Are Survey-Based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study
Cohen T, Colijn C, Finklea B, Wright A, Zignol M, Pym A, Murray M. Are Survey-Based Estimates of the Burden of Drug Resistant TB Too Low? Insight from a Simulation Study. PLOS ONE 2008, 3: e2363. PMID: 18523659, PMCID: PMC2408555, DOI: 10.1371/journal.pone.0002363.Peer-Reviewed Original ResearchConceptsResistant tuberculosisIncident casesTotal burdenDrug-resistant TBDrug-resistant tuberculosisSecond-line antibioticsDrug treatment regimensDrug sensitivity testingDrug-resistant strainsBurden of resistanceEmergence of tuberculosisResistant TBTreatment regimensPrevalent casesWorldwide burdenIntroduction of interventionsRoutine surveillanceSurveillance strategiesDrug resistanceTuberculosisLaboratory capacityMycobacterium tuberculosisSensitivity testingTuberculosis modelBurdenChallenges in Estimating the Total Burden of Drug-resistant Tuberculosis
Cohen T, Colijn C, Wright A, Zignol M, Pym A, Murray M. Challenges in Estimating the Total Burden of Drug-resistant Tuberculosis. American Journal Of Respiratory And Critical Care Medicine 2008, 177: 1302-1306. PMID: 18369201, PMCID: PMC2720088, DOI: 10.1164/rccm.200801-175pp.Peer-Reviewed Original ResearchConceptsDrug-resistant tuberculosisDrug resistance surveillanceHIV/TB coinfectionAnti-Tuberculosis Drug Resistance SurveillanceResistance surveillanceSentinel site surveillanceBurden of tuberculosisMultidrug-resistant diseaseMultidrug-resistant tuberculosisTB control programsTB coinfectionTB casesHigh burdenMethodologic obstaclesSurveillance studyNew casesTotal burdenTuberculosisLaboratory capacityBurdenSurveillanceControl programsDiagnostic technologiesRecent recognitionTrue extent