1. Tailored Technical Assistance
Implementation Science...
...Study Designs
...Frameworks
...Strategies
...Measures
...Outcomes
...Mentoring
...Partnership Formation & Sustainment
for designated EHE researchers and implementers.
R3EDI HIV Implementation Science Hub
Rigorous, Rapid and Relevant Evidence aDaptation and Implementation (R3EDI) for Ending the HIV Epidemic (EHE)
Renewing the R3EDI commitment at Yale in supporting community-engaged research through advanced implementation science methods.
2025-2030
The R3EDI Hub at Yale is supported by the National Institute of Allergy and Infectious Diseases (NIAID) under a renewed, five year grant to advance implementation science methods and strengthen community-engaged research across all 57 Ending the HIV Epidemic (EHE) jurisdictions.
The R3EDI Hub is part of a nationwide resource and consultation network, the Capacity-building Hubs to Enhance the Science of HIV Implementation REsearch (CHESHIRE) network, that operates in collaboration with a single U.S. coordination, consultation, and data management center, the HIV Implementation Science Coordination Initiative (ISCI) at Northwestern University. Each of the eight hubs delivers technical assistance, webinars, workshops, and mentoring to assigned project teams proposing and conducting EHE-relevant research, as well as additional HIV researchers and implementing partners in multiple EHE regions.
The focus of the R3EDI at Yale is on:
1) Advanced quantitative and qualitative Implementation Science methods
2) Community-engaged research (CEnR)
These two focus areas draw on expertise at the Yale School of Public Health’s Center for Methods in Implementation and Prevention Science (CMIPS) and Center for Interdisciplinary Research on AIDS (CIRA) to advance implementation science and community-engaged approaches in EHE regions.
Based on needs identified through prior EHE support, we have assembled an exceptional team to provide technical assistance and technical resources in the following areas, including:
- Community-Based Participatory Research (CBPR) Accelerator
- Implementing Partners Community of Practice (CoP)
- Social Determinants of Health database covering all 57 EHE jurisdictions
- Community-facing dissemination templates
- Multi-site research within the CHESHIRE Network
- HIV Visiting Scholars Program
What we aim to achieve
2. Technical Resources, Systemic Reviews, & Evaluations
Implementation Science...
...Webinars
...Workshops
...Reference Materials
...Systemic Reviews
...Social Determinants of Health Database
...Evaluations of Technical Resources3. CHESHIRE Network & ISCI
Implementation Science...
...Strategic & Technical Leadership Collaboration
2020-2025
R3EDI was established at the Yale School of Public Health and CIRA through an award from the National Institute of Mental Health (NIH) to Dr. Donna Spiegelman as one of five Implementation Science Technical Assistance hubs. Initially funded as one-year supplements, these hubs were designed to catalyze the Ending the HIV Epidemic: A Plan for America (EHE) by synthesizing knowledge across projects and strengthening implementation science research and collaborations. The EHE initiative sets a bold vision to end the HIV epidemic as a public health threat by ensuring that all Americans have access to innovative prevention and treatment tools, beginning in the 57 geographic areas where 80% of new HIV infections occur.
During this period, R3EDI supported 20 EHE projects across 11 states, including New York, New Jersey, Pennsylvania, Illinois, Florida, Georgia, Alabama, Mississippi, Texas, and California.
Developed to connect researchers and projects nationwide, offering expert support, shared tools, and streamlined data to drive impact.
Co-Principal Investigators
Associate Professor Adjunct of Epidemiology (Chronic Diseases); Affiliated Faculty, Yale Institute for Global Health
Since 1996 I have worked and partnered with public health systems and service organizations to strengthen service delivery. I have also taught, advised and conducted research at the Yale School of Public Health, working closely with hundreds of MPH students as they conducted applied public health practice projects in collaboration with public health systems and organizations. Many of my research projects have also been at the community level, where I provide expertise in engagement, relationship building and knowledge generation. I have broad expertise in community health systems and applied public health research and teaching, as well as skills in strategic thinking, mentoring and communication. Beginning in 2024 I co-lead the Rigorous, Rapid and Relevant Evidence aDaptation and Implementation (R3EDI) to Ending the HIV Epidemic (EHE) Implementation Science Technical Assistance Hub. We provide implementation science technical support and resources for researchers and practitioners working in the area of HIV implementation science in the United States. In addition to my implementation science work I also address interactions between nutrition and infectious disease. Over the last 18 years I have collaborated with Dr. Michael Cappello and the Noguchi Memorial Institute for Medical Research in Ghana on longitudinal studies characterizing parasite and host factors affecting response to deworming in Ghana.Associate Professor of Epidemiology (Microbial Diseases) and of Medicine (Pulmonary, Critical Care and Sleep Medicine); Affiliated Faculty, Yale Institute for Global Health; Affiliated Faculty, Yale Institute for Global Health; Director, Implementation Science Track
I am a pulmonary and critical care physician and clinical epidemiologist using implementation science to find, treat, and prevent tuberculosis (TB) and HIV, two of the leading cause of death due to infection worldwide. I teach and mentor students and direct a graduate program on implementation science at the Yale School of Public Health. I am also involved in several international research training programs focused on implementation science. I am also a Yale Medicine physician, and attend in the Medical Intensive Care Unit and the Winchester TB Clinic at Yale-New Haven Hospital, caring for patients and their families and teaching medical students, residents, and fellows.
Core Team
Research Scientist in Biostatistics (CMIPS); Director, Dissemination and Implementation Science Methods (DISM) Core, Center for Interdisciplinary Research on AIDS; Affiliated Faculty, Yale Institute for Global Health
Raul U. Hernandez-Ramirez is a Research Scientist in Biostatistics at the Center for Methods in Implementation and Prevention Science (CMIPS) and Director of the Dissemination and Implementation Science Methods (DISM) Core at the Center for Interdisciplinary Research on AIDS (CIRA). His research mainly focuses on HIV/AIDS, cancer, and implementation science (IS). He also conducts research to develop and apply causal inference methods for the evaluation of HIV prevention interventions and methods to account for exposure uncertainty in environmental health studies. He collaborates on research projects and grants in New Haven and other settings in the US, as well as in low- and middle-income countries, including Mexico and others. He is interested in adapting/developing and applying interventions to increase the uptake of evidence-based interventions and practices for prevention and care of HIV and of cancer (e.g., follow up care for abnormal cervical cancer screens) and strategies to enable their implementation. He is a member of the Yale Cancer Center (YCC) and the Yale Institute for Global Health (YIGH). He provides expertise, consultations, and technical assistance and seminars and trainings on IS and research methods, design, and analysis to CIRA affiliates through CIRA’s DISM core and and projects in Ending the HIV Epidemic (EHE) priority areas through the CIRA affiliated IS hub R3EDI (Rigorous, Rapid, & Relevant Evidence aDaptation & Implementation to EHE). He completed a PhD in Public Health (Chronic Disease Epidemiology) at Yale and conducted part of his doctoral dissertation research as a predoctoral visiting fellow at the National Cancer Institute (NCI). He subsequently completed the Training Institute for Dissemination and Implementation Research in Cancer (TIDIRC) and the Multilevel Intervention Training Institute (MLTI) from NCI, as well as the training in optimization of multicomponent interventions using the Multiphase Optimization Strategy (MOST) by Dr. Linda Collins. Before coming to Yale, he gained substantial research experience in nutrition, environment health, and cancer at the National Institute of Public Health of Mexico. He spent several years in Mexico working as a researcher and instructor and was the project coordinator, data manager, and main statistician for a multistate study. He previously obtained a MSc in Epidemiology and a BSc in Nutrition.Associate Research Scientist in Biostatistics
Dr. Nikita Rao is a health outcomes researcher whose work spans health disparities, place-based social determinants of health, and applied health economics. At the Yale School of Public Health, she leads analyses for pilot randomized controlled trials, conducts psychometric evaluations of mental health and behavioral measures, and supports systematic reviews and data dashboard development to advance Ending the HIV Epidemic (EHE) research. Her doctoral training at Georgia State University included a multi-method dissertation integrating multilevel modeling, structural equation modeling, and meta-analysis to understand how social determinants shape health equity, alongside a postdoctoral fellowship focused on mapping care pathways for unhoused individuals in Atlanta. Prior to her PhD, Dr. Rao worked as a clinical outcomes researcher at the University of Washington and Children’s Healthcare of Atlanta, contributing to multicenter clinical trials, regulatory processes, and the development and validation of patient-reported outcome measures.Associate Research Scientist
Dr. Simon is an Associate Research Scientist in Public Health () and the Center for Methods in Implementation and Prevention Science (CMIPS) at the Yale School of Public Health. She is a social epidemiologist whose research focuses on social and behavioral determinants of health, parenting, and community engagement. She applies both qualitative and quantitative methods to strengthen our understanding of the social and behavioral pathways that influence health and wellbeing of high-risk and vulnerable populations such as people impacted by HIV and justice-impacted populations. Dr. Simon has co-authored peer-reviewed articles and a book chapter addressing Black Mental Health. She has presented her research domestically and internationally, including at the Danish and European Parliaments.
Co-Investigators
Professor of Medicine (General Medicine); Associate Professor on Term, Social and Behavioral Sciences
- Appt
- Clinic Fax
Associate Professor of Public Health (Social and Behavioral Sciences); Affiliated Faculty, Yale Institute for Global Health
Associate Professor of Biostatistics and Associate Professor of Medicine (Cardiovascular Medicine)
Independence Foundation Professor of Nursing; Associate Professor , Social & Behavioral Health
Susan Dwight Bliss Professor of Biostatistics; Director, Center for Methods in Implementation and Prevention Science (CMIPS); Professor of Statistics and Data Science; Professor of Medicine (Cardiovascular Medicine); Assistant Director, Global Oncology, Yale Cancer Center
Program Administrator
Consultants
Trainees
MPH Students
| Christopher Alvarez | Joy Peters | Lingling Zheng |
- (MPH) Implementation Science TrackThis MPH degree track prepares students to acquire key competencies in four methodological areas building on MPH core courses in biostatistics, epidemiology, ethics, health equity, and health policy and complements each department’s course requirements.
- Center for Interdisciplinary Research on AIDS (CIRA)CIRA provides HIV-related resources, skills, services, training, and professional networking opportunities to HIV researchers and practitioners who can contribute to advances in HIV prevention and treatment.