Denise Esserman, PhD
Professor of BiostatisticsDownloadHi-Res Photo
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Professor of Biostatistics
Biography
Denise Esserman joined the Yale School of Public Health faculty in 2014 as an associate professor of biostatistics. She is interested in methods related to clustered randomized trials and the impact of the ICC and other factors on calculating sample size. As a member of the Yale Center for Analytical Sciences, she collaborates with a number of departments at the Yale School of Medicine, including the Clinical and Translational Science Award Program, Patient-Centered Outcomes Research Institute, and the Cancer Center. She has reviewed articles for the American Journal of Epidemiology, Arteriosclerosis, Thrombosis and Vascular Biology; Statistics in Biopharmaceutical Research; Clinical Trials; and Obesity. Esserman earned her doctorate at Columbia University and has since taught at the University of North Carolina, Chapel Hill.
Last Updated on April 07, 2025.
Appointments
Biostatistics
ProfessorPrimary
Other Departments & Organizations
Education & Training
- PhD
- Columbia University (2006)
- MS
- University of Georgia (2001)
Research
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Overview
Medical Research Interests
Biostatistics; Longitudinal Studies; Public Health; Randomized Controlled Trial; Sampling Studies
ORCID
0000-0003-1326-9618
Research at a Glance
Yale Co-Authors
Frequent collaborators of Denise Esserman's published research.
Publications Timeline
A big-picture view of Denise Esserman's research output by year.
Research Interests
Research topics Denise Esserman is interested in exploring.
Fan Li, PhD
Erich J Greene, PhD
David Ganz
Frederick Lewis Altice, MD, MA
Leah Ferrucci, PhD, MPH
Melinda Irwin, PhD, MPH
53Publications
1,397Citations
Longitudinal Studies
Publications
2025
Fall Risk in Maintenance Hemodialysis Patients
Charytan D, Moss A, Shalak M, Wu W, Dember L, Hsu J, Kuzla N, Esserman D, Kalim S, Kimmel P, Lockwood M, Miyawaki N, Pellegrino B, Pun P, Qamhiyeh R, Scherer J, Schrauben S, Weiner D, Mehrotra R. Fall Risk in Maintenance Hemodialysis Patients. Clinical Journal Of The American Society Of Nephrology 2025, 20: 1247-1258. PMID: 40663732, PMCID: PMC12445375, DOI: 10.2215/cjn.0000000775.Peer-Reviewed Original ResearchCitationsAltmetricConceptsFrequent cause of fallsFall riskCause of fallsPatient-reported symptomsMedication useParticipants' homesChronic painSeverity of pain symptomsOutcomes of fallsPain Coping SkillsDemographic characteristicsCognitive behavioral therapy interventionPain symptomsHemodialysis unitBehavioral therapy interventionUS dialysis facilitiesCohort of maintenance hemodialysis patientsMaintenance hemodialysis patientsUsual careTherapy interventionsBackground FallsNo significant associationParticipants' yearsFrequent causeCoping skillsPower calculation for cross-sectional stepped wedge cluster randomized trials with a time-to-event endpoint
Baumann M, Esserman D, Taljaard M, Li F. Power calculation for cross-sectional stepped wedge cluster randomized trials with a time-to-event endpoint. Biometrics 2025, 81: ujaf074. PMID: 40557765, PMCID: PMC12188223, DOI: 10.1093/biomtc/ujaf074.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsSW-CRTsCluster randomized trialStepped wedge cluster randomized trialTime-to-event endpointsTime-to-event outcomesRobust sandwich varianceMarginal Cox modelSandwich varianceWithin-periodElectronic reminder systemSW-CRTRandomized trialsBinary outcomesPower calculationsPower formulaReminder systemR Shiny applicationHospital settingCorrelation parametersSample sizePlanned trialsCox modelWaldFormulaTrialsRandomised controlled trial of LGBTQ-affirmative cognitive-behavioural therapy for sexual minority women’s minority stress, mental health and hazardous drinking: Project EQuIP protocol
Pachankis J, Chiaramonte D, Scheer J, Ankrum H, Eisenstadt B, Hobbs R, Baldwin H, Kidd J, Witkiewitz K, Esserman D, Plourde K, Drabble L, Hughes T. Randomised controlled trial of LGBTQ-affirmative cognitive-behavioural therapy for sexual minority women’s minority stress, mental health and hazardous drinking: Project EQuIP protocol. BMJ Open 2025, 15: e086738. PMID: 40032395, PMCID: PMC11877267, DOI: 10.1136/bmjopen-2024-086738.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsCognitive-behavioral therapy interventionSexual minority womenMinority womenHazardous drinkingMinority stressRandomised controlled trialsProportion of heavy drinking daysSessions of supportive counselingComorbid mental health problemsRisk of hazardous drinkingCognitive-behavioral therapyHeavy drinking daysHazardous alcohol useHuman Subjects CommitteeMental health comorbiditiesMental health problemsAnxiety disordersAnxious symptomsDrinking daysEvidence-based interventionsSupportive counselingControlled TrialsStress copingComorbid depression/anxietyDisproportionate riskEndpoint assessment via routinely collected data generates estimates comparable to randomized controlled trial data: analysis of a cluster-randomized trial on fall injury prevention
Ganz D, Greene E, Latham N, Kane M, Min L, Gill T, Reuben D, Peduzzi P, Esserman D. Endpoint assessment via routinely collected data generates estimates comparable to randomized controlled trial data: analysis of a cluster-randomized trial on fall injury prevention. Journal Of Clinical Epidemiology 2025, 181: 111718. PMID: 39938700, PMCID: PMC12103980, DOI: 10.1016/j.jclinepi.2025.111718.Peer-Reviewed Original ResearchAltmetricConceptsRatio of hazard ratiosHazard ratioConfidence intervalsDevelop Confidence in EldersEnhanced usual careFall injury riskPrimary care practicesFall injury preventionPrimary outcomeIncreasing length of follow-upCluster randomized trialUS healthcare systemStudy dataEstimates of validityUsual careInjury preventionCare practicesMultifactorial interventionOutcome ascertainmentInjury riskCluster-randomizedCare managementRandomized Controlled Trial DataStride dataHealthcare systemPain Coping Skills Training for Patients Receiving Hemodialysis
Dember L, Hsu J, Mehrotra R, Cavanaugh K, Kalim S, Charytan D, Fischer M, Jhamb M, Johansen K, Becker W, Pellegrino B, Eneanya N, Schrauben S, Pun P, Unruh M, Morasco B, Mehta M, Miyawaki N, Penfield J, Bernardo L, Brintz C, Cheatle M, Doorenbos A, Heapy A, Keefe F, Krebs E, Kuzla N, Nigwekar S, Schmidt R, Steel J, Wetmore J, White D, Kimmel P, Cukor D, Adams M, Almonte-Then S, Amonu C, Anderson L, Argega Leon A, Argyropoulos C, Ashley E, Bajana Meza M, Bansal N, Barbosa M, Barrell T, Bart G, Barton A, Beach S, Beeks L, Belcher J, Berman N, Berry D, Bhatraju E, Bishop N, Blazes C, Busch A, Cameron S, Cardona M, Casilli V, Cazes M, Chacon Palma G, Chalamidas K, Chaudry S, Chen N, Chicos I, Clark C, Collins D, Connelly L, Contreras B, Cosmin A, Crowley S, Dalton C, Dirks J, Donahue S, Dutka P, Dyer V, Edeh O, Edwards D, Edwards D, Ekor K, Esserman D, Falker C, Farkas L, Farrar J, Felson S, Flores Y, Fraticelli Ortiz D, Garcia G, Gear L, Geibel A, Gilmartin C, Goldfarb D, Goldfeld K, Goldstein A, Gong A, Grant C, Grindstaff R, Guajardo E, Guy C, Hamm M, Hammond J, Harris K, Hoffman S, Holden C, Howell H, Ikizler T, Joffe S, Joffe J, Johnson S, Kalam E, Kampman K, Keane C, Kimura G, Kirsch O, Kourany W, Krishnamurthy P, Kubrick P, Lacey P, Landis J, Lash J, Lazlo K, Lee J, Lefler J, Leon Cupe A, Lerner S, Liebschutz J, Lietz P, Linke L, Lockwood M, Luo H, Macina A, McCarthy A, McDaniels K, McLaren S, McNeil D, Meinel M, Mejia V, Mengesha B, Merriman D, Michael W, Mims R, Mishra P, Modersitzki F, Moss A, Mullins C, Munet U, O'Connell K, Okereke U, Olejniczak D, Opeke S, Pacheco-Hernandez M, Pankratz S, Park D, Payne K, Pegues H, Percy S, Pleasant S, Purdy T, Quinn D, Quintana N, Rice K, Robinson G, Roche C, Rodriguez Sosa G, Rudow G, Rudy Q, Rutledge J, Sanchez S, Sands B, Scherer J, Schopp M, Self B, Shallcross A, Silva K, Stallings T, Stauffer C, Steffen A, Stewart T, Stringfellow S, Sullivan L, Torres R, Torres J, Trejo G, Varela D, Vassilieva S, Vilchis H, Villareal D, Walsh J, Ways J, Weidner T, Weimer M, Weiner D, Weisbord S, Wilkie C, Wilkinson M, Williams S, Williams J, Wilson O, Wood V, Yabes J, Zamora G, Zaniga S. Pain Coping Skills Training for Patients Receiving Hemodialysis. JAMA Internal Medicine 2025, 185: 197-207. PMID: 39786400, PMCID: PMC11791705, DOI: 10.1001/jamainternmed.2024.7140.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPain Coping Skills TrainingPain coping skills training groupUsual care groupBrief Pain InventoryUsual carePain interferenceCoping skills trainingCare groupQuality of lifePain catastrophizingPain intensityBPI interferenceOutcomes of pain intensityRandomized clinical trialsSecondary outcomesChronic painSecondary outcomes of pain intensitySkills trainingBPI interference scoreCognitive behavioral interventionProportion of participantsOutpatient dialysis facilitiesClinically Meaningful ImprovementsPain interventionsRandomized clinical trial of patients
2024
Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine
Machavariani E, Bromberg D, Dumchev K, Esserman D, Earnshaw V, Pykalo I, Filippovich M, Ivasiy R, Ahmad B, Long J, Haddad M, Madden L, Oliveros D, Dvoriak S, Altice F. Decrease in provider stigma is associated with improved quality health indicators among individuals receiving methadone in primary care centers in Ukraine. International Journal Of Drug Policy 2024, 136: 104682. PMID: 39705875, PMCID: PMC11821433, DOI: 10.1016/j.drugpo.2024.104682.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsPrimary care centersQuality health indicatorsProvider stigmaEvidence-based practiceGuideline-concordantPatient outcomesHealth indicatorsReduce provider stigmaCare centerInfluence healthcare utilizationSpecialty health servicesPatient-level outcomesTele-educationImprove patient outcomesProvider fearsImplementation trialHealthcare utilizationPreventive careHealth servicesPoor healthLinear mixed-effects modelsImprove attitudesStigmaIncrease accessMixed-effects modelsBayesian pathway analysis over brain network mediators for survival data
Tian X, Li F, Shen L, Esserman D, Zhao Y. Bayesian pathway analysis over brain network mediators for survival data. Biometrics 2024, 80: ujae132. PMID: 39530270, PMCID: PMC11555425, DOI: 10.1093/biomtc/ujae132.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAccelerated failure time modelFailure time modelBrain connectivityAlzheimer's Disease Neuroimaging Initiative studyMaximum information extractionResponse regressionBayesian approachInformation extractionTime modelSurvival dataNoisy componentsUnique edgeWhite matter fiber tractsNetwork configurationBrain networksInterconnection networksNetworkNetwork mediatorsBrainChronic Pain Characteristics and Associated Symptoms in Patients on Maintenance Hemodialysis: Findings from the HOPE Consortium Trial
Fischer M, Hsu J, Walsh J, Charytan D, Crowley S, Cukor D, Dember L, Doorenbos A, Esserman D, Jhamb M, Johansen K, Keefe F, Kimmel P, Lockwood M, Mehrotra R, Morasco B, Nigwekar S, Pun P, Qamhiyeh R, Scherer J, Schmidt R, Steel J, Unruh M, Yabes J, Kalim S. Chronic Pain Characteristics and Associated Symptoms in Patients on Maintenance Hemodialysis: Findings from the HOPE Consortium Trial. Journal Of The American Society Of Nephrology 2024, 35: 10.1681/asn.2024pq91pf10. DOI: 10.1681/asn.2024pq91pf10.Peer-Reviewed Original ResearchDesign and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine
Machavariani E, Dumchev K, Pykalo I, Filippovych M, Ivasiy R, Esserman D, Madden L, Bromberg D, Haddad M, Morozova O, Ahmad B, Gómez D, Farnum S, Dvoriak S, Altice F. Design and implementation of a Type-2 hybrid, prospective randomized trial of opioid agonist therapies integration into primary care clinics in Ukraine. Contemporary Clinical Trials 2024, 146: 107690. PMID: 39265780, PMCID: PMC11531372, DOI: 10.1016/j.cct.2024.107690.Peer-Reviewed Original ResearchCitationsConceptsPrimary care centersQuality health indicatorsNon-communicable diseasesSpecialty treatment centersOpioid agonist therapyImplementation of integrated carePay-for-performance incentivesPrimary care clinicsPrimary care settingSelf-reported prevalencePay-for-performancePrevalence of medical comorbiditiesParticipants self-reportedEffective evidence-based treatmentsHealth of PWIDEvidence-based treatmentsIntegrated careCare clinicsImplementation outcomesImplementation trialCare settingsElectronic chart reviewHigh-burden countriesSpecialty servicesHIV prevalenceAssessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study
Esserman D, Greene E, Latham N, Kane M, Lu C, Peduzzi P, Gill T, Ganz D. Assessing readiness to use electronic health record data for outcome ascertainment in clinical trials – A case study. Contemporary Clinical Trials 2024, 142: 107572. PMID: 38740298, PMCID: PMC11654751, DOI: 10.1016/j.cct.2024.107572.Peer-Reviewed Original ResearchCitationsConceptsElectronic health record dataElectronic health recordsOutcome ascertainmentDevelop Confidence in EldersElectronic health record platformsClinical sitesPrimary care practicesHealth record dataMulti-site trialMulti-site clinical trialCare practicesHealth recordsAssess readinessAcute clinical outcomesHealthcare systemRecord dataClinical trialsReduce injuriesData qualityData comprehensionChecklistStudy dataClinical trial sitesVariable data qualityAscertainment
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