2011
Biomarkers of Hemolysis and Inflammation in Sickle Cell Disease Children: Association with Nasopharynx and Oropharynx Bacteria colonization
Rocha L, Seixas M, Cerqueira B, Lopes V, Reis M, Goncalves M. Biomarkers of Hemolysis and Inflammation in Sickle Cell Disease Children: Association with Nasopharynx and Oropharynx Bacteria colonization. Blood 2011, 118: 2140. DOI: 10.1182/blood.v118.21.2140.2140.Peer-Reviewed Original ResearchHigh ferritin serum levelsFerritin serum levelsSCD patientsSerum levelsS. pneumoniaeNasopharyngeal colonizationNasopharynx colonizationHbSS genotypeSickle cell disease childrenS. aureusBacteria colonizationBiomarkers of hemolysisHigher leukocyte numbersPneumococcal penicillin resistanceHigher neutrophil countS. pneumoniae colonizationCause of infectionCross-sectional studyOccurrence of infectionMultivariate analysis modelNeutrophil countSCD childrenHigh ferritinPneumonia occurrencePneumoniae colonization
2010
Iinsulin Levels and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) May Explain a Possible Important Role of the Pancreas In Sickle Cell Disease Patients Outcome
Seixas M, Lopes V, Cezar R, Carvalho G, Rocha L, Lyra I, Reis M, Goncalves M. Iinsulin Levels and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) May Explain a Possible Important Role of the Pancreas In Sickle Cell Disease Patients Outcome. Blood 2010, 116: 4811. DOI: 10.1182/blood.v116.21.4811.4811.Peer-Reviewed Original ResearchSickle cell diseaseC-reactive proteinInsulin levelsBlood cell countSCD patientsAspartate aminotransferaseHOMA-IRWBC countLactate dehydrogenaseHemoglobin concentrationCell countSeverity of SCDChronic sub-clinical inflammationWhite blood cell countSub-clinical inflammationHigher insulin levelsRed blood cell countCross-sectional studyLower insulin levelsHigher ferritin concentrationsHigher haptoglobin concentrationsImportant biomarkerInflammatory markersPain episodesChronic inflammation