A new perspective on ancient Mitis group streptococcal genetics
Belman S, Chaguza C, Kumar N, Lo S, Bentley SD. A new perspective on ancient Mitis group streptococcal genetics. Microbial Genomics 2022, 8: 000753. PMID: 35225216, PMCID: PMC8942026, DOI: 10.1099/mgen.0.000753.Peer-Reviewed Original ResearchConceptsCommensal speciesVirulence factorsPathogenic speciesSpecific virulence factorsMitis groupHost-microbe interactionsMajor virulence factorInvasive diseaseLeading causeOral cavityVaccine antigensEvolutionary divergenceExtant speciesEvolutionary historyExtant strainsStreptococcus pneumoniaeSuch genesAncient genomesSynthesis genesGene databaseIndividual speciesPolysaccharide capsuleZinc metalloproteasesStable maintenanceObligate bacteria