2023
Interrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease
Ghosh S, Baker L, Chen F, Khera Z, Vain A, Zhang K, Hood A, Smith H, Chen H, Jagasia M, Tkaczyk E. Interrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease. Archives Of Dermatological Research 2023, 315: 2545-2554. PMID: 37227518, DOI: 10.1007/s00403-023-02626-1.Peer-Reviewed Original ResearchConceptsSkin sclerosisChronic graftHost diseaseAnatomic sitesAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationSclerotic chronic graftLong-term survivorsStem cell transplantationConfidence intervalsCGVHD treatmentSclerotic cGvHDSevere complicationsSkin scoreCurrent gold standardCell transplantationTherapeutic responseClinical reproducibilityCGVHDDorsal forearmMyotonSclerosisVolar forearmHealthy participantsMean pairwise differenceHyperspectral imaging to accurately segment skin erythema and hyperpigmentation in cutaneous chronic graft‐versus‐host disease
Saknite I, Kwun S, Zhang K, Hood A, Chen F, Kangas L, Kortteisto P, Kukkonen A, Spigulis J, Tkaczyk E. Hyperspectral imaging to accurately segment skin erythema and hyperpigmentation in cutaneous chronic graft‐versus‐host disease. Journal Of Biophotonics 2023, 16: e202300009. PMID: 36942511, DOI: 10.1002/jbio.202300009.Peer-Reviewed Original ResearchEnhanced characterization of breast cancer phenotypes using Raman micro-spectroscopy on stainless steel substrate
Thomas G, Fitzgerald S, Gautam R, Chen F, Haugen E, Rasiah P, Adams W, Mahadevan-Jansen A. Enhanced characterization of breast cancer phenotypes using Raman micro-spectroscopy on stainless steel substrate. Analytical Methods 2023, 15: 1188-1205. PMID: 36799369, DOI: 10.1039/d2ay01764d.Peer-Reviewed Original ResearchConceptsStainless steel substratesStainless steelSteel substrateRaman spectroscopySteelRaman signalRaman signal intensityCalcium fluoride substratesLaser powerFluoride substratesSignal qualityFundamental understandingStrong Raman signalNoise ratioSubstrateCost-effective alternativeEnhanced characterizationRaman spectraSignals
2022
Artificial intelligence recognition of cutaneous chronic graft‐versus‐host disease by a deep learning neural network
McNeil A, Parks K, Liu X, Saknite I, Chen F, Reasat T, Cronin A, Wheless L, Dawant B, Tkaczyk E. Artificial intelligence recognition of cutaneous chronic graft‐versus‐host disease by a deep learning neural network. British Journal Of Haematology 2022, 197: e69-e72. PMID: 35322873, PMCID: PMC9197858, DOI: 10.1111/bjh.18141.Peer-Reviewed Original Research
2020
Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease
Baker LX, Chen F, Ssempijja Y, Byrne M, Kim TK, Vain A, Jagasia M, Tkaczyk ER. Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease. Bone Marrow Transplantation 2020, 56: 989-991. PMID: 33279941, PMCID: PMC8117134, DOI: 10.1038/s41409-020-01158-w.Peer-Reviewed Original Research
2019
Crowdsourcing to delineate skin affected by chronic graft‐vs‐host disease
Tkaczyk E, Coco J, Wang J, Chen F, Ye C, Jagasia M, Dawant B, Fabbri D. Crowdsourcing to delineate skin affected by chronic graft‐vs‐host disease. Skin Research And Technology 2019, 25: 572-577. PMID: 30786065, PMCID: PMC6719554, DOI: 10.1111/srt.12688.Peer-Reviewed Original ResearchConceptsChronic graftHost diseaseAffected skinPercent body surface areaBody surface areaBoard-certified dermatologistsCurrent clinical standardMedian Dice indexCGVHD patientsPrimary outcomeImportant unmetAffected surface areaThree-dimensional photographsClinical standardsFleiss' kappaDiseaseSkinGraftPractical managementWeak correlationHigh agreementKappaConsensus delineationPatients
2018
Reproducibility of the durometer and myoton devices for skin stiffness measurement in healthy subjects
Dellalana L, Chen F, Vain A, Gandelman J, Põldemaa M, Chen H, Tkaczyk E. Reproducibility of the durometer and myoton devices for skin stiffness measurement in healthy subjects. Skin Research And Technology 2018, 25: 289-293. PMID: 30414198, PMCID: PMC6546306, DOI: 10.1111/srt.12646.Peer-Reviewed Original ResearchConceptsInterobserver intraclass correlation coefficientOverall stiffnessIntraclass correlation coefficientHealthy subjectsMinimal detectable changeSkin stiffness measurementsDisease progressionMyotonClinical assessmentTreatment efficacyDorsal forearmUpper armVolar forearmIndustrial devicesMeasure of reproducibilityBiomechanical parametersStiffness measurementSingle observerStiffness parametersSkin stiffnessDetectable changeFurther investigationForearmStiffnessCoefficient of variationNon-invasive measurement of sclerosis in cutaneous cGVHD patients with the handheld device Myoton: a cross-sectional study
Chen F, Dellalana L, Gandelman J, Vain A, Jagasia M, Tkaczyk E. Non-invasive measurement of sclerosis in cutaneous cGVHD patients with the handheld device Myoton: a cross-sectional study. Bone Marrow Transplantation 2018, 54: 616-619. PMID: 30287938, PMCID: PMC6872187, DOI: 10.1038/s41409-018-0346-7.Peer-Reviewed Original ResearchOvercoming human disagreement assessing erythematous lesion severity on 3D photos of chronic graft-versus-host disease
Tkaczyk E, Chen F, Wang J, Gandelman J, Saknite I, Dellalana L, Jagasia M, Dawant B. Overcoming human disagreement assessing erythematous lesion severity on 3D photos of chronic graft-versus-host disease. Bone Marrow Transplantation 2018, 53: 1356-1358. PMID: 29740182, PMCID: PMC6858843, DOI: 10.1038/s41409-018-0211-8.Peer-Reviewed Original Research