Salome Charalambous
Associate Professor AdjunctCards
About
Research
Publications
2025
N-acetylcysteine modulates markers of oxidation, inflammation and infection in tuberculosis
Mapamba D, Sabi I, Lalashowi J, Sauli E, Buza J, Olomi W, Mtafya B, Kibona M, Bakhuli A, Rachow A, Velen K, Hoelscher M, Ntinginya N, Charalambous S, Churchyard G, Wallis R, consortium T. N-acetylcysteine modulates markers of oxidation, inflammation and infection in tuberculosis. Journal Of Infection 2025, 106379. PMID: 39756697, DOI: 10.1016/j.jinf.2024.106379.Peer-Reviewed Original Research
2024
Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia
Goscé L, Tadesse A, Foster N, van Kalmthout K, van Rest J, van der Wal J, Harker M, Madden N, Abdurhman T, Gadissa D, Bedru A, Dube T, Alacapa J, Mganga A, Deyanova N, Charalambous S, Letta T, Jerene D, White R, Fielding K, Houben R, McQuaid C. Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia. BMJ Global Health 2024, 9: e016997. PMID: 39653521, PMCID: PMC11628985, DOI: 10.1136/bmjgh-2024-016997.Peer-Reviewed Original ResearchConceptsDigital adherence technologiesHealthcare providersTB deathsPatient cost savingsStandard of careAdherence technologiesLabelling interventionsEpidemiological impactASCENT trialDifferentiated careMedication labelsIncident TBImprove tuberculosisProvider costsTB incidenceCareTB episodeProvidersCompartmental transmission modelPotential long-termCost of treatmentInterventionTreatment completionHealthcareEpidemiological benefitsBurden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis
Holtgrewe L, Johnson A, Nyhan K, Boffa J, Shenoi S, Karat A, Davis J, Charalambous S. Burden of tuberculosis in underserved populations in South Africa: A systematic review and meta-analysis. PLOS Global Public Health 2024, 4: e0003753. PMID: 39361564, PMCID: PMC11449336, DOI: 10.1371/journal.pgph.0003753.Peer-Reviewed Original ResearchLatent TB infection prevalenceLatent TB infectionUnderserved populationsTB prevalenceMeta-analysisSystematic reviewNational averagePrevalence of TB diseaseCalculate prevalence ratiosTB diseaseCase-finding strategiesPopulation of personsAssessed study qualityHigh TB prevalenceHigh-burden countriesBurden of tuberculosisTB interventionsPrevalence ratiosStudy qualityReduce tuberculosisHIV statusActive TB diseaseGeneral populationModerate heterogeneityTB incidenceAdjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis.
Wallis R, Sabi I, Lalashowi J, Bakuli A, Mapamba D, Olomi W, Siyame E, Ngaraguza B, Chimbe O, Charalambous S, Rachow A, Ivanova O, Zurba L, Myombe B, Kunambi R, Hoelscher M, Ntinginya N, Churchyard G. Adjunctive N-Acetylcysteine and Lung Function in Pulmonary Tuberculosis. NEJM Evidence 2024, 3: evidoa2300332. PMID: 39189858, DOI: 10.1056/evidoa2300332.Peer-Reviewed Original ResearchConceptsWhole blood glutathione levelsLung functionN-acetylcysteinePulmonary tuberculosisCulture conversionSecondary outcomesGlutathione levelsEffect of N-acetylcysteineTuberculosis treatment outcomesOutcome of lung functionOral N-acetylcysteineRecovery of lung functionAdjunctive N-acetylcysteineAssociated with improved recoveryN-acetylcysteine treatmentPermanent lung injuryFar-advanced tuberculosisSputum cultureStandard therapyNAC administrationAdverse eventsLung injuryGlobal health concernCohort studyClinical evaluationUsing mHealth Technologies for Case Finding in Tuberculosis and Other Infectious Diseases in Africa: Systematic Review
Mudzengi D, Chomutare H, Nagudi J, Ntshiqa T, Davis J, Charalambous S, Velen K. Using mHealth Technologies for Case Finding in Tuberculosis and Other Infectious Diseases in Africa: Systematic Review. JMIR MHealth And UHealth 2024, 12: e53211. PMID: 39186366, PMCID: PMC11384173, DOI: 10.2196/53211.Peer-Reviewed Original ResearchHealth-seeking behaviour and patient-related factors associated with the time to TB treatment initiation in four African countries: a cross-sectional survey
Sathar F, Charalambous S, Velen K, Fielding K, Rachow A, Ivanova O, Rassool M, Lalashowi J, Owolabi O, Nhassengo P, Chihota V, Evans D. Health-seeking behaviour and patient-related factors associated with the time to TB treatment initiation in four African countries: a cross-sectional survey. BMJ Public Health 2024, 2: e001002. DOI: 10.1136/bmjph-2024-001002.Peer-Reviewed Original ResearchTB treatment initiationCross-sectional surveyTB symptomsPrimary care facilitiesTreatment initiationMedian total delayHealth-seeking behaviorNational TB Control ProgrammeTB treatmentCohort of adultsTB control programmesActive case findingPatient-related factorsHealth facilitiesTB servicesHIV prevalenceCare facilitiesDrug-susceptible pulmonary TBTotal delaySecond-leading causeTime to treatment initiationCase findingCox regression modelsStructured questionnaireInitiation of treatmentReaching for 90:90:90 in Correctional Facilities in South Africa and Zambia: Virtual Cross-Section of Coverage of HIV Testing and Antiretroviral Therapy During Universal Test and Treat Implementation
Hoffmann C, Herce M, Chimoyi L, Smith H, Tlali M, Olivier C, Topp S, Muyoyeta M, Reid S, Hausler H, Charalambous S, Fielding K. Reaching for 90:90:90 in Correctional Facilities in South Africa and Zambia: Virtual Cross-Section of Coverage of HIV Testing and Antiretroviral Therapy During Universal Test and Treat Implementation. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 96: 465-471. PMID: 38985444, DOI: 10.1097/qai.0000000000003456.Peer-Reviewed Original ResearchHIV testingCross-sectional analysisAntiretroviral therapyCoverage of HIV testingHIV statusHIV testing coverageUniversal testingHIV epidemic controlTreatment dataCohort-based studyAntiretroviral therapy initiationRoutine dataUTT implementationBackground PeopleCorrectional facilitiesCensus listsZambian sitesHIVSouth AfricaSouth African sitesEpidemic controlUTTCorrectional settingsTherapyFacilitiesTreatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial
Charalambous S, Maraba N, Jennings L, Rabothata I, Cogill D, Mukora R, Hippner P, Naidoo P, Xaba N, Mchunu L, Velen K, Orrell C, Fielding K. Treatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial. EClinicalMedicine 2024, 75: 102745. PMID: 39170937, PMCID: PMC11338121, DOI: 10.1016/j.eclinm.2024.102745.Peer-Reviewed Original ResearchEvidence of improved adherenceTreatment adherencePrimary health clinicsCluster randomised trialCluster randomized trialStandard of careDifferentiated care approachesPoor treatment adherenceMedical monitoringCare approachHealth clinicsAdherence reportsLower treatment completionCluster designDrug-susceptible tuberculosisPrimary outcomeRandomised trialsDrug-sensitive tuberculosisAdherenceTreatment completionCareParticipantsSouth AfricaRandomized trialsFollow-upLung outcomes and related risk factors in patients after SARS-CoV-2 infection: a hospitalised single-centre cohort from Johannesburg, South Africa
Glover N, Ivanova O, Sathar F, Riess F, Shambhu R, Mekota A, Zurba L, Menezes C, van Blydenstein S, Kalla I, Hoelscher M, Saathoff E, Charalambous S, Rachow A. Lung outcomes and related risk factors in patients after SARS-CoV-2 infection: a hospitalised single-centre cohort from Johannesburg, South Africa. EClinicalMedicine 2024, 71: 102588. PMID: 38623400, PMCID: PMC11016864, DOI: 10.1016/j.eclinm.2024.102588.Peer-Reviewed Original ResearchSt George's Respiratory QuestionnaireBody mass indexWorld Health OrganizationRisk factorsChest CTAssessed body mass indexSARS-CoV-2 infectionCOVID-19 severityTB diseaseGeorge's Respiratory QuestionnaireMedian 6MWT distanceChris Hani Baragwanath Academic HospitalSt George's Respiratory Questionnaire total scoreQuality of lifeGt;35 kg/m<sup>2</sup>High-resolution chest CTObservational cohort studySingle-centre cohortPost-SARS-CoV-2 infectionRespiratory QuestionnairePost-COVID-19 sequelaePost-dischargeSARS-CoV-2Significant risk factorsHospitalised adultsA pilot cross-sectional study of non-communicable diseases in TB household contacts
Hamada Y, Lugendo A, Ntshiqa T, Kubeka G, Lalashowi J, Mwastaula S, Ntshamane K, Sabi I, Wilson S, Copas A, Velen K, Ntinginya N, Minja L, Abubakar I, Charalambous S, Rangaka M. A pilot cross-sectional study of non-communicable diseases in TB household contacts. IJTLD OPEN 2024, 1: 154-159. PMID: 38988408, PMCID: PMC11231826, DOI: 10.5588/ijtldopen.23.0579.Peer-Reviewed Original ResearchNon-communicable diseasesTB household contactsNon-communicable disease screeningStudy of non-communicable diseasePrevalence of non-communicable diseasesPilot cross-sectional studyContact investigationCross-sectional studyIntegrated screeningHousehold contactsHemoglobin A1cNeighborhood householdsPrevalenceBlood pressureBlood glucoseSouth AfricaAdult contactsScreeningCareNeighborhoodIndividualsA1cDiabetesDiseasePilot