2024
Pan-pathogen deep sequencing of nosocomial bacterial pathogens in Italy in spring 2020: a prospective cohort study
Thorpe H, Pesonen M, Corbella M, Pesonen H, Gaiarsa S, Boinett C, Tonkin-Hill G, Mäklin T, Pöntinen A, MacAlasdair N, Gladstone R, Arredondo-Alonso S, Kallonen T, Jamrozy D, Lo S, Chaguza C, Blackwell G, Honkela A, Schürch A, Willems R, Merla C, Petazzoni G, Feil E, Cambieri P, Thomson N, Bentley S, Sassera D, Corander J. Pan-pathogen deep sequencing of nosocomial bacterial pathogens in Italy in spring 2020: a prospective cohort study. The Lancet Microbe 2024, 100890. PMID: 39178869, DOI: 10.1016/s2666-5247(24)00113-7.Peer-Reviewed Original ResearchIntensive care unitProspective cohort studyCohort studyHospital transmissionWhole-genome sequencingCare unitDeep sequencing approachSingle nucleotide polymorphism distancesNosocomial bacterial pathogensInfection control measuresAntimicrobial resistance genesPathogenic speciesBacterial pathogensDeep sequencingEffectiveness of infection control measuresAntimicrobial resistance genes prevalenceAcinetobacter baumanniiNosocomial infectionsStreptococcus pneumoniaeSan Matteo HospitalClinical surveillanceWithin-patientKlebsiella pneumoniaeCo-colonisationGene prevalence
2022
A new perspective on ancient Mitis group streptococcal genetics
Belman S, Chaguza C, Kumar N, Lo S, Bentley SD. A new perspective on ancient Mitis group streptococcal genetics. Microbial Genomics 2022, 8: 000753. PMID: 35225216, PMCID: PMC8942026, DOI: 10.1099/mgen.0.000753.Peer-Reviewed Original ResearchConceptsCommensal speciesVirulence factorsPathogenic speciesSpecific virulence factorsMitis groupHost-microbe interactionsMajor virulence factorInvasive diseaseLeading causeOral cavityVaccine antigensEvolutionary divergenceExtant speciesEvolutionary historyExtant strainsStreptococcus pneumoniaeSuch genesAncient genomesSynthesis genesGene databaseIndividual speciesPolysaccharide capsuleZinc metalloproteasesStable maintenanceObligate bacteria