EMD Seminar Series: Jue Tao Lim - “Wolbachia-Mediated Sterility for Dengue Suppression”

Incompatible insect technique (IIT) coupled with sterile insect technique (SIT) via the release of sterile male Wolbachia-infected mosquitoes is a promising tool for Aedes-borne disease control. Yet, real-world evidence on the suppressive effectiveness and efficacy of IIT-SIT remains limited to small scale studies over short durations. However, Aedes-borne diseases occur in dense, urban, and high-rise locations and sustain multi-year transmission cycles. To address evidence gaps, large-scale trials of IIT-SIT covering >1 million individuals to evaluate the epidemiological and entomological efficacy of IIT-SIT were conducted. I will present the development, application, key difficulties and results of these trials over the past decade.

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