Investigating gene functions and single-cell expression profiles of de novo variants in orofacial clefts
Itai T, Yan F, Liu A, Dai Y, Iwaya C, Curtis S, Leslie E, Simon L, Jia P, Chen X, Iwata J, Zhao Z. Investigating gene functions and single-cell expression profiles of de novo variants in orofacial clefts. Human Genetics And Genomics Advances 2024, 5: 100313. PMID: 38807368, PMCID: PMC11318074, DOI: 10.1016/j.xhgg.2024.100313.Peer-Reviewed Original ResearchDe novo variantsCPO geneOMIM genesGene functionScRNA-seq data analysisOrofacial cleftsMan (OMIMScRNA-seq analysisOnline Mendelian InheritanceSingle-cell RNA sequencingSingle-cell expression profilesInvestigate gene functionCleft palateScRNA-seqGene setsCellular expression profilesMendelian inheritanceGenetic variantsRNA sequencingOrofacial clefting genesContextual geneGenesExpression patternsCongenital birth defectsExpression profilesUnveiling Gene Interactions in Alzheimer’s Disease by Integrating Genetic and Epigenetic Data with a Network-Based Approach
Sanders K, Manuel A, Liu A, Leng B, Chen X, Zhao Z. Unveiling Gene Interactions in Alzheimer’s Disease by Integrating Genetic and Epigenetic Data with a Network-Based Approach. Epigenomes 2024, 8: 14. PMID: 38651367, PMCID: PMC11036294, DOI: 10.3390/epigenomes8020014.Peer-Reviewed Original ResearchEnrichment analysisGenome-wide association studiesAlzheimer's diseaseDense module searchDNA methylation dataGene network modulesFunctional enrichment analysisGWAS signalsGWAS datasetsTarget enrichmentAssociation studiesGenetic dataEpigenetic signalsNetwork-based toolCause of dementiaGene interactionsAD pathogenesisMethylation dataDNA methylationBIN1 geneAD pathologyComplex diseasesGenesSignificant cell typeDrug repurposing efforts