PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring
Wang J, Aksoy S. PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse’s offspring. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 10552-10557. PMID: 22689989, PMCID: PMC3387098, DOI: 10.1073/pnas.1116431109.Peer-Reviewed Original ResearchConceptsMother's milkImmune deficiency (IMD) pathwayPGRP-LBHost immune systemImmune system developmentIntrauterine environmentNutritional supplementationDietary supplementationHyperimmune responseImmune systemImpact immunityNewborn progenyParasite infectionAdultsParasitized adultsPeptidoglycan recognition proteinsSuch adultsImmunitySupplementationAntitrypanosomal activityPivotal roleMilkInductionHost fecundityMilk proteinsObligate Symbionts Activate Immune System Development in the Tsetse Fly
Weiss BL, Maltz M, Aksoy S. Obligate Symbionts Activate Immune System Development in the Tsetse Fly. The Journal Of Immunology 2012, 188: 3395-3403. PMID: 22368278, PMCID: PMC3311772, DOI: 10.4049/jimmunol.1103691.Peer-Reviewed Original ResearchConceptsSymbiotic bacteriaImmune system developmentNovel evolutionary adaptationImmunity-related genesObligate symbiontsSymbiotic microbesObligate mutualistsViviparous modeProper immune system functionEvolutionary adaptationPhagocytic hemocytesMolecular mechanismsCell extractsMolecular componentsSusceptible phenotypeNonpathogenic Escherichia coliEscherichia coliTsetse fliesImmune systemFliesAtypical expressionHemocytesImmune system functionPhenotypeTsetse