2018
Giant tortoise genomes provide insights into longevity and age-related disease
Quesada V, Freitas-Rodríguez S, Miller J, Pérez-Silva J, Jiang Z, Tapia W, Santiago-Fernández O, Campos-Iglesias D, Kuderna L, Quinzin M, Álvarez M, Carrero D, Beheregaray L, Gibbs J, Chiari Y, Glaberman S, Ciofi C, Araujo-Voces M, Mayoral P, Arango J, Tamargo-Gómez I, Roiz-Valle D, Pascual-Torner M, Evans B, Edwards D, Garrick R, Russello M, Poulakakis N, Gaughran S, Rueda D, Bretones G, Marquès-Bonet T, White K, Caccone A, López-Otín C. Giant tortoise genomes provide insights into longevity and age-related disease. Nature Ecology & Evolution 2018, 3: 87-95. PMID: 30510174, PMCID: PMC6314442, DOI: 10.1038/s41559-018-0733-x.Peer-Reviewed Original ResearchConceptsGiant tortoisesAge-related diseasesNew genome sequencesAldabra giant tortoiseDNA repair genesGiant tortoise populationLonesome GeorgeRelated speciesGenome sequenceEvolutionary informationVertebrate animalsGenomic determinantsTortoise populationsGenomeExcellent modelRepair genesCancer developmentTortoisesSupervised analysisGenesEvolutionary strategyGlobal analysisImportant resourceLast memberLongevity
2013
The genetic legacy of Lonesome George survives: Giant tortoises with Pinta Island ancestry identified in Galápagos
Edwards D, Benavides E, Garrick R, Gibbs J, Russello M, Dion K, Hyseni C, Flanagan J, Tapia W, Caccone A. The genetic legacy of Lonesome George survives: Giant tortoises with Pinta Island ancestry identified in Galápagos. Biological Conservation 2013, 157: 225-228. DOI: 10.1016/j.biocon.2012.10.014.Peer-Reviewed Original ResearchLonesome GeorgeGiant tortoise speciesFirst-generation hybridsPurebred individualsAdditional hybridsPinta IslandGeneration hybridsGenetic legacyTortoise speciesGiant tortoisesSpecies recoveryGalápagos ArchipelagoRelative abundanceIsabela IslandTortoisesUnrelated individualsAdditional individualsAncestryHybridsIslands
2007
Lineage identification of Galápagos tortoises in captivity worldwide
Russello M, Hyseni C, Gibbs J, Cruz S, Marquez C, Tapia W, Velensky P, Powell J, Caccone A. Lineage identification of Galápagos tortoises in captivity worldwide. Animal Conservation 2007, 10: 304-311. DOI: 10.1111/j.1469-1795.2007.00113.x.Peer-Reviewed Original ResearchMitochondrial DNA control region sequencesGenetic dataPopulation allele frequency dataCaptive population managementControl region sequencesMicrosatellite genotype dataPopulation genetic dataConservation valueConservation strategiesLonesome GeorgeCaptive breedingExtant populationsAllele frequency dataMtDNA haplotypesRobust populationEvolutionary originGalápagos tortoisesHybrid originPopulation managementMuseum specimensMtDNA analysisGeochelone nigraRegion sequencesMolecular approachesNovel haplotypes
2003
The origin of captive Galápagos tortoises based on DNA analysis: implications for the management of natural populations
Burns C, Ciofi C, Beheregaray L, Fritts T, Gibbs J, Márquez C, Milinkovitch M, Powell J, Caccone A. The origin of captive Galápagos tortoises based on DNA analysis: implications for the management of natural populations. Animal Conservation 2003, 6: 329-337. DOI: 10.1017/s1367943003003408.Peer-Reviewed Original ResearchNatural populationsMtDNA haplotypesCaptive individualsMtDNA control region haplotypesDistinct mtDNA haplotypesControl region haplotypesMultilocus microsatellite genotypesCaptive breeding programsSpecies management plansNumber of breedersLonesome GeorgeCharles Darwin Research StationCR haplotypesEvolutionary originGalápagos tortoisesIsland populationsMicrosatellite genotypesRegion haplotypesGiant tortoisesGalápagos IslandsGalápagos ArchipelagoGeographic originMolecular techniquesHaplotypesCaptive tortoises
1999
Origin and evolutionary relationships of giant Galápagos tortoises
Caccone A, Gibbs J, Ketmaier V, Suatoni E, Powell J. Origin and evolutionary relationships of giant Galápagos tortoises. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 13223-13228. PMID: 10557302, PMCID: PMC23929, DOI: 10.1073/pnas.96.23.13223.Peer-Reviewed Original ResearchGiant Galápagos tortoisesLonesome GeorgeGalápagos tortoisesDistinct genetic unitsMitochondrial DNA sequencesMainland South AmericaSouth AmericaEvolutionary relationshipsPhylogenetic reconstructionSeparate colonizationsSouthern subspeciesPinta IslandChaco tortoisesDNA sequencesGalápagos IslandsClosest livingG. chilensisGenetic unitsSubspeciesCharles DarwinTortoisesLarge islandsSan CristobalChilensisLast survivor