccao.2023.05.010.Commentaries, Editorials and Letters