Heping Zhang, PhD
Susan Dwight Bliss Professor of Biostatistics, Professor in the Child Study Center and Professor of Statistics and Data Science, Professor of Obstetrics, Gynecology, and Reproductive SciencesDownloadHi-Res Photo
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Affiliated Faculty, Yale Institute for Global Health
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Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Contact Info
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
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Susan Dwight Bliss Professor of Biostatistics, Professor in the Child Study Center and Professor of Statistics and Data Science, Professor of Obstetrics, Gynecology, and Reproductive Sciences
Affiliated Faculty, Yale Institute for Global Health
Biography
Dr. Zhang published over 410 research articles and monographs in theory and applications of statistical methods and in several areas of biomedical research including epidemiology, genetics, child and women health, mental health, substance use, and reproductive medicine. He directed a training program in mental health research that was funded by the NIMH. He directs the Collaborative Center for Statistics in Science that coordinates the Reproductive Medicine Network to evaluate treatment effectiveness for infertility. He is a fellow of the American Statistical Association and a fellow of the Institute of Mathematical Statistics. He was named the 2008 Myrto Lefokopoulou distinguished lecturer by Harvard School of Public Health and a Medallion Award and Lecturer by the Institute of Mathematical Statistics. In 2011, he received the Royan International Award on Reproductive Health. Dr. Zhang was the president of the International Chinese Statistical Association in 2019. He is a former-editor of the Journal of the American Statistical Association - Applications and Case Studies. He was the recipient of the 2022 Neyman Award and Lecture by the Institute of Mathematical Statistics and the 2023 Distinguished Achievement Award by the International Chinese Statistical Association. He was selected as a 2023 Highly Cited Researcher in cross field by Web of Science.
Last Updated on October 14, 2025.
Appointments
Biostatistics
ProfessorPrimaryChild Study Center
ProfessorSecondaryStatistics
ProfessorSecondary
Other Departments & Organizations
- Big Data Summer Immersion at Yale
- Biostatistics
- Center for Brain & Mind Health
- Child Study Center
- Collaborative Center for Statistics in Science (C2S2)
- Computational Biology and Biomedical Informatics
- Global Health Studies
- High Performance Computation
- Public Health Data Science and Data Equity
- Statistics
- Stress & Addiction Clinical Research Program
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
- Yale Institute for Global Health
- Yale School of Public Health
- Yale Ventures
- YSPH Global Health Concentration
Education & Training
- Postdoctoral Fellow
- Mathematical Science Research Institute (1991)
- PhD
- Stanford University (1991)
Research
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Overview
- Analysis of Genomic Data for Complex Traits
- Data Coordination Center for Reproductive Medicine
- Clinical Trials for Infertility Treatments
Medical Research Interests
Biostatistics; Child Psychiatry; Computational Biology; Epidemiology; Genomics; Infertility; Mental Health; Pregnancy; Psychiatry; Statistics
Public Health Interests
Genetics, Genomics, Epigenetics; Epidemiology Methods; Clinical Trials; Maternal & Child Health; Modeling; Mental Health; COVID-19; Child/Adolescent Health; Reproduction
ORCID
0000-0002-0688-4076- View Lab Website
Collaborative Center for Statistics in Science
Research at a Glance
Yale Co-Authors
Frequent collaborators of Heping Zhang's published research.
Publications Timeline
A big-picture view of Heping Zhang's research output by year.
Research Interests
Research topics Heping Zhang is interested in exploring.
Fangbai (Janet) Sun, MPH
Hao Huang, MD, MPH
James Leckman, MD, PhD
Uma Reddy, MD, MPH
Hugh Taylor, MD
Xingguang Luo, MD
393Publications
21,648Citations
Pregnancy
Infertility
Computational Biology
Genomics
Publications
2025
A Relook at the Relevance of Thyroid Stimulating Hormone and Thyroid Autoimmunity for Pregnancy Outcomes: Analyses of Randomized Control Trials Data From Pregnancy and Polycystic Ovary Syndrome and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation
Kuokkanen S, Seungdamrong A, Santoro N, Lieman H, Sun F, Wild R, Zhang H, Pal L. A Relook at the Relevance of Thyroid Stimulating Hormone and Thyroid Autoimmunity for Pregnancy Outcomes: Analyses of Randomized Control Trials Data From Pregnancy and Polycystic Ovary Syndrome and Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation. Obstetrical & Gynecological Survey 2025, 80: 561-562. DOI: 10.1097/ogx.0000000000001445.Peer-Reviewed Original ResearchConceptsPreterm deliveryThyroid autoimmunityAssessment of Multiple Intrauterine GestationsAssociated with pregnancy complicationsLow birth weightThyroid-stimulating hormonePolycystic ovary syndromeIntrauterine gestationPregnancy complicationsPregnancy outcomesOvarian stimulationBirth weightStimulating hormonePregnancy lossPregnancyAssociated with negative outcomesPretermHypothyroidismAutoimmunityThyroidTrial dataOutcomesDeliveryGestationComplicationsPhysician Use of Large Language Models: A Quantitative Study Based on Large-Scale Query-Level Data
Qiu L, Tang C, Bi X, Burtch G, Chen Y, Zhang H. Physician Use of Large Language Models: A Quantitative Study Based on Large-Scale Query-Level Data. Journal Of Medical Internet Research 2025, 27: e76941. PMID: 40854236, PMCID: PMC12377787, DOI: 10.2196/76941.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSensitive informationPresence of sensitive informationRisk of privacy breachesPhysician usePrivacy breach riskPhysician queriesPhysician demographicsPhysician interactionUsage patternsClinical questionsProportion of clinical questionsQuery levelGenerative artificial intelligencePrivacy breachesSensitive classifiersLanguage modelMobile devicesUse casesQueryResearch workflowArtificial intelligencePatient privacyBreach riskPhysician engagementMedical technology departmentsS‐GMAS: Genome‐Wide Mediation Analysis With Brain Subcortical Shape Mediators
Ding S, Liu R, Srivastava A, Nowakowski R, Shen L, Thompson P, Zhang H, Huang C. S‐GMAS: Genome‐Wide Mediation Analysis With Brain Subcortical Shape Mediators. Human Brain Mapping 2025, 46: e70297. PMID: 40741986, PMCID: PMC12311987, DOI: 10.1002/hbm.70297.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsSingle-nucleotide polymorphismsMediation analysisGenetic exposuresPotential genetic variantsMediation analysis frameworkBrain imaging phenotypesSignificant mediation effectGenetic variantsGenetic effectsSubcortical shapeAlzheimer's Disease Neuroimaging InitiativeMediation effectSquare-root velocity function representationBrainIndirect effectsNeurological pathwaysClinical outcomesPathwayImaging phenotypesHilbert spaceHilbert subspaceStatistical inferenceMediatorsA Unified Framework for Residual Diagnostics in Generalized Linear Models and Beyond
Liu D, Lin Z, Zhang H. A Unified Framework for Residual Diagnostics in Generalized Linear Models and Beyond. Journal Of The American Statistical Association 2025, ahead-of-print: 1-13. DOI: 10.1080/01621459.2025.2504037.Peer-Reviewed Original ResearchEfficacy of balloon stent or oral estrogen for adhesion prevention in septate uterus: A randomized clinical trial
Deng S, Zhao Z, Feng L, Huang X, Wang S, Xue X, Yan L, Ma B, Hao L, Li X, Yang L, Si M, Zhang H, Chen Z, Zhu L. Efficacy of balloon stent or oral estrogen for adhesion prevention in septate uterus: A randomized clinical trial. Chinese Medical Journal 2025, 138: 985-987. PMID: 40143426, PMCID: PMC12037080, DOI: 10.1097/cm9.0000000000003473.Peer-Reviewed Original ResearchEvaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene
Johnson J, Siblini H, Al‐Hendy A, Segars J, González F, Taylor H, Singh B, Carson S, Christman G, Huang H, Dangi B, Zhang H. Evaluating the Effect of Epigallocatechin Gallate (EGCG) in Reducing Folate Levels in Reproductive Aged Women by MTHFR and DHFR Genotype in Combination With Letrozole or Clomiphene. Clinical And Translational Science 2025, 18: e70189. PMID: 40077973, PMCID: PMC11903501, DOI: 10.1111/cts.70189.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsEpigallocatechin-3-gallateFolate levelsUterine fibroidsClinical trialsGreen tea extractAssociated with folate deficiencyPresence of MTHFRWomen of Childbearing AgeSerum folate levelsReduced folate levelsActive clinical trialsReproductive-age womenEffect of epigallocatechin gallateDHFR genotypeDHFR polymorphismTea extractDaily doseClomiphene citrateUnexplained infertilityFolate deficiencyChildbearing ageClinical studiesTreated womenFibroidsLetrozoleIdentifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation
Dai W, Zhang H. Identifying Genetic Variants for Brain Connectivity Using Ball Covariance Ranking and Aggregation. Journal Of The American Statistical Association 2025, ahead-of-print: 1-19. PMID: 40958822, PMCID: PMC12435467, DOI: 10.1080/01621459.2025.2450837.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsDetect single nucleotide polymorphismsGene-based analysisControlling false discovery rateControlling false discoveriesSNP setsFunctional connectivityFalse discovery rateGenetic architectureNovel genesGenetic basisNucleotide polymorphismsGenetic variantsUK Biobank dataPsychiatric disordersDiscovery rateBrain functionFalse discoveriesBiobank dataCorrelations of neural activityBrain regionsBiological etiologyBrain connectivityEQTLNeural activitySex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data
Hu Y, Che M, Zhang H. Sex‐Specific Association Between Polymorphisms in Estrogen Receptor Alpha Gene (ESR1) and Depression: A Genome‐Wide Association Study of All of Us and UK Biobank Data. Genetic Epidemiology 2025, 49: e70004. PMID: 40007508, PMCID: PMC11924109, DOI: 10.1002/gepi.70004.Peer-Reviewed Original ResearchMeSH Keywords and ConceptsConceptsGenome-wide association studiesSingle-nucleotide polymorphismsAssociation studiesAlpha geneEstrogen receptor alpha geneGenetic risk factorsRisk lociGenomic associationsMajor depressive disorderMDD phenotypesGenetic studiesGenetic associationRisk factors of MDDGenesESR1 geneUK BiobankESR1Participant genotypesPolymorphismSex-SpecificSex-specific associationsDepressive disorderRacial/ethnic disparitiesFindings lack consistencyLength of lifeEmpowering genome-wide association studies via a visualizable test based on the regional association score
Jiang Y, Zhang H. Empowering genome-wide association studies via a visualizable test based on the regional association score. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2419721122. PMID: 39999171, PMCID: PMC11892588, DOI: 10.1073/pnas.2419721122.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2024
A relook at the relevance of thyroid stimulating hormone and thyroid autoimmunity for pregnancy outcomes: Analyses of randomized control trials data from Pregnancy in Polycystic Ovary Syndrome and Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation
Kuokkanen S, Seungdamrong A, Santoro N, Lieman H, Sun F, Wild R, Zhang H, Pal L. A relook at the relevance of thyroid stimulating hormone and thyroid autoimmunity for pregnancy outcomes: Analyses of randomized control trials data from Pregnancy in Polycystic Ovary Syndrome and Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation. Fertility And Sterility 2024, 123: 873-882. PMID: 39672366, PMCID: PMC12045735, DOI: 10.1016/j.fertnstert.2024.12.005.Peer-Reviewed Original ResearchCitationsAltmetricConceptsThyroid-stimulating hormoneRandomized Controlled TrialsTPO-AbThyroid autoimmunityPregnancy outcomesAssessment of Multiple Intrauterine GestationsRetrospective cohort analysis of dataRisk of pregnancy lossEarly preterm birthMaternal TSH levelsThyroid peroxidase antibodyCohort analysis of dataRetrospective cohort analysisBody mass indexDuration of infertilityAnalysis of RCT dataPolycystic ovary syndromeIntrauterine gestationPreterm birthTSH levelsPeroxidase antibodiesOvarian stimulationLive birthsPPCOS IIStimulating hormone
Clinical Trials
Current Trials
FRIEND study- Fibroids and Unexplained Infertility Treatment with Epigallocatechin Gallate; A Natural CompounD in Green Tea
HIC ID2000032871RolePrincipal InvestigatorPrimary Completion Date05/31/2025Recruiting ParticipantsGenderFemaleAge18 years - 40 yearsPharmacokinetics and Hepatic Safety of EGCG
HIC ID2000029129RolePrincipal InvestigatorPrimary Completion Date09/30/2021Recruiting ParticipantsGenderFemaleAge18 years - 40 years
Academic Achievements & Community Involvement
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Activities
activity Connecticut Academy of Science and Engineering
07/01/2025 - PresentProfessional OrganizationsCouncil Memberactivity Live Birth After Fresh Embryo Transfer Vs Frozen-thawed Embryo Transfer in Women With Polycystic Ovary Syndrome (FreFro-PCOS)
01/01/2012 - 01/01/2014ResearchDetailsJinan, Shandong Sheng, ChinaAbstract/SynopsisFrom http://Clinicaltrials.gov: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of childbearing age. However, the optimal infertility treatment for PCOS patients is still a matter of controversy. Despite producing more follicles and more oocytes than other women undergoing controlled ovarian hyperstimulation during an IVF cycle, women with PCOS have comparable or lower pregnancy rates. Additionally women with PCOS patients undergoing IVF have a higher risk of developing ovarian hyperstimulation syndrome (OHSS), which may be aggravated by pregnancy after an embryo transfer in a fresh cycle. Further women with PCOS are thought to have higher rates of later pregnancy complications including spontaneous abortion, pre-eclampsia, and preterm labor that may be related to impaired implantation in the superovulated endometrium. We propose a randomized clinical trial of elective embryo cryopreservation followed by a programmed cycle of endometrial preparation and frozen embryo transfer (FET) compared to fresh embryo transfer in women with PCOS undergoing in vitro fertilization (IVF).
Honors
honor Highly Cited Researcher in Cross Field
11/15/2023International AwardWeb of Sciencehonor Distinguished Achievement Award
08/09/2023International AwardInternational Chinese Statistical Associationhonor Neyman Award and Lecture
06/29/2022International AwardInstitute of Mathematical StatisticsDetailsUnited Stateshonor Royan International Research Award
09/08/2011International AwardRoyan InstituteDetailsUnited Stateshonor Medallion Award and Lecturer
03/03/2011International AwardInstitute of Mathematical Statistics
News
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News
- July 23, 2025
Digging into data science at the 38th Annual New England Statistical Symposium
- September 30, 2024
Pepper Center Awards Drive Aging and Dementia Studies
- August 17, 2023
Biostatistics leaders honored by ICSA
- August 19, 2022
Yale Biostatistician Heping Zhang Delivers Prestigious Neyman Lecture
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New Haven, CT 06511