2024
Detection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis?
Jacob-Nascimento L, Portilho M, Anjos R, Moreira P, Stauber C, Weaver S, Kitron U, Reis M, Ribeiro G. Detection of Chikungunya Virus RNA in Oral Fluid and Urine: An Alternative Approach to Diagnosis? Viruses 2024, 16: 235. PMID: 38400011, PMCID: PMC10891727, DOI: 10.3390/v16020235.Peer-Reviewed Original ResearchConceptsChikungunya virus infectionAcute-phase seraOral fluidChikungunya virusIgM seroconversionChikungunya virus diagnosisUrine samplesAcute febrile illnessConvalescent-phase seraAcute chikungunyaChikungunya patientsChikungunya virus RNADisease courseFebrile illnessPaired seraRT-qPCRAcute phaseIgM detectionConvalescent-phasePatientsControl group samplesSerumUrineCHIKV transmissionIgM
2023
Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study
Barbosa L, Santiago M, Moretto V, Athanazio D, Takahashi D, Reis E, Lopes M, Lemaire D, Reis M. Toll-like receptor 9 polymorphisms in brazilian patients with systemic lupus erythematosus: a pilot study. Brazilian Journal Of Biology 2023, 83: e244123. PMID: 34161457, DOI: 10.1590/1519-6984.244123.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusToll-like receptor 9TLR9 polymorphismsSLE patientsLupus erythematosusSingle nucleotide polymorphismsToll-like receptor 9 polymorphismsControl groupTLR9 single nucleotide polymorphismsSLE patient groupInnate immune systemDiscoid rashSLE populationClinical manifestationsPatient groupAutoimmune diseasesReceptor 9Brazilian patientsTLR9 geneImmune systemPatientsPilot studyAllele GAllele CGenotype frequenciesPrevalence of Genotypic Resistance Mutations in Patients with Chronic Hepatitis B (HBV) Treated with Entecavir and Tenofovir in Two Reference Centers in the North and Northeast of Brazil
Pacheco S, Schinoni M, Stocker A, Paraná R, Reis M, Silva L. Prevalence of Genotypic Resistance Mutations in Patients with Chronic Hepatitis B (HBV) Treated with Entecavir and Tenofovir in Two Reference Centers in the North and Northeast of Brazil. Medical Research Archives 2023, 11 DOI: 10.18103/mra.v11i3.3473.Peer-Reviewed Original ResearchGenotypic resistance mutationsResistance mutationsHepatitis BChronic hepatitis BFirst-line treatmentVaccine escape mutationsHepatitis B virusChronic HBVAntiviral treatmentLine treatmentLiver diseaseTherapeutic managementB virusEscape mutationsGenotypic resistanceReference centerPatientsGenetic mutationsEntecavirHBVTenofovirTreatmentNortheast of BrazilPresent studyNucleotide analogues
2022
The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series
Dias T, Tauro L, Macêdo L, Brito L, Ribeiro V, Santos C, Jacob-Nascimento L, Vilas-Boas L, Amado C, Barbosa P, Reis J, Campos G, Ribeiro G, Siqueira I, Silva L, Reis M. The emergence of arboviruses changes the profile of viral meningitis in Salvador, Bahia: A case series. Frontiers In Tropical Diseases 2022, 3: 1023588. DOI: 10.3389/fitd.2022.1023588.Peer-Reviewed Original ResearchVaricella-zoster virusViral meningitisReverse transcription-PCRDifferent arbovirusesAcute febrile illnessPossible viral etiologyCHIKV IgMDENV IgMFebrile illnessNeurological manifestationsCase seriesCommon etiologyViral etiologyZoster virusDENV serotypesNS1 antigenDifferential diagnosisCSF samplesMeningitisZIKVCHIKVPatientsViral surveillanceEtiologyEmergence of arbovirusesProlonged Outbreak of Carbapenem and Colistin-Resistant Klebsiella pneumoniae at a Large Tertiary Hospital in Brazil
Rocha V, Barbosa M, Leal H, Silva G, Sales N, de Souza Santos Monteiro A, Azevedo J, Malheiros A, Ataide L, Moreira B, Reis M, Bahia F, Reis J. Prolonged Outbreak of Carbapenem and Colistin-Resistant Klebsiella pneumoniae at a Large Tertiary Hospital in Brazil. Frontiers In Microbiology 2022, 13: 831770. PMID: 35356529, PMCID: PMC8959819, DOI: 10.3389/fmicb.2022.831770.Peer-Reviewed Original ResearchMinimum inhibitory concentrationTertiary hospitalColistin-resistant Klebsiella pneumoniaeAverage hospitalization stayMedian Charlson scoreSystemic arterial hypertensionCentral venous cathetersLarge tertiary hospitalAntimicrobial susceptibility profilesFrequent sequence typesCharlson scoreMonoclonal profilesHospitalization stayMain comorbiditiesArterial hypertensionVenous cathetersMechanical ventilationCerebrovascular diseasePatientsDemographic dataProlonged outbreakHealth systemSusceptibility profilesHigh lethalityPrevious use
2021
Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil
Silva M, Kikuti M, Anjos R, Portilho M, Santos V, Gonçalves T, Tauro L, Moreira P, Jacob-Nascimento L, Santana P, Campos G, Siqueira A, Kitron U, Reis M, Ribeiro G. Risk of chronic arthralgia and impact of pain on daily activities in a cohort of patients with chikungunya virus infection from Brazil. International Journal Of Infectious Diseases 2021, 105: 608-616. PMID: 33684559, DOI: 10.1016/j.ijid.2021.03.003.Peer-Reviewed Original ResearchConceptsChronic arthralgiaChikungunya virus infectionRisk factorsVirus infectionDaily activitiesAcute febrile illnessIndependent risk factorPersistence of painCohort of patientsImpact of painProgression of diseaseTranscriptase-polymerase chain reactionPersistent arthralgiaFebrile illnessSubstantial disabilityViral loadFemale sexPolymerase chain reactionIgM enzymeArthralgiaSurveillance studyChikungunya virusDengue virusPatientsImmunosorbent assay
2020
Early Release - Anicteric Leptospirosis-Associated Meningitis in a Tropical Urban Environment, Brazil - Volume 26, Number 9—September 2020 - Emerging Infectious Diseases journal - CDC
Nabity SA, Araújo GC, Hagan JE, Damião AO, Reis MG, Ko AI, Ribeiro GS. Early Release - Anicteric Leptospirosis-Associated Meningitis in a Tropical Urban Environment, Brazil - Volume 26, Number 9—September 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 2190-2192. PMID: 32818405, PMCID: PMC7454101, DOI: 10.3201/eid2609.191001.Peer-Reviewed Original ResearchInfluence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC
Hacker KP, Sacramento GA, Cruz JS, de Oliveira D, Nery N, Lindow JC, Carvalho M, Hagan J, Diggle PJ, Begon M, Reis MG, Wunder EA, Ko AI, Costa F. Influence of Rainfall on Leptospira Infection and Disease in a Tropical Urban Setting, Brazil - Volume 26, Number 2—February 2020 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2020, 26: 311-314. PMID: 31961288, PMCID: PMC6986844, DOI: 10.3201/eid2602.190102.Peer-Reviewed Original Research
2019
Evaluation of two commercially available chikungunya virus IgM enzyme-linked immunoassays (ELISA) in a setting of concomitant transmission of chikungunya, dengue and Zika viruses
Kikuti M, Tauro L, Moreira P, Nascimento L, Portilho M, Soares G, Weaver S, Reis M, Kitron U, Ribeiro G. Evaluation of two commercially available chikungunya virus IgM enzyme-linked immunoassays (ELISA) in a setting of concomitant transmission of chikungunya, dengue and Zika viruses. International Journal Of Infectious Diseases 2019, 91: 38-43. PMID: 31704226, DOI: 10.1016/j.ijid.2019.11.001.Peer-Reviewed Original ResearchConceptsConvalescent samplesIgM enzymeRT-PCRZika virus transmissionNegative patientsCHIKV infectionAcute samplesZIKV casesConvalescent seraSurveillance studyCHIKV transmissionZika virusCHIKV casesDiagnostic performanceLow specificityVirus transmissionEquivocal resultsTest sensitivitySerumELISA specificityPatientsHigh rateDengueConcomitant transmissionMore equivocal results
2014
HBV/HDV co‐infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers
Kay A, da Silva E, Pedreira H, Negreiros S, Lobato C, Braga W, Muwonge R, Dény P, Reis M, Zoulim F, Trepo C, D'Oliveira A, Salcedo J, Schinoni M, Parana R. HBV/HDV co‐infection in the Western Brazilian Amazonia: an intriguing mutation among HDV genotype 3 carriers. Journal Of Viral Hepatitis 2014, 21: 921-924. PMID: 25040045, DOI: 10.1111/jvh.12267.Peer-Reviewed Original ResearchAnti-PR3 and anti-MPO antibodies are not present in sera of patients with pulmonary tuberculosis
Lima I, Oliveira R, Cabral M, Atta A, Marchi S, Reis E, Reis M, Barbosa L, Santiago M. Anti-PR3 and anti-MPO antibodies are not present in sera of patients with pulmonary tuberculosis. Rheumatology International 2014, 34: 1231-1234. PMID: 24719228, DOI: 10.1007/s00296-014-3009-z.Peer-Reviewed Original ResearchConceptsAnti-neutrophil cytoplasmic antibodiesAnti-PR3 antibodiesIndirect immunofluorescencePresence of ANCAPrevalence of ANCAInfectious diseasesComponents of neutrophilsGroup of patientsAnti-MPO antibodiesSera of patientsChest X-rayAnti-PR3Cytoplasmic antibodiesVasculitic syndromesTB patientsPulmonary tuberculosisAutoimmune disordersPresent studyClinical similaritiesSuch antibodiesPatientsELISA kitTuberculosisAntibodiesAutoantibodies
2013
Antibodies to citrullinated peptides in tuberculosis
Lima I, Oliveira R, Atta A, Marchi S, Barbosa L, Reis E, Reis M, Santiago M. Antibodies to citrullinated peptides in tuberculosis. Clinical Rheumatology 2013, 32: 685-687. PMID: 23344687, DOI: 10.1007/s10067-013-2173-y.Peer-Reviewed Original ResearchConceptsAnti-citrullinated peptide antibodiesAnti-MCV antibodiesRheumatoid arthritisHealthy controlsRheumatoid factor positivityRA patientsSymmetric polyarthritisTB patientsPulmonary tuberculosisBone erosionCCP antibodyAutoimmune diseasesHigh incidencePeptide antibodiesPatientsControl groupHigh specificityTuberculosisInfectious diseasesAntibodiesPositivityDiseaseSpecificityMethodological factorsPolyarthritis
2009
Lipoprotein Cholesterol and Triglyceride in Children with Steady-State Sickle Cell Disease.
Seixas M, Rocha L, Carvalho M, Menezes J, Lyra I, Nascimento V, Couto R, Atta A, Reis M, Goncalves M. Lipoprotein Cholesterol and Triglyceride in Children with Steady-State Sickle Cell Disease. Blood 2009, 114: 1547. DOI: 10.1182/blood.v114.22.1547.1547.Peer-Reviewed Original ResearchHigh-density lipoprotein cholesterolLipoprotein cholesterolSickle cell disease pathogenesisPatients' medical recordsSickle cell diseasePro-fibrinolytic activityTotal cholesterolSignificant positive associationProspective studyMedical recordsSteady state childrenCell diseaseClinical dataHealthy subjectsDisease pathogenesisHematological analysisCholesterolCell counterPositive associationNegative associationElectronic cell counterAssociationPatientsPathogenesisMonocytesRisk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil.
Machado A, Finkmoore B, Emodi K, Takenami I, Barbosa T, Tavares M, Reis M, Arruda S, Riley L. Risk factors for failure to complete a course of latent tuberculosis infection treatment in Salvador, Brazil. The International Journal Of Tuberculosis And Lung Disease 2009, 13: 719-25. PMID: 19460247.Peer-Reviewed Original ResearchConceptsHousehold contactsLatent tuberculosis infectionLTBI treatmentLatent tuberculosis infection treatmentTB-endemic countriesRisks of treatmentHigh-risk populationPulmonary TBMedication intoleranceTuberculosis infectionTuberculosis controlRisk factorsHigh riskSide effectsInfection treatmentHospitalVisitsMonthsTreatmentFollowINHRiskTBRegimenPatientsAnalysis of discordance between the tuberculin skin test and the interferon-gamma release assay.
Machado A, Emodi K, Takenami I, Finkmoore B, Barbosa T, Carvalho J, Cavalcanti L, Santos G, Tavares M, Mota M, Barreto F, Reis M, Arruda S, Riley L. Analysis of discordance between the tuberculin skin test and the interferon-gamma release assay. The International Journal Of Tuberculosis And Lung Disease 2009, 13: 446-53. PMID: 19335949.Peer-Reviewed Original ResearchConceptsTuberculin skin testInterferon-gamma releaseHousehold contactsSkin testTST resultsLatent TB infectionPositive TST resultsPulmonary tuberculosis patientsChest X-rayAnalysis of discordancePTB patientsTB infectionTuberculosis patientsLung scarsIndex caseTest groupTest agreementPatientsIGRAPositive resultsGroupDiscordanceInfectionRelease
2008
Distribution of Hepatitis C virus (HCV) genotypes in seropositive patients in the state of Alagoas, Brazil
Gonzaga R, Rodart I, Reis M, Neto C, Silva D. Distribution of Hepatitis C virus (HCV) genotypes in seropositive patients in the state of Alagoas, Brazil. Brazilian Journal Of Microbiology 2008, 39: 644-647. PMID: 24031281, PMCID: PMC3768450, DOI: 10.1590/s1517-83822008000400008.Peer-Reviewed Original ResearchAnti-HCV seropositive patientsHepatitis C virus genotypesC virus genotypesSeropositive patientsGenotype 1Genotype 2Nested-reverse transcription-polymerase chain reactionVirus genotypesDetectable HCV RNATranscription-polymerase chain reactionRestriction fragment length polymorphismGenotype-specific primersHCV RNAGenotype 3Subtype 1bSubtype 1aPatientsSerum samplesChain reactionSignificant differencesFragment length polymorphismState of AlagoasLength polymorphismCoinfectionPrevalenceMethylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil
Barbosa C, Souza C, de Moura Neto J, da Glória Bomfim Arruda M, Barreto J, Reis M, Goncalves M. Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil. Genetics And Molecular Biology 2008, 31: 29-32. DOI: 10.1590/s1415-47572008000100005.Peer-Reviewed Original ResearchChronic myeloid leukemiaC677TAML-M3Development of CMLAcute lymphoid leukemiaMyeloid leukemia patientsMethylenetetrahydrofolate reductase (MTHFR) polymorphismsRestriction fragment length polymorphism methodFragment length polymorphism methodMTHFR C677TLength polymorphism methodSubtype M3Polymerase chain reactionHealthy controlsLeukemia patientsMyeloid leukemiaLymphoid leukemiaMTHFR polymorphismsMutant allele frequencyPolymorphism methodChain reactionPolymorphism frequenciesPatientsA1298CLeukemiaPolymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients
Souza C, Barbosa C, de Moura Neto J, Barreto J, Reis M, Gonçalves M. Polymorphisms in the glutathione S-transferase theta and mu genes and susceptibility to myeloid leukemia in Brazilian patients. Genetics And Molecular Biology 2008, 31: 39-41. DOI: 10.1590/s1415-47572008000100008.Peer-Reviewed Original ResearchChronic myeloid leukemiaAcute promyelocytic leukemiaRisk factorsMyeloid leukemiaTypes of leukemiaGlutathione S-transferase thetaGSTT1null genotypeAPL patientsGSTM1 polymorphismHealthy controlsBrazilian patientsPromyelocytic leukemiaNull genotypeControl groupGene polymorphismsGSTT1 genesLeukemiaPatientsMultiplex PCRPolymorphismDifferent populationsAssociation studiesGroup
2007
COMPARISON OF WHOLE BLOOD INTERFERON-GAMMA ASSAY WITH TUBERCULIN SKIN TESTING IN HOUSEHOLD CONTACTS OF PULMONARY TUBERCULOSIS PATIENTS IN SALVADOR, BRAZIL
Machado A, Szabo K, Barbosa T, Arruda S, Reis M, Riley L, Takenami I. COMPARISON OF WHOLE BLOOD INTERFERON-GAMMA ASSAY WITH TUBERCULIN SKIN TESTING IN HOUSEHOLD CONTACTS OF PULMONARY TUBERCULOSIS PATIENTS IN SALVADOR, BRAZIL. CHEST Journal 2007, 132: 433a-1-433a-2. DOI: 10.1378/chest.132.4_meetingabstracts.433a.Peer-Reviewed Original ResearchDetection of antinucleosome antibodies in systemic lupus erythematosus
Lima I, Barbosa L, Lopes M, Reis E, Reis M, Colossi K, Abreu M, Ferreira C, Santiago M. Detection of antinucleosome antibodies in systemic lupus erythematosus. Advances In Rheumatology 2007, 47: 160-164. DOI: 10.1590/s0482-50042007000300004.Peer-Reviewed Original ResearchDiagnosis of SLESystemic lupus erythematosusSystemic sclerosisDisease activitySLEDAI scoreLupus erythematosusAntinucleosome antibodiesSLE samplesDisease activity indexCross-sectional studyAnti-DNA antibodiesMean age 35Lack of associationMyositis patientsRheumatology criteriaRheumatologic practiceSLE patientsAge 35American CollegeActivity indexPatientsDiagnosisAntibodiesDiagnostic performanceELISA system