2024
Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US
Lin Z, Ye J, Allore H, Gill T, Chen X. Early-Life Circumstances and Racial Disparities in Cognition Among Older Adults in the US. JAMA Internal Medicine 2024, 184: 904-914. PMID: 38805197, PMCID: PMC11134283, DOI: 10.1001/jamainternmed.2024.1132.Peer-Reviewed Original ResearchEarly-life circumstancesLate-life cognitionRacial disparitiesCross-sectional studyBlack participantsWhite participantsCognitive scoresCognitive impairmentRacial differencesTelephone Interview for Cognitive StatusHealth and Retirement StudyAssociated with racial disparitiesPromote health equityPrevalence of cognitive impairmentIntervention of cognitive impairmentNon-Hispanic blacksSurvey of US adultsNon-Hispanic whitesReduce racial disparitiesPrimary explanatory variableSubstantial racial differencesHealth equityRetirement StudyOlder AdultsUS adultsPlace of Birth and Cognitive Function Among Older Americans: Findings From the Harmonized Cognitive Assessment Protocol
Lin Z, Chen X. Place of Birth and Cognitive Function Among Older Americans: Findings From the Harmonized Cognitive Assessment Protocol. The Journals Of Gerontology Series B 2024, 79: gbae126. PMID: 39037282, PMCID: PMC11322604, DOI: 10.1093/geronb/gbae126.Peer-Reviewed Original ResearchHealth and Retirement StudyLife courseGeographic disparitiesHarmonized Cognitive Assessment ProtocolCognitive functionPlace-based policiesPromote health equityLater-life cognitive functionForeign-born individualsLater-life outcomesUS southern statesState of birthCognitive Assessment ProtocolNationally representative sampleLater-life cognitionHealth equityShapley decompositionOlder AmericansRetirement StudyGeneral cognitive functionHealth factorsAssessed cognitive domainsBirth dataRepresentative sampleSouthern statesAssociation of Family Support With Lower Modifiable Risk Factors for Dementia Among Cognitively Impaired Older Adults
Lin Z, Yin X, Levy B, Yuan Y, Chen X. Association of Family Support With Lower Modifiable Risk Factors for Dementia Among Cognitively Impaired Older Adults. American Journal Of Geriatric Psychiatry 2024, 32: 1187-1199. PMID: 38839462, PMCID: PMC11366488, DOI: 10.1016/j.jagp.2024.05.005.Peer-Reviewed Original ResearchModifiable risk factorsCognitively impaired older adultsOlder adultsFamily supportResidential proximitySpousal presenceRisk factorsDepressive symptomsCognitive impairmentModifiable dementia risk factorsHealth and Retirement StudyProportion of older adultsDementia risk factorsSocial isolationDegree of family supportPercentage of smokingMixed-effects logistic regressionRobust to various sensitivity analysesCo-resident childrenRetirement StudySocial supportNo spouseLogistic regressionSpousesProtective factorsAssociation between experiencing low healthcare quality and developing dementia
Aravena J, Chen X, Levy B. Association between experiencing low healthcare quality and developing dementia. Journal Of The American Geriatrics Society 2024, 72: 2126-2132. PMID: 38415796, PMCID: PMC11226361, DOI: 10.1111/jgs.18842.Peer-Reviewed Original ResearchAssociated with increased dementia riskHealthcare qualityDementia riskHealthcare discriminationAssociated with greater dementia riskHazard ratioHealth and Retirement StudyDeterminants of dementiaCases of dementiaDementia prevalenceReducing dementiaPhysician diagnosisRetirement StudyHealthcare servicesOlder personsOlder adultsSocioeconomic factorsDementiaHealthcareImplement structural changesCognitive scoresCox regressionParticipantsHealthIndividual-level behaviorApplying Machine Learning Approach to Explore Childhood Circumstances and Self-Rated Health in Old Age — China and the US, 2020–2021
Huo S, Feng D, Gill T, Chen X. Applying Machine Learning Approach to Explore Childhood Circumstances and Self-Rated Health in Old Age — China and the US, 2020–2021. China CDC Weekly 2024, 6: 213-218. PMID: 38532746, PMCID: PMC10961215, DOI: 10.46234/ccdcw2024.043.Peer-Reviewed Original ResearchSelf-rated healthSenior healthChildhood circumstancesPromote health equityEarly-life interventionsHealth equityChina HealthChildhood healthRetirement StudyHealthSelf-ratingsAging populationFinancial statusChinese participantsAge ChinaConditional inference treesChildhoodOut-of-sample mean squared errorsInterventionParticipantsRegional differencesUSStatusInference treesRetirement
2019
Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study
Liu Z, Chen X, Gill TM, Ma C, Crimmins EM, Levine ME. Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study. PLOS Medicine 2019, 16: e1002827. PMID: 31211779, PMCID: PMC6581243, DOI: 10.1371/journal.pmed.1002827.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseArtery diseasePhenotypic agingUS older adultsSelf-reported circumstancesRetirement StudyLife course circumstancesAssociation of geneticMorbidity riskMultivariable associationsPotential policy targetsRetrospective natureAdulthood circumstancesPhenotypic AgeAdulthood adversityGenetic predispositionHealth behaviorsSocioenvironmental circumstancesUS populationOlder adultsPotential interventionsDisadvantaged subpopulationsGenetic riskGenetic scoreUS Health